5406 US-280

5406 US-280, Birmingham, AL 35242

Property Information

  • For Lease $24.00/SF/YR
  • Property Type Retail
  • Property Size 13,345 SF
  • Date Updated Jun 26, 2026

Description

Join Andrews Sports Medicine, Skin Wellness Dermatology, ENT for Kids, and Birmingham Orthodontics, in this premier medical location on Highway 280.

 

The Crossroads at Greystone offers a convenient, neighborhood center setting for your next location. Building signage and ample parking in a drive-up setting provides an easy experience for patients and visitors.

 

Multiple suite sizes are available and build out packages can be customized to your exact layout needs.

 

85,500 vehicles per day on Highway 280

 

18,800 vehicles per day on Highway 119 (Cahaba Valley Road)

 

Excellent signage (building and monument)

 

Drive up parking for a convenient patient experience

 

Multiple ingress/egress points and traffic light access to Highway 280

 

Convenient to Birmingham’s major neighborhoods: Inverness, Meadowbrook, Greystone and continued growth down Highway 280 

5 Spaces Available

#5

Space Type

Retail

Lease Rate

$24.00/SF/YR

Total Space

6,145 SF

Additional Space Type

Medical Office

Divisible Space

6,145 - 6,145 SF

Available Date

Immediate

Lease Type

NNN

Renewal Option

Yes

Sublease

No

Turnkey

No

  • VPD:
  • 85,500 vehicles per day on Highway 280

  • 18,800 vehicles per day on Highway 119 (Cahaba Valley Road) 

#B101

Space Type

Retail

Lease Rate

$24.00/SF/YR

Total Space

3,600 SF

Additional Space Type

Medical Office

Divisible Space

3,600 - 3,600 SF

Available Date

Immediate

Lease Type

NNN

Renewal Option

Yes

Sublease

No

Turnkey

No

  • VPD:
  • 85,500 vehicles per day on Highway 280

  • 18,800 vehicles per day on Highway 119 (Cahaba Valley Road) 

#B105

Space Type

Retail

Lease Rate

$24.00/SF/YR

Total Space

1,200 SF

Additional Space Type

Medical Office

Divisible Space

1,200 - 1,200 SF

Available Date

Immediate

Lease Type

NNN

Renewal Option

Yes

Sublease

No

Turnkey

No

  • VPD:
  • 85,500 vehicles per day on Highway 280

  • 18,800 vehicles per day on Highway 119 (Cahaba Valley Road) 

#D112

Space Type

Retail

Lease Rate

$24.00/SF/YR

Total Space

1,200 SF

Additional Space Type

Medical Office

Divisible Space

1,200 - 1,200 SF

Available Date

Immediate

Lease Type

NNN

Renewal Option

Yes

Sublease

No

Turnkey

No

  • VPD:
  • 85,500 vehicles per day on Highway 280

  • 18,800 vehicles per day on Highway 119 (Cahaba Valley Road) 

#D113

Space Type

Retail

Lease Rate

$24.00/SF/YR

Total Space

1,200 SF

Additional Space Type

Medical Office

Divisible Space

1,200 - 1,200 SF

Available Date

Immediate

Lease Type

NNN

Renewal Option

Yes

Sublease

No

Turnkey

No

  • VPD:
  • 85,500 vehicles per day on Highway 280

  • 18,800 vehicles per day on Highway 119 (Cahaba Valley Road) 

Contacts

Location

Located at 5406 US-280, Birmingham, AL 35242, this property is part of the Greystone neighborhood and Birmingham market.

Contact Listing Broker
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