South San Francisco, CA Commercial Real Estate for Lease - 73 Listings

The Cove at Oyster Point III

151 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Property

Office

153,047 SF
Availability

1 Space

14,432 SF
Year Built

2016
For Lease Contact for pricing
View Details (opens in new window)
Edgewater Science Park

260 Littlefield Avenue, The East Side, South San Francisco, CA
Property

Office

169,359 SF
Availability

1 Space

6,139 SF
Year Built

1988
For Lease Contact for pricing
View Details (opens in new window)
Britannia Modular Labs IV

100 Kimball Way, The East Side, South San Francisco, CA
Property

Office

104,930 SF
Availability

2 Spaces

25,991 SF
Year Built

1968
For Lease Contact for pricing
View Details (opens in new window)
570-586 Eccles Ave

570-586 Eccles Ave, The East Side, S San Francisco, CA
Property

Industrial

375,000 SF
Availability

2 Spaces

137,730 SF
Year Built

1965
For Lease Contact for pricing
View Details (opens in new window)
407 Cabot Rd

407 Cabot Rd, The East Side, South San Francisco, CA
Property

Flex Space

919 SF
Availability Contact for availability
Year Built

1965
For Lease Contact for pricing
View Details (opens in new window)
Genesis North Tower

2 Tower Place, Paradise Valley, S San Francisco, CA
Property

Unassigned

374,433 SF
Availability

4 Spaces

66,993 SF
Year Built

2018
For Lease

$51.00 - $84.00/SF/YR
View Details (opens in new window)
250 Hillside Blvd

250 Hillside Blvd, Paradise Valley, South San Francisco, CA
Property

Industrial

28,726 SF
Availability

1 Space

29,800 SF
Year Built

1951
For Lease

$1.75/SF/MO
View Details (opens in new window)
Britannia Modular Labs I

285 East Grand Avenue, The East Side, South San Francisco, CA
Property

Office

61,770 SF
Availability

2 Spaces

62,000 SF
Year Built

2006
For Lease Contact for pricing
View Details (opens in new window)
240-242 Lawrence

240-242 Lawrence Ave, The East Side, S San Francisco, CA
Property

Industrial

40,000 SF
Availability

1 Space

17,233 SF
For Lease

$27.00/SF/YR
View Details (opens in new window)
PS BUSINESS PARK

90 S Spruce Ave, Orange Park, South San Francisco, CA
Property

Office
Availability

4 Spaces

5,542 SF
Year Built

1986
For Lease

$1.75 - $1.95/SF/MO
View Details (opens in new window)
Upgrade your lease management practices

Simplify your accounting operations and seamlessly track, manage and collaborate on your lease portfolio from anywhere.
Learn more
499 Forbes Blvd

499 Forbes Blvd, The East Side, S San Francisco, CA
Property

Unassigned

144,249 SF
Availability

6 Spaces

144,249 SF
Year Built

2022
For Lease Contact for pricing
View Details (opens in new window)
Victory Business Center

441 Victory Avenue, Lindenville, South San Francisco, CA
Property

Industrial

32,954 SF
Availability

2 Spaces

6,766 SF
Year Built

1990
For Lease

$1.70 - $1.95/SF/MO
View Details (opens in new window)
Britannia Pointe Grand

250 East Grand Avenue, The East Side, South San Francisco, CA
Property

Office

630,500 SF
Availability

6 Spaces

146,211 SF
Year Built

1989
For Lease Contact for pricing
View Details (opens in new window)
Britannia Oyster Point II - Building B

331 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Property

Office

128,751 SF
Availability

4 Spaces

134,237 SF
Year Built

2008
For Lease Contact for pricing
View Details (opens in new window)
201 Haskins Way

201 Haskins Way, The East Side, South San Francisco, CA
Property

Office

311,368 SF
Availability

1 Space

10,709 SF
Year Built

2021
For Lease Contact for pricing
View Details (opens in new window)
395 Oyster Point Blvd

395 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Property

Office

234,480 SF
Availability

1 Space

25,000 SF
Year Built

1987
For Lease Contact for pricing
View Details (opens in new window)
The Cove at Oyster Point VII

131 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Property

Office

175,830 SF
Availability

2 Spaces

49,093 SF
Year Built

2019
For Lease Contact for pricing
View Details (opens in new window)
343 El Camino Real

343 El Camino Real, Avalon Park, South San Francisco, CA
Property

Mixed Use

3,765 SF
Availability

1 Space

605 SF
Year Built

1966
For Lease

$2.97/SF/YR
View Details (opens in new window)
The Cove at Oyster Point IV

171 Oyster Point Blvd, Oyster Point, South San Francisco, CA
Property

Office

140,053 SF
Availability

1 Space

4,968 SF
Year Built

2016
For Lease Contact for pricing
View Details (opens in new window)
San Francisco, CA Warehouse for Rent - #1597 | 500 - 50,000 sq ft

