Mayo Clinic Square

600 Hennepin Avenue, Minneapolis, MN 55403

  • For Lease Contact for pricing
  • Property Type Office - General Office
  • Property Size 217,354 SF
  • Lot Size 2.61 Acre
  • Parking Spaces Avail. 673
  • Parking Ratio 3.10 / 1,000 SF
  • Property Tenancy Multi-Tenant
  • Building Class A
  • Year Built 2004
  • Date Updated May 19, 2025

Mayo Clinic Square is a 217,354-square-foot Class A office building situated on a 2.61-acre lot in Downtown Minneapolis. Built in 2004, the property provides convenient on-site parking with 673 spaces, offering a parking ratio of 3.1 per 1,000 square feet. Designed to accommodate modern office needs, this premier office space delivers an exceptional environment for tenants seeking a professional setting in the heart of the city.

Positioned in Downtown Minneapolis, the property is surrounded by a variety of amenities and transportation options. Dining establishments such as Gold Room and Gluek's Restaurant & Bar are just steps away, while nearby hotels like the Loews Minneapolis Hotel and Embassy Suites provide convenient accommodations for visiting clients. Public transit is easily accessible, with the Warehouse District/Hennepin Avenue station approximately 0.1 miles away, and parking facilities such as Butler Park just 0.06 miles from the building. The area also offers proximity to educational institutions, including the University of St. Thomas, which is about 0.35 miles away.

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Spaces Available

Contacts

broker

Jones Lang LaSalle

broker

Jones Lang LaSalle

broker

Jones Lang LaSalle

broker

Transwestern

broker

Transwestern

Location

Getting Around

  • Walk Score ®

    92/100 Walker's Paradise
  • Transit Score ®

    85/100 Excellent Transit
  • Bike Score ®

    89/100 Very Bikeable
Powered by Walk Score ®
  • City Minneapolis, MN
  • Neighborhood Downtown Minneapolis
  • Zip Code 55403
  • Market Minneapolis St Paul

Points of Interest

  • Warehouse District/Hennepin Avenue

    0.10 miles

  • Nicollet Mall

    0.23 miles

  • Target Field - Platform 1

    0.29 miles

  • Target Field - Platform 2

    0.37 miles

  • Royalston

    0.44 miles

  • Government Plaza

    0.45 miles

  • Bassett Creek Valley

    1.09 miles

  • Cedar-Riverside

    1.37 miles

  • West Bank

    1.46 miles

  • Franklin Avenue

    1.77 miles

  • Holiday

    0.47 miles

  • BP

    1.15 miles

  • EZ Stop

    1.19 miles

  • Bobby and Steve's Auto World

    1.20 miles

  • Speedway

    1.44 miles

  • ChargePoint

    1.50 miles

  • Mobil

    1.67 miles

  • Marathon

    1.74 miles

  • Greenlots

    2.20 miles

  • Tesla Supercharger

    2.85 miles

  • Butler Park

    0.06 miles

  • 5th Street Ramp B

    0.15 miles

  • 7th Street Ramp A

    0.17 miles

  • Hawthorne Transportation Center

    0.19 miles

  • Midtown Parking Ramp

    0.19 miles

  • Underground Ramp Parking

    0.24 miles

  • 4th Street Ramp C

    0.28 miles

  • 517 Marquette Garage

    0.28 miles

  • Minneapolis Club Parking Ramp

    0.39 miles

  • 4th Street North Lot

    0.42 miles

  • Loews Minneapolis Hotel

    0.03 miles

  • Embassy Suites by Hilton Minneapolis Downtown

    0.09 miles

  • Minneapolis Marriott City Center

    0.11 miles

  • The Royal Sonesta Minneapolis Downtown

    0.14 miles

  • Hampton Inn & Suites Minneapolis/Downtown

    0.16 miles

  • AC Hotel by Marriott Minneapolis Downtown

    0.17 miles

  • Residence Inn Minneapolis Downtown/City Center

    0.20 miles

  • The Westin Minneapolis

    0.23 miles

  • The Marquette Hotel, Curio Collection by Hilton

    0.24 miles

  • The Chambers Hotel

    0.24 miles

  • Gold Room

    0.04 miles

  • Gluek's Restaurant & Bar

    0.04 miles

  • Fogo de Chao

    0.07 miles

  • Sal's on Fifth

    0.11 miles

  • Naf Naf Grill

    0.12 miles

  • Leeann Chin

    0.12 miles

  • Los Ocampo Express

    0.13 miles

  • Wood + Paddle Eatery

    0.13 miles

  • Chipotle

    0.13 miles

  • Workshop at Union

    0.14 miles

  • Wellstone International High School

    0.27 miles

  • University of St. Thomas

    0.35 miles

  • Minneapolis Community & Technical College

    0.62 miles

  • Stadium View

    0.70 miles

  • DeLaSalle High School

    0.79 miles

  • Emerson Elementary School

    0.80 miles

  • Dunwoody College of Technology

    0.87 miles

  • North Central University

    0.92 miles

  • Bethune Arts Elementary

    1.16 miles

  • The Blake School - Northrup Campus

    1.16 miles

  • New Horizon Academy

    0.53 miles

  • Child Garden Montessori

    0.67 miles

  • Summit Early Learning Center

    0.98 miles

  • Academia Elze Spanish Immersion Early Learning Center

    1.10 miles

  • Central Care for Children

    1.19 miles

  • Lucky Stars Child Care Services

    1.70 miles

  • YMCA Child Care

    2.05 miles

  • University of MN Child Development Laboratory School

    2.24 miles

  • Grandma's House Children's Center

    2.37 miles

  • KinderCare

    2.63 miles

Frequently Asked Questions

What type of office space is available to lease at Mayo Clinic Square?

In total, there is 21,672 square feet of office space for lease here. Availability at this location includes 4 Retail spaces. The property offers Multi-Tenant commercial space.

Is Mayo Clinic Square suitable for a small business?

Yes, availabilities here may be suitable for small businesses with 2 office spaces under 5,000 square feet available. Space sizes here start at 1,048 square feet.

Does Mayo Clinic Square have enough space for a large business?

Yes, availabilities here could accommodate larger businesses with 1 office space larger than 10,000 square feet available for lease. The largest office size is 10,337 SF. For a better understanding of how this space could work for you, reach out to schedule a tour.

Does Mayo Clinic Square have parking?
Yes, the property offers 673 parking spaces with a parking ratio of 3.10 / 1,000 SF.
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