301 Broadway St

301 Broadway St, Cape Girardeau, MO 63701

Property Information

  • For Lease $26.00/SF/YR
  • Property Type Office - General Office
  • Property Size 21,507 SF
  • Building Class A
  • Date Updated Jun 7, 2026

Description

301 Broadway is centrally located in the heart of downtown Cape Girardeau, one of Southeast Missouri’s most vibrant and walkable business districts. The property sits among a dynamic mix of restaurants, retail, and entertainment venues, offering convenience and energy for both employees and clients. The historic Missourian Building has long been a cornerstone of the community and continues to serve as a hub for business and media activity. Its prime location places tenants within walking distance of key amenities and just minutes from major transportation routes. Strategically positioned between St. Louis and Memphis, Cape Girardeau provides regional accessibility while maintaining a strong local workforce and business environment. Nearby parking and multiple access points make commuting and client visits simple and efficient.MAKE SURE YOU CLICK THE "Spaces" TAB Position your business in one of downtown Cape Girardeau's most recognizable landmark buildings. Located at the highly visible corner of Broadway and Lorimier, 301 Broadway offers a rare opportunity to lease flexible office and commercial space in the center of the city's business, entertainment, and dining district. Multiple suites are currently available ranging from approximately 1,250 SF to 13,500 SF, providing options for small professional offices, growing businesses, regional headquarters, training facilities, coworking concepts, and mixed-use commercial users. Existing spaces are primarily configured for office use and feature a combination of private offices, conference rooms, collaborative work areas, and support spaces. Tenants will benefit from a prominent downtown location within walking distance of restaurants, retail, financial institutions, government offices, and the riverfront. Whether you're seeking a single suite or a larger multi-floor presence, 301 Broadway offers flexibility, visibility, and a prestigious business address in the heart of Cape Girardeau.

Highlights

  • Convenient access to government offices, professional services, and regional employers
  • Corner location offering excellent visibility and exposure
  • Easy access to major regional transportation corridors
  • Existing office buildouts with private offices, conference rooms, and open workspaces
  • Flexible leasing options available
  • Historic building with distinctive architectural character
  • Ideal for professional office, corporate headquarters, medical office, educational, nonprofit, and service-based users
  • Located within Cape Girardeau's central business district
  • Multiple floor plans available to accommodate a variety of users
  • Opportunity for suite customization based on tenant needs
  • Professional image and prestigious downtown business address
  • Prominent location in the heart of Downtown Cape Girardeau
  • Suites available from 1,250 SF to 13,500 SF
  • Walkable to restaurants, coffee shops, retail, banking, and entertainment

5 Spaces Available

301 Broadway Suite 1

Space Type

Street Retail

Lease Rate

$26.00/SF/YR

Total Space

3,600 SF

Divisible Space

3,600 - 3,600 SF

Available Date

Immediate

Lease Type

Full Service

Renewal Option

Yes

Sublease

No

Position your business in one of downtown Cape Girardeau’s most iconic and high-visibility locations. This ±3,600 SF street-level space at 301 Broadway offers a rare opportunity to join a vibrant retail corridor, directly adjacent to Magnolia Bridal—one of the area’s premier destination boutiques. The space is currently configured as professional office space, providing an easy, cost-effective transition for office or service users, while offering a highly adaptable layout for retail conversion. With dual storefront entrances along Broadway, the space can be easily reimagined to create an inviting, customer-focused retail presence. Tenants will benefit from a full-service lease structure, sprinklered space, and access to shared restroom and breakroom facilities—with the option to build out private amenities if desired. Existing furniture is available, allowing for immediate occupancy and minimal upfront investment. Located within the historic Missourian Building, this space blends timeless architecture with modern functionality—ideal for retailers, boutiques, showrooms, or experiential concepts seeking a distinctive downtown presence.

