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Office Space for Rent in Saint Louis, MO - 416 Listings

St. Louis, MO - Office Market Overview

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The St. Louis Metropolitan Area includes the Central West End, Midtown, and Suson Park office space submarkets. With a metropolitan population of over 2.8 million, St. Louis is part of the largest metro area in Missouri. Located at the junction of the Missouri and Mississippi Rivers, this office market is driven by a mix of transportation, biotechnology, and education sectors.

As of mid-2017, the Greater St. Louis office market encompasses over 37 million square feet of existing office space in properties larger than 50,000 square feet. St. Louis is home to nine of the10 Fortune 500 companies located in Missouri, and the growing presence of medical, pharmaceutical and bio-research companies help maintain the robust demand that drives the St. Louis commercial real estate market.

St. Louis, MO - Office Inventory Description

Home to nearly 40 colleges and universities, St. Louis produces the highly-skilled labor force that today's white-collar office employers require. With a gross metropolitan product of over $150 billion annually, the demand for office space in St. Louis remains dynamic. Nearly 59% of the office space in St. Louis is Class A or A+, while Class B office space brings another 41% of inventory to the market.

The Downtown Business District office market in St. Louis is home to some of the most prestigious trophy office properties in the metro area. Located along the Gateway Arch Park and the western shore of the Mississippi River, this submarket is home to Class A office buildings such as Bank of America Plaza, One US Bank Plaza, and the One Metropolitan Square building on 211 N. Broadway.

Saint Louis, MO Commercial Inventory Breakdown

Office Spaces

Total: 47,039,706 SF

Data provided by Yardi Matrix, properties over 50k SF, includes office with retail

By square footage range:

  • 50k to 100k SF: 9,162,259 SF / 19.48% of total office
  • 100k to 500k SF: 25,026,294 SF / 53.2% of total office
  • 500k to 1M SF: 5,935,021 SF / 12.62% of total office
  • > 1M SF: 6,916,132 SF / 14.7% of total office

By class:

  • Class A: 23,612,827 SF / 50.2% of total office
  • Class B: 18,806,288 SF / 39.98% of total office
  • Class C: 522,728 SF / 1.11% of total office

Top 10 Largest Office Buildings

in St. Louis

Office building Address Sqft Year built
Wells Fargo Advisors - One Jefferson Avenue 1 North Jefferson Avenue, 63103 2,300,000 1968
Monsanto Creve Coeur East Campus 800 North Lindbergh Blvd, 63141 1,281,553 1957
One AT&T Center 909 Chestnut Street, 63101 1,273,750 1985
One Metropolitan Square 211 North Broadway, 63102 1,040,829 1989
Emerson World Headquarters 8100 West Florissant Avenue, 63136 1,020,000 1958
Bank of America Plaza 800 Market Street, 63101 749,857 1982
Centene Clayton Campus - Hanley Tower 7620 Forsyth Blvd, 63105 659,155 2019
13045 Tesson Ferry Road 13045 Tesson Ferry Road, 63128 646,520 1978
One US Bank Plaza 505 North 7th Street, 63101 609,000 1974
Southwestern Bell Building 1010 Pine Street, 63101 570,880 1925

Most Recently-Built Office Buildings

in St. Louis

Office building Address Sqft Year built
Cortex Innovation Community - 4220 Duncan 4220 Duncan Avenue, 63110 182,068 2018
Westport Plaza - World Wide Technology Headquarters 1 World Wide Way, 63146 210,000 2017
Sunset Ridge 1515 Des Peres Road, 63131 45,300 2017
4260 Forest Park Avenue 4260 Forest Park Avenue, 63108 60,000 2016
2900 Pershall Road 2900 Pershall Road, 63136 59,000 2016
7840 Natural Bridge Road 7840 Natural Bridge Road, 63121 48,000 2016
Cortex Innovation Community - @4240 4240 Duncan Avenue, 63110 202,500 2014
St. Louis Dental Center 1500 Park Avenue, 63104 79,000 2014
4700 North Hanley Road 4700 North Hanley Road, 63134 225,668 2013
BJC @ The Commons 4249 Clayton Avenue, 63110 220,000 2013

St. Louis, MO - Green Office Space


Green building in commercial office space across major U.S. markets continues to grow. The percentage of green certified buildings has increased nearly eight-fold, from less than 5% in 2005 to nearly 40% by mid-2017.

In the 2017 National Green Building Adoption Index, St. Louis ranked 28th out of the top 30 markets, for energy-efficient office space. While just under 2% of the office buildings larger than 50,000 square feet in St. Louis are LEED-certified, another 2% are Energy Star-rated and over 3% are otherwise green certified.

The Cortex Innovation Community - Cortex I is a beautiful example of green office construction in St. Louis. Built in 2006, this 152,000-square-foot office, research & development project was awarded a LEED CS pre-certification halfway through its construction. This green office building diverted 60% of construction waste away from area landfills and has a 100% permanent CO2 sensor and control system.

St. Louis, MO's Top Office-Using Sectors

The St. Louis Metropolitan Area is home to nine Fortune 500 companies, while the greater metro area hosts and additional seven Fortune 500 company headquarters. The commercial real estate market in St. Louis is constantly growing due to demand from a diverse mix of business sectors, including transportation & manufacturing, health care & biotechnology, and aerospace.

  • Transportation & Manufacturing – Union Pacific Railroad, InBev, Nestle, United Van Lines, and General Motors are all located in the St. Louis metro area.
  • Healthcare & Biotechnology – Pfizer, the Alvin J. Siteman Cancer Center, and BJC Healthcare all contribute to the demand for white-collar office space in St. Louis.
  • Aerospace & High Tech – Tyco International, Boeing, LaunchCode and LockerDome are some of the many high-technology companies in the St. Louis metro area and one of the top office-using sectors in the city.
  • Fortune 500 Headquarters – Express Scripts, Monsanto, Centene, Graybar Electric, and Edward Jones Investments are just five of the Fortune 500 companies headquartered in St. Louis that drive the demand for commercial office space.

Saint Louis Demographics


  • Total Population920,537
  • Male Population(47.6 %) 438,523
  • Female Population(52.4 %) 482,014
  • Median Age36.40


  • Average Household Income$88,246
  • Median Household Income$47,780
  • Median Income Under 25$28,125
  • Median Income 25-44$53,437
  • Median Income 45-64$50,486
  • Median Income Over 65$35,959


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