4321 Medical Park Dr

4321 Medical Park Dr, Durham, NC 27704

  • For Lease $23.00/SF/YR
  • Property Type Office - General Office
  • Property Size 79,440 SF
  • Lot Size 8.17 Acre
  • Building Class A
  • Year Built 2001
  • Date Updated Aug 19, 2025
4321 Medical Park Drive is a Class A office building located in a large medical hub, Independence Park, across from Duke Regional Hospital in North Durham. The thriving park contains various medical and health-related occupants as well as retail and restaurants nearby. Downtown Durham and Duke University are only 4 and 5 miles away respectively.Class A office space for lease in North Durham available December 1, 2025. Ability to combine suites for up to 27,735 SF.
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Highlights

  • 79,202 SF two-story medical and office building
  • Ability to combine suites for up to 27,735 SF
  • Built in 2001 - attractive concrete, steel and glass construction
  • Dock loading in rear of building
  • Freight elevator and backup generator onsite
  • Gorgeous atrium with circular staircase
  • High ceilings and upgraded finishes
  • Lease rate: $23.00/SF full service
  • Plentiful parking onsite (4.8 per 1,000 SF)

Spaces Available

Contacts

broker
Brian Farmer

Lee & Associates

Location

Getting Around

  • Walk Score ®

    20/100 Car-Dependent

  • Transit Score ®

    30/100 Some Transit

  • Bike Score ®

    30/100 Somewhat Bikeable
Powered by Walk Score ®
  • City Durham, NC
  • Neighborhood Summer Meadow
  • Zip Code 27704
  • Market Raleigh Durham

Points of Interest

  • Durham

    3.63 miles

  • Shell

    0.71 miles

  • Sheetz

    0.76 miles

  • Bragtown Shell

    0.87 miles

  • Citgo

    0.88 miles

  • Kangaroo Express

    0.89 miles

  • Family Fare

    1.27 miles

  • Harris Teeter Fuel

    1.67 miles

  • Costco Gasoline

    1.86 miles

  • Town 'N' Country

    1.97 miles

  • EVgo

    9.53 miles

  • Saint Lukes Episcopal Church

    2.91 miles

  • Biddle Music Parking Lot

    3.00 miles

  • Branson Hall Parking

    3.01 miles

  • Brown Parking Lot

    3.03 miles

  • Bivins Parking Lot

    3.05 miles

  • Pegram Parking Lot

    3.08 miles

  • Wilson House/Red Zone

    3.12 miles

  • Epworth Parking Lot

    3.14 miles

  • Randolph Parking Lot

    3.18 miles

  • Gilbert-Addoms Lot

    3.22 miles

  • Red Roof Inn Durham Duke University Medical Center

    2.14 miles

  • Holiday Inn Express

    2.23 miles

  • Hampton Inn & Suites North I 85

    2.23 miles

  • Super 8 by Wyndham Durham/University Area NC

    2.28 miles

  • Carolina Duke Inn

    2.33 miles

  • Comfort Inn Medical Park

    2.68 miles

  • Courtyard

    2.80 miles

  • Duke Tower

    3.10 miles

  • Hilton Garden Inn Durham/University Medical Center

    3.37 miles

  • Residence Inn Durham McPherson/Duke University Medical Center Area

    3.41 miles

  • Chick-fil-A

    0.56 miles

  • Captain D's

    0.58 miles

  • Zaxby's

    0.58 miles

  • McDonald's

    0.61 miles

  • Freddy's

    0.63 miles

  • Chipotle

    0.63 miles

  • Panera Bread

    0.65 miles

  • Taqueria Los Amigos

    0.66 miles

  • Taco Bell

    0.70 miles

  • Bojangles'

    0.85 miles

  • Voyager Academy

    0.24 miles

  • Excelsior Classical Academy

    0.40 miles

  • City of Medicine School

    0.91 miles

  • Holt Elementary School

    0.93 miles

  • Northern High School

    0.95 miles

  • Braggtown School

    1.01 miles

  • Lakeview School

    1.17 miles

  • Wright School

    1.21 miles

  • Sandy Ridge Elementary School

    1.38 miles

  • Brogden Middle School

    1.93 miles

  • Sunshine Smiles

    1.32 miles

  • United For Christ Church Day Care Center

    4.14 miles

  • New Beginning II

    4.48 miles

  • Lakewood Avenue Children's School

    4.64 miles

Frequently Asked Questions

What is the price for renting office space at 4321 Medical Park Dr?

The price for office space here is $23.00/SF/YR.

What type of office space is available to lease at 4321 Medical Park Dr?

In total, there is 24,200 square feet of office space for lease here. Availability at this location includes 4 Office spaces.

Is 4321 Medical Park Dr suitable for a small business?

Yes, availabilities here may be suitable for small businesses with 2 office spaces under 5,000 square feet available. Space sizes here start at 3,800 square feet.

Does 4321 Medical Park Dr have parking?
Parking information for the property isn't currently listed. However, other nearby parking options include Saint Lukes Episcopal Church, located 2.91 miles away, and Biddle Music Parking Lot, which is 3 miles away.
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Contact Listing Broker
broker
Brian Farmer

Lee & Associates

  1. 1Main information
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