South San Francisco, CA Commercial Real Estate for Lease and Sale

Explore 85 listings of South San Francisco commercial real estate for lease and for sale to find the best space for your business.

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Edgewater Business Park

270 Littlefield Ave, The East Side, S San Francisco, CA
For Lease

$60.00/SF/YR
Property

Unassigned

15,500 SF
Availability

1 Space

15,500 SF
Year Built

1987
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San Francisco, CA Warehouse for Rent - #1597 | 500 - 50,000 sq ft

274 Wattis Way, San Bruno Canal, South San Francisco, CA
For Lease

$1.75/SF/MO
Property

Industrial

50,000 SF
Availability

1 Space

50,000 SF
Year Built

1958
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Genesis North Tower

2 Tower Place, Paradise Valley, S San Francisco, CA
For Lease

$51.00 - $84.00/SF/YR
Property

Unassigned

374,433 SF
Availability

4 Spaces

66,993 SF
Year Built

2018
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272 South Maple Avenue

272 South Maple Avenue, Downtown South San Francisco, South San Francisco, CA
For Lease

$1.45/SF/MO
Property

Industrial

32,952 SF
Availability

1 Space

28,271 SF
Year Built

1962
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390 Swift Avenue

390 Swift Avenue, The East Side, South San Francisco, CA
For Lease

$2.25/SF/MO
Property

Industrial

107,928 SF
Availability

1 Space

7,200 SF
Year Built

1980
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1098 San Mateo Avenue

1098 San Mateo Avenue, Lindenville, South San Francisco, CA
For Lease

$1.50/SF/MO
Property

Industrial

32,642 SF
Availability

1 Space

6,644 SF
Year Built

1975
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341-365 Swift Avenue

341 Swift Avenue, The East Side, South San Francisco, CA
For Lease

$2.15 - $2.20/SF/MO
Property

Industrial

67,058 SF
Availability

2 Spaces

16,678 SF
Year Built

1978
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WAREHOUSE SPACE FOR SUBLEASE

233 E Harris Ave, The East Side, South San Francisco, CA
For Lease

$1.55/SF/MO
Property

Industrial
Availability

1 Space

60,000 SF
Year Built

1979
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The Nexus on Grand

233 East Grand Avenue, The East Side, South San Francisco, CA
For Lease

Contact for pricing
Property

Office

148,500 SF
Availability

2 Spaces

53,682 SF
Year Built

2023
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617 Airport Blvd

617 Airport Blvd, Downtown South San Francisco, South San Francisco, CA
For Sale

Inquire for Pricing
Property

Industrial

14,889 SF
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Produce Avenue Business Park

100 Produce Avenue, Lindenville, South San Francisco, CA
For Lease

$0.80 - $1.50/SF/MO
Property

Office

41,448 SF
Availability

2 Spaces

3,917 SF
Year Built

1986
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WAREHOUSE SPACE FOR LEASE

434 N Canal St, Lindenville, South San Francisco, CA
For Lease

$1.85 - $5.00/SF/MO
Property

Industrial
Availability

2 Spaces

6,060 SF
Year Built

1990
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Britannia Modular Labs I

285 East Grand Avenue, The East Side, South San Francisco, CA
For Lease

Contact for pricing
Property

Office

61,770 SF
Availability

2 Spaces

62,000 SF
Year Built

2006
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The Gateway North Campus - 901 Gateway Blvd

901 Gateway Blvd, Gateway, South San Francisco, CA
For Lease

$4.50/SF/MO
Property

Office

110,428 SF
Availability

3 Spaces

78,070 SF
Year Built

2000
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The Cove at Oyster Point VII

131 Oyster Point Blvd, Oyster Point, South San Francisco, CA
For Lease

Contact for pricing
Property

Office

175,830 SF
Availability

2 Spaces

49,093 SF
Year Built

2019
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Britannia Oyster Point I - C

1140 Veterans Blvd, Oyster Point, South San Francisco, CA
For Lease

Contact for pricing
Property

Office

67,000 SF
Availability

3 Spaces

69,058 SF
Year Built

2003
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Gateway Commons - 601 Gateway

601 Gateway Blvd, Gateway, South San Francisco, CA
For Lease

$4.25/SF/MO
Property

Office

215,832 SF
Availability

9 Spaces

72,632 SF
Year Built

1984
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WAREHOUSE BUILDING FOR SALE

432 N Canal St, Lindenville, South San Francisco, CA
For Sale

$1,300,000
Property

Industrial

53,529 SF
Year Built

1991
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6000 Shoreline Court

6000 Shoreline Court, Paradise Valley, South San Francisco, CA
For Lease

Contact for pricing
Property

Office

139,372 SF
Availability

5 Spaces

43,017 SF
Year Built

2001
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ReadySpaces South San Francisco Spruce

245 South Spruce Avenue, Lindenville, South San Francisco, CA
For Lease

Contact for pricing
Property

Industrial

559,605 SF
Availability

2 Spaces

7,000 SF
Year Built

1957
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The Cove at Oyster Point III