274 Wattis Way, San Bruno Canal, South San Francisco, CA
Property

Industrial

50,000 SF
Availability

1 Space

50,000 SF
Year Built

1958
For Lease

$2.50/SF/MO
View Details (opens in new window)
The Nexus on Grand

233 East Grand Avenue, The East Side, South San Francisco, CA
Property

Office

148,500 SF
Availability

2 Spaces

53,682 SF
Year Built

2023
For Lease Contact for pricing
View Details (opens in new window)
499 Forbes Blvd

499 Forbes Blvd, The East Side, South San Francisco, CA
Property

Flex Space

144,209 SF
Availability Contact for availability
Year Built

2022
For Lease Contact for pricing
View Details (opens in new window)
300-332 Littlefield Avenue

310 Littlefield Avenue, The East Side, South San Francisco, CA
Property

Industrial

64,425 SF
Availability

1 Space

11,760 SF
Year Built

1975
For Lease

$1.15/SF/MO
View Details (opens in new window)
Gateway Commons - 601 Gateway

601 Gateway Blvd, Gateway, South San Francisco, CA
Property

Office

215,832 SF
Availability

9 Spaces

72,632 SF
Year Built

1984
For Lease

$4.25/SF/MO
View Details (opens in new window)
5000 Shoreline Court

5000 Shoreline Court, Paradise Valley, South San Francisco, CA
Property

Office

138,399 SF
Availability

5 Spaces

84,537 SF
Year Built

2000
For Lease Contact for pricing
View Details (opens in new window)
The Gateway North Campus - 901 Gateway Blvd

901 Gateway Blvd, Gateway, South San Francisco, CA
Property

Office

110,428 SF
Availability

3 Spaces

78,070 SF
Year Built

2000
For Lease

$4.50/SF/MO
View Details (opens in new window)

Frequently Asked Questions

Commercial real estate is a broad category that includes a high variety of space types designed to meet the needs of various industries of the local economy and their specialized subsectors, as presented in our real estate 101 guide to types of commercial real estate. However, there are three main categories that you are most likely to come across: office, retail, and industrial space.

Modern office space is typically organized over large floor plates bound by high ceilings and large windows for an abundance of natural light and is located in transit-oriented developments with good access to multiple modes of transportation, so as to facilitate employee commute. The South San Francisco commercial real estate market incorporates 5,189,630 square feet of office space across 33 buildings.

Office buildings can also accommodate coworking spaces, which are shared office options that typically cater to the needs of small, startup businesses that require flexible workspaces, a concentration of amenities, and services that can be accessed on an occasional or short-term basis.
Retail space includes shopping malls, department stores, street retail, or specialty stores dedicated to a narrow range of products. Such properties are typically located in high foot-traffic and/or car traffic areas, to facilitate customer access. The South San Francisco commercial real estate market includes 75,112 square feet of retail space in a variety of settings.
Industrial property most often serves businesses operating in manufacturing or logistics and generally consists of large open spaces located within good access to roads, railways, freight airports or regional water ports. Industrial space listings can include warehouses, manufacturing plants, distribution centers, flexible industrial space, or even data center facilities. Across the South San Francisco market, there is a total of 2,042,518 square feet of industrial property.

The listing inventory in South San Francisco incorporates commercial real estate for lease and for sale of almost all property types and subtypes. However, you’ll find some categories offer more rental or investment opportunities than others.

The largest share of commercial real estate space for lease in South San Francisco is represented by Office space, which accounts for 1,797,704 square feet of available listings. Industrial space available in South San Francisco adds up to 735,415 square feet.

Meanwhile, most of the listings of commercial property for sale in South San Francisco are in the Industrial category.

The price of renting or buying commercial real estate is influenced by a variety of factors, including: the property type (for example, office space is priced higher than other property types in most locations); the condition and asset class rating (property rated class A or above will typically command a higher price than lower grade classifications); the quality or the development potential of the property location; whether or not there is high demand for the type of commercial asset in question; and what the state of supply is relative to demand.

The average rent for commercial real estate space listed for lease in South San Francisco is $32.85 per square foot. However, this value does not offer enough perspective on its own, as you will find significant variation in prices across property types, property classes, and location, as well as other impacting factors. For instance, rent per square foot of office space in South San Francisco can vary greatly depending on the rating of the property from Class A to Class C, as well as across the city depending on the location of the asset. What’s more, each commercial property type makes its own rent market: while the average rent for office space rested at $48.02 per square foot, industrial space in South San Francisco saw average rents of $22.45 per square foot.

Whether you are looking for commercial real estate for lease or commercial property for sale, the best choice of location depends on the factors that are most relevant to your business strategy. A good thing to look for at the start, however, is the areas of the city that have the highest concentration of your preferred type of property, as these areas are generally well connected to the amenities and points of interest that are most relevant to each property type.

As such, there are several areas that you could consider to be the best location for commercial real estate in South San Francisco, depending on the property type you are interested in. The highest concentration of commercial space listings of any kind in South San Francisco is in the The East Side neighborhood. But if we look at each commercial property type, we find that for office space, the best location is the The East Side area.

