Two Suites Available for Lease in Office/Medical Building | Columbia

4100 N Main St, Columbia, SC 29203

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Property Information

  • For Lease Contact for pricing
  • Property Type Office - General Office
  • Year Renovated 2019
  • Date Updated May 18, 2026

Description

Located at 4100 North Main Street, these two contiguous suites are available in a two-story freestanding office building. The building was recently renovated in 2019 and sits on a large ±1.3-acre lot, providing ample parking for tenants and clients. The property is situated in the North Main (NOMA) district of Downtown Columbia. The location offers convenient access to Downtown Columbia, Prisma Health Richland Hospital, Interstate 126 and Highway 277.

Available suites for lease:

Suite 200 | ±1,226 SF
Suite 201 | ±2,516 SF
Can be combined for a total contiguous area of ±3,742 SF

For more information, please download the flyer and contact the listing brokers, Tommy Johnson or Mary Winter Teaster.

Highlights

  • 2 miles to Bull Street District
  • 2 miles to Downtown Columbia and Prisma Health Richland Hospital
  • Generous onsite parking
  • Predominantly configured for clinical and medical uses but can also support traditional office use
  • Property managed by Colliers

1 Space Available

Space Available

Space Type

General Office

Lease Rate

Contact for pricing

Total Space

3,742 SF

Divisible Space

1,226 - 3,742 SF

Available Date

Immediate

Renewal Option

Yes

Sublease

No

Build Type

Full build out

Contacts

Thomas Johnson

Colliers

Mary Teaster

Colliers

Location

Located at 4100 N Main St, Columbia, SC 29203, this property is part of the Seminary Ridge neighborhood and Columbia market.

  • 63/100 Somewhat Walkable
  • 32/100 Some Transit
  • 37/100 Somewhat Bikeable
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