4100 N. Main Street

4100 N. Main Street, Columbia, SC 29203

Property Information

  • For Lease $20.00 - $22.00/SF/YR
  • Property Type Office - General Office
  • Property Size 18,937 SF
  • Lot Size 1.3 Acre
  • Building Class B
  • Year Built 1987
  • Year Renovated 2019
  • Date Updated Jun 30, 2026

Description

Located on North Main Street in North Columbia near the revitalized NOMA district. Easy access to downtown Columbia, I-26, I-277 and a few miles from I-20.Turnkey Medical Office Space Ranging from 1,226 SF up to 3,742 SF

Highlights

  • Located in Columbia's growing North Main (NOMA) corridor
  • Major renovations in 2019 included a new roof, building façade, and common area upgrades
  • Suite 101: ±2,484 SF available 8/1/26
  • Suite 200: ±1,226 SF with reception area, 3 exam rooms (with plumbing), 1 private office, and restroom
  • Suite 201: ±2,516 SF with large reception/waiting area, 6 exam rooms with plumbing, 2 private offices, IT and storage rooms, and restroom

3 Spaces Available

200

Space Type

Office

Lease Rate

$20.00/SF/YR

Total Space

1,226 SF

Divisible Space

1,226 - 1,226 SF

Available Date

Immediate

Lease Type

Full Service

Renewal Option

Yes

Sublease

No

Turnkey

Yes

201

Space Type

Office

Lease Rate

$20.00/SF/YR

Total Space

2,516 SF

Divisible Space

2,516 - 2,516 SF

Available Date

Immediate

Lease Type

Full Service

Renewal Option

Yes

Sublease

No

Turnkey

Yes

Suite 101

Space Type

Office

Lease Rate

$22.00/SF/YR

Total Space

2,484 SF

Divisible Space

2,484 - 2,484 SF

Available Date

Immediate

Lease Type

Full Service

Renewal Option

Yes

Sublease

No

Turnkey

Yes

Contacts

Location

Located at 4100 N. Main Street, Columbia, SC 29203, this property is part of the Seminary Ridge neighborhood and Columbia market.

Contact Listing Broker
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