Meanwhile, retail space opportunities are most abundant in the San Bruno Canal submarket. Alternatively, if you are looking for warehouse or other industrial space, consider looking at listings in The East Side.

Select your preferred property type from the search filters menu at the top of the search page and then navigate the interactive map for a better view of commercial real estate availability in the locations most suited to your needs.

Regardless of whether buying or leasing commercial space is a new experience for you, there are significant benefits to working with a commercial real estate broker. In addition to saving you time and money, an experienced broker will contribute specialist knowledge of the local market, the property type you need representation for, and will handle negotiations on your behalf in your best interest.

To start, it is important for you to have a good understanding of what kind of broker you need. For instance, there are differences between a tenant broker and a listing broker. Also important at the start is to have a clear idea of what kind of space (or tenant) you are looking for and what (if any) particular needs and requirements you might have. And, while it is good to get a referral, you should interview several brokers to better gauge who you feel would best represent your interests.

CommercialCafe hosts listings from some of the most trusted commercial real estate brokerages in the country. Use the contact form available on each listing page or the contact details for the property representatives to reach out and start your search!

The profitability of a commercial real estate investment depends on a multitude of factors working together. These factors include the quality of the asset itself — which itself includes aspects such as location, property class, amenities, and the quality of the property management — to the local market conditions, the state of the local economy, the demand for that particular type of commercial property, and of course the costs of owning and maintaining it relative to what leasing rate or sale price you get from the property. Asking rents in the city went as high as $60 per square foot. In particular, the property type commanding the highest lease rates in South San Francisco was Office space.

The average size of a commercial property in South San Francisco depends greatly on the property type and the location — geographical possibilities and zoning allowances have significant influence on how big developers can build. While there are outliers that break height or volume records in the city, we can look at some average sizes by property use:

In South San Francisco, the average size of an office property is 192,209 square feet.
Retail properties here incorporate an average of 25,038 square feet.
Industrial space in South San Francisco is in buildings that are, on average 65,888 square feet in size.

South San Francisco, CA Currently Available Listings

Commercial Space for Lease Breakdown

Commercial real estate listings for rent in South San Francisco currently add up to 2,987,873 square feet. The market offers 33 active office listing(s), which amount to 1,797,704 square feet and account for 45% of commercial spaces on the market. Local retail availability includes 76,081 square feet across 4 retail space(s). Industrial space for rent opportunities in South San Francisco amount to 735,415 square feet across a total of 30 warehouse and other industrial listing(s).

Property Type	Count of Listings	Total SF
Office	33	1,797,704
Retail	4	76,081
Industrial	30	735,415
Other	5	378,673

Commercial Space for Sale Breakdown

What’s more, if you are interested in making an investment in the local market, you can also find commercial real estate for sale in South San Francisco, CA. Currently, there is 346,203 square feet of commercial property for sale here , which includes , 1 retail investment opportunity listing(s) , and 10 listing(s) of industrial real estate property for sale .

Property Type	Count of Listings	Total SF
Retail	1	5,498
Industrial	10	318,730
Other	1	21,975

South San Francisco, CA Commercial Real Estate for Lease - 73 Listings

The Cove at Oyster Point III

Edgewater Science Park

Britannia Modular Labs IV

570-586 Eccles Ave

407 Cabot Rd

Genesis North Tower

250 Hillside Blvd

Britannia Modular Labs I

240-242 Lawrence

PS BUSINESS PARK

499 Forbes Blvd

Victory Business Center

Britannia Pointe Grand

Britannia Oyster Point II - Building B

201 Haskins Way

395 Oyster Point Blvd

The Cove at Oyster Point VII

343 El Camino Real

The Cove at Oyster Point IV

San Francisco, CA Warehouse for Rent - #1597 | 500 - 50,000 sq ft

The Nexus on Grand

499 Forbes Blvd

300-332 Littlefield Avenue

Gateway Commons - 601 Gateway

5000 Shoreline Court

The Gateway North Campus - 901 Gateway Blvd

Frequently Asked Questions

South San Francisco, CA Currently Available Listings

Commercial Space for Lease Breakdown

Commercial Space for Sale Breakdown

Other Popular Searches

Popular Coworking Searches

Popular Office Searches

Popular Retail Searches

Popular Industrial Searches

About us

About Us

Our Tools

South San Francisco, CA Commercial Real Estate for Lease - 73 Listings

Frequently Asked Questions

What are the different types of commercial real estate?

What types of commercial real estate are available in South San Francisco, CA?

What factors affect the price of commercial real estate in South San Francisco, CA?

What is the average rent for commercial space in South San Francisco, CA?

What are the best areas for commercial real estate in South San Francisco, CA?

How do I find a good commercial real estate broker?

What is the most profitable commercial real estate?

What is the average size of a commercial property in South San Francisco, CA?

South San Francisco, CA Currently Available Listings

Commercial Space for Lease Breakdown

Commercial Space for Sale Breakdown

Other Popular Searches

Popular Coworking Searches

Popular Office Searches

Popular Retail Searches

Popular Industrial Searches

About us