151 Oyster Point Blvd, Oyster Point, South San Francisco, CA
For Lease

Contact for pricing
Property

Office

153,047 SF
Availability

1 Space

14,432 SF
Year Built

2016
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The Cove at Oyster Point IV

171 Oyster Point Blvd, Oyster Point, South San Francisco, CA
For Lease

Contact for pricing
Property

Office

140,053 SF
Availability

1 Space

4,968 SF
Year Built

2016
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Edgewater Science Park

260 Littlefield Avenue, The East Side, South San Francisco, CA
For Lease

Contact for pricing
Property

Office

169,359 SF
Availability

1 Space

6,139 SF
Year Built

1988
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Gateway Crossing - 201 & 225 Gateway Blvd

225 Gateway Blvd, Gateway, South San Francisco, CA
For Lease

Contact for pricing
Property

Office

106,076 SF
Availability

1 Space

15,559 SF
Year Built

1998
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Britannia Oyster Point II - Building B

331 Oyster Point Blvd, Oyster Point, South San Francisco, CA
For Lease

Contact for pricing
Property

Office

128,751 SF
Availability

4 Spaces

134,237 SF
Year Built

2008
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7000 Shoreline Court

7000 Shoreline Court, Paradise Valley, South San Francisco, CA
For Lease

Contact for pricing
Property

Office

136,395 SF
Availability

2 Spaces

9,780 SF
Year Built

2003
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Frequently Asked Questions

Commercial real estate is a broad category that includes a high variety of space types designed to meet the needs of various industries of the local economy and their specialized subsectors, as presented in our real estate 101 guide to types of commercial real estate. However, there are three main categories that you are most likely to come across: office, retail, and industrial space.

Modern office space is typically organized over large floor plates bound by high ceilings and large windows for an abundance of natural light and is located in transit-oriented developments with good access to multiple modes of transportation, so as to facilitate employee commute. The South San Francisco commercial real estate market incorporates 4,382,312 square feet of office space across 28 buildings.

Office buildings can also accommodate coworking spaces, which are shared office options that typically cater to the needs of small, startup businesses that require flexible workspaces, a concentration of amenities, and services that can be accessed on an occasional or short-term basis.
Retail space includes shopping malls, department stores, street retail, or specialty stores dedicated to a narrow range of products. Such properties are typically located in high foot-traffic and/or car traffic areas, to facilitate customer access. The South San Francisco commercial real estate market includes 69,614 square feet of retail space in a variety of settings.
Industrial property most often serves businesses operating in manufacturing or logistics and generally consists of large open spaces located within good access to roads, railways, freight airports or regional water ports. Industrial space listings can include warehouses, manufacturing plants, distribution centers, flexible industrial space, or even data center facilities. Across the South San Francisco market, there is a total of 2,570,288 square feet of industrial property.

The listing inventory in South San Francisco incorporates commercial real estate for lease and for sale of almost all property types and subtypes. However, you’ll find some categories offer more rental or investment opportunities than others.

The largest share of commercial real estate space for lease in South San Francisco is represented by Office space, which accounts for 1,707,921 square feet of available listings. Industrial space available in South San Francisco adds up to 840,243 square feet.

Meanwhile, most of the listings of commercial property for sale in South San Francisco are in the Industrial category.

The price of renting or buying commercial real estate is influenced by a variety of factors, including: the property type (for example, office space is priced higher than other property types in most locations); the condition and asset class rating (property rated class A or above will typically command a higher price than lower grade classifications); the quality or the development potential of the property location; whether or not there is high demand for the type of commercial asset in question; and what the state of supply is relative to demand.

The average rent for commercial real estate space listed for lease in South San Francisco is $28.04 per square foot. However, this value does not offer enough perspective on its own, as you will find significant variation in prices across property types, property classes, and location, as well as other impacting factors. For instance, rent per square foot of office space in South San Francisco can vary greatly depending on the rating of the property from Class A to Class C, as well as across the city depending on the location of the asset. What’s more, each commercial property type makes its own rent market: while the average rent for office space rested at $47.91 per square foot, industrial space in South San Francisco saw average rents of $22.48 per square foot.

Whether you are looking for commercial real estate for lease or commercial property for sale, the best choice of location depends on the factors that are most relevant to your business strategy. A good thing to look for at the start, however, is the areas of the city that have the highest concentration of your preferred type of property, as these areas are generally well connected to the amenities and points of interest that are most relevant to each property type.

As such, there are several areas that you could consider to be the best location for commercial real estate in South San Francisco, depending on the property type you are interested in. The highest concentration of commercial space listings of any kind in South San Francisco is in the The East Side neighborhood. But if we look at each commercial property type, we find that for office space, the best location is the The East Side area.

Meanwhile, retail space opportunities are most abundant in the San Bruno Canal submarket. Alternatively, if you are looking for warehouse or other industrial space, consider looking at listings in The East Side.