Suite 2A

Space Type

Shared Space

Lease Rate

$26.00/SF/YR

Total Space

2,600 SF

Divisible Space

2,600 - 2,600 SF

Available Date

Immediate

Lease Type

Full Service

Renewal Option

Yes

Sublease

No

Elevate your business presence with this ±2,600 SF executive office suite located on the second floor of the iconic Missourian Building at 301 Broadway in downtown Cape Girardeau. This corner suite offers a rare combination of character, functionality, and privacy—ideal for professional firms seeking a distinguished workplace environment. The space features a well-appointed layout including a dedicated reception area, six spacious private offices, a private breakroom, and two in-suite restrooms. One of the offices can easily be converted into a conference room, providing flexibility to accommodate team collaboration or client meetings. Large windows throughout the suite provide abundant natural light along with seasonal views of downtown and the Mississippi River, creating an inspiring and productive work environment. With both stair and elevator access, the suite is easily accessible for employees and clients alike. Located within a historic, fully renovated building, this executive suite blends timeless architecture with modern convenience—perfect for law firms, financial services, consulting groups, or regional offices looking to make a strong impression.

Suite 2B

Space Type

Creative Office

Lease Rate

$26.00/SF/YR

Total Space

1,250 SF

Divisible Space

1,250 - 1,250 SF

Available Date

Immediate

Lease Type

Full Service

Renewal Option

Yes

Sublease

No

Position your business in a professional, character-rich environment with this well-appointed second-floor 1,250 sf office suite at 301 Broadway in downtown Cape Girardeau. Designed for flexibility and efficiency, this space is ideal for small teams, startups, or satellite offices seeking a polished presence without excess space. The suite features a welcoming reception area, one private office, and a large conference room that can easily function as a second private office if needed. A spacious open area provides additional flexibility for cubicles, collaborative workspace, or creative use—allowing tenants to tailor the layout to fit their operations. With both stair and elevator access, the suite offers convenient entry for employees and clients. Tenants also benefit from access to shared restroom facilities, helping maximize usable square footage within the suite. Located within the historic Missourian Building, this space combines timeless architecture with modern functionality—offering a unique and professional setting in the heart of downtown.

Suite 2C

Space Type

Shared Space

Lease Rate

$26.00/SF/YR

Total Space

2,625 SF

Divisible Space

2,625 - 2,625 SF

Available Date

Immediate

Lease Type

Full Service

Renewal Option

Yes

Sublease

No

Position your business in a professional, character-rich environment with this well-appointed second-floor 2,625 sf office suite at 301 Broadway in downtown Cape Girardeau. Designed for flexibility and efficiency, this space is ideal for small teams, startups, or satellite offices seeking a polished presence without excess space. The suite features a welcoming reception area, 3 private offices, and a large open area currently filled with cubicles. A spacious open area provides additional flexibility for cubicles, collaborative workspace, or creative use—allowing tenants to tailor the layout to fit their operations. With both stair and elevator access, the suite offers convenient entry for employees and clients. Tenants also benefit from access to shared restroom facilities, helping maximize usable square footage within the suite. Located within the historic Missourian Building, this space combines timeless architecture with modern functionality—offering a unique and professional setting in the heart of downtown. Pictures coming soon!

Suite 2D

Space Type

Creative Office

Lease Rate

$26.00/SF/YR

Total Space

2,900 SF

Divisible Space

2,900 - 2,900 SF

Available Date

Immediate

Lease Type

Full Service

Renewal Option

Yes

Sublease

No

Located on the second floor of the historic 301 Broadway building, this available 2,900 sf suite will be delivered in white box condition, providing tenants with a blank canvas to design and build a space tailored to their exact operational needs. Whether you're envisioning a modern office, creative studio, coworking environment, professional services firm, educational/training facility, or other commercial use, this suite offers the ability to create the ideal layout from the ground up. The ownership team is prepared to work with qualified tenants to accommodate a variety of space planning requirements. Situated in the heart of Downtown Cape Girardeau, tenants will enjoy a prestigious business address, walkable access to restaurants and retail, and the character and charm of one of the city's most recognizable historic buildings. This is an excellent opportunity for businesses seeking the efficiency of new construction within a proven downtown location.

Contacts

Location

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