Sienna Medical Plaza | Medical Office Space Missouri City TX

Now leasing medical office space at Sienna Medical Plaza in Missouri City, TX—a high-demand submarket for healthcare-focused users. Schedule a tour today.

Sienna Medical Plaza is a newly delivered, two-story, 36,800 SF Class A medical office building strategically positioned along Highway 6 in the heart of the Sienna master-planned community in Missouri City, Texas. The property is purpose-built for healthcare and anchored by MD Anderson Cancer Center, which occupies the entire first floor, immediately establishing the building as a recognized medical destination within Fort Bend County.

The available opportunity consists of the full 18,400 SF second floor, offering a contiguous, efficient floor plate designed to accommodate specialty medical, imaging, infusion, oncology support, women’s health, surgical consult, therapy, and other referral-based healthcare providers. Elevator-served and fully sprinklered, the building provides institutional quality construction and professional lobby access, delivering the identity and functionality today’s medical operators require.

Sienna is one of the fastest-growing master-planned communities in the Houston MSA, with significant residential density and strong household incomes surrounding the site. The property benefits from direct exposure and access along Highway 6, a primary north-south arterial serving Missouri City and greater Fort Bend County. This corridor continues to experience sustained population growth, creating long-term demand for healthcare services and specialty providers.

The presence of MD Anderson on-site creates immediate referral synergy, daily patient traffic, and long-term stability for complementary medical users. Opportunities to lease directly above a nationally recognized healthcare institution within a newly constructed, Class A facility are rare in this submarket