Select your preferred property type from the search filters menu at the top of the search page and then navigate the interactive map for a better view of commercial real estate availability in the locations most suited to your needs.

Regardless of whether buying or leasing commercial space is a new experience for you, there are significant benefits to working with a commercial real estate broker. In addition to saving you time and money, an experienced broker will contribute specialist knowledge of the local market, the property type you need representation for, and will handle negotiations on your behalf in your best interest.

To start, it is important for you to have a good understanding of what kind of broker you need. For instance, there are differences between a tenant broker and a listing broker. Also important at the start is to have a clear idea of what kind of space (or tenant) you are looking for and what (if any) particular needs and requirements you might have. And, while it is good to get a referral, you should interview several brokers to better gauge who you feel would best represent your interests.

CommercialCafe hosts listings from some of the most trusted commercial real estate brokerages in the country. Use the contact form available on each listing page or the contact details for the property representatives to reach out and start your search!

The profitability of a commercial real estate investment depends on a multitude of factors working together. These factors include the quality of the asset itself — which itself includes aspects such as location, property class, amenities, and the quality of the property management — to the local market conditions, the state of the local economy, the demand for that particular type of commercial property, and of course the costs of owning and maintaining it relative to what leasing rate or sale price you get from the property. Asking rents in the city went as high as $51 per square foot. In particular, the property type commanding the highest lease rates in South San Francisco was Office space.

Conversely, the highest sale price last year was $170,000,000 that is located at 7000 Shoreline Court.

The average size of a commercial property in South San Francisco depends greatly on the property type and the location — geographical possibilities and zoning allowances have significant influence on how big developers can build. While there are outliers that break height or volume records in the city, we can look at some average sizes by property use:

In South San Francisco, the average size of an office property is 182,597 square feet.
Retail properties here incorporate an average of 34,807 square feet.
Industrial space in South San Francisco is in buildings that are, on average 82,913 square feet in size.

South San Francisco, CA Currently Available Listings

Commercial Space for Lease Breakdown

Commercial real estate listings for rent in South San Francisco currently add up to 2,943,304 square feet. The market offers 31 active office listing(s), which amount to 1,740,389 square feet and account for 43% of commercial spaces on the market. Local retail availability includes 77,081 square feet across 4 retail space(s). Industrial space for rent opportunities in South San Francisco amount to 747,161 square feet across a total of 32 warehouse and other industrial listing(s).

Property Type	Count of Listings	Total SF
Office	31	1,740,389
Retail	4	77,081
Industrial	32	747,161
Other	4	378,673

Commercial Space for Sale Breakdown

What’s more, if you are interested in making an investment in the local market, you can also find commercial real estate for sale in South San Francisco, CA. Currently, there is 340,705 square feet of commercial property for sale here , which includes 10 listing(s) of industrial real estate property for sale .

Property Type	Count of Listings	Total SF
Industrial	10	318,730
Other	1	21,975

South San Francisco, CA Commercial Real Estate for Lease and Sale

Edgewater Business Park

San Francisco, CA Warehouse for Rent - #1597 | 500 - 50,000 sq ft

Genesis North Tower

272 South Maple Avenue

390 Swift Avenue

1098 San Mateo Avenue

341-365 Swift Avenue

WAREHOUSE SPACE FOR SUBLEASE

The Nexus on Grand

617 Airport Blvd

Produce Avenue Business Park

WAREHOUSE SPACE FOR LEASE

Britannia Modular Labs I

The Gateway North Campus - 901 Gateway Blvd

The Cove at Oyster Point VII

Britannia Oyster Point I - C

Gateway Commons - 601 Gateway

WAREHOUSE BUILDING FOR SALE

6000 Shoreline Court

ReadySpaces South San Francisco Spruce

The Cove at Oyster Point III

The Cove at Oyster Point IV

Edgewater Science Park

Gateway Crossing - 201 & 225 Gateway Blvd

Britannia Oyster Point II - Building B

7000 Shoreline Court

Frequently Asked Questions

South San Francisco, CA Currently Available Listings

Commercial Space for Lease Breakdown

Commercial Space for Sale Breakdown

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South San Francisco, CA Commercial Real Estate for Lease and Sale

Frequently Asked Questions

What are the different types of commercial real estate?

What types of commercial real estate are available in South San Francisco, CA?

What factors affect the price of commercial real estate in South San Francisco, CA?

What is the average rent for commercial space in South San Francisco, CA?

What are the best areas for commercial real estate in South San Francisco, CA?

How do I find a good commercial real estate broker?

What is the most profitable commercial real estate?

What is the average size of a commercial property in South San Francisco, CA?

South San Francisco, CA Currently Available Listings

Commercial Space for Lease Breakdown

Commercial Space for Sale Breakdown

Other Popular Searches

Popular Coworking Searches

Popular Office Searches

Popular Retail Searches

Popular Industrial Searches

About us