Saint Louis, MO Office Spaces for Rent

Find your best Saint Louis, MO office space among 257 for rent listings, which average an asking price of $23.58 per square foot.

Office Market FAQs

2220-2222 S Vandeventer Ave

2220-2222 S Vandeventer Ave, Southwest Garden, St. Louis, MO
Property

Retail

2,700 SF
Availability

2 Spaces

2,700 SF
For Lease

$13.00/SF/YR
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462 North Taylor St.

462 North Taylor St., Central West End Saint Louis, St. Louis, MO
Property

Office

3,000 SF
Availability

4 Spaces

2,373 SF
For Lease

$14.75/SF/YR
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350 North Skinker Blvd

350 North Skinker Boulevard, Skinker DeBaliviere, St. Louis, MO
Property

Retail

1,761 SF
Availability

1 Space

1,761 SF
For Lease Contact for pricing
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5595 Pershing Avenue

5595 Pershing Avenue, DeBaliviere Place, St. Louis, MO
Property

Office

2,900 SF
Availability

1 Space

2,900 SF
For Lease

$16.00/SF/YR
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Frequently Asked Questions

Asking prices vary based on the property location, rating, amenities such as proximity to restaurants, cafes, and entertainment venues, as well as convenience of access to public transport, airports, and thoroughfares.

The average rent for office space in Saint Louis is $23.58 per square foot. The minimum rental rate for office space in Saint Louis is $12.45 per square foot.

The most common factor that influences cost of office space in any location is the property class rating. For example, Saint Louis office space rated Class A asks an average of $25.81 per square foot. Class B office space in Saint Louis costs $21.25 per square foot, on average. Listings of office space in Class C buildings asked an average of $16.33 per square foot.

For more details on Saint Louis office space rent and sales prices, as well as overall market quality and new construction data, see Saint Louis Office Market Trends.
Most experts recommend an average of between 75 and 150 square feet of office space per person. However, it is important to keep in mind that how much office space you ultimately need depends on your activity and how you need to use the space, as much as it does on how many people it should accommodate. If you already know what size office would best suit your needs, use the available space size filter at the top of the search page to focus your search on the best fit for you.

You’ll find a home for almost any size of business in Saint Louis, as the local office market offers a wide range of options. Office spaces currently on the market go up to as much as 392,986 square feet in size for an individual listing.
However, there is a variety of differently sized opportunities below that maximum. For your consideration, the median size of an office space for lease in Saint Louis is 3,435 square feet, and the average office space size here is 10,278 square feet.
You can find 257 office listing(s) for lease in Saint Louis, which add up to a total of 2,629,815 square feet. Availability on the market includes a variety of office use types, such as General Office, Creative Office, Medical Office, Shared Space, Restaurant.

The most common office use type currently available for lease in Saint Louis is General Office, which is offered in 153 or 59.53% of listings. The second-most frequent office use type listed here is Creative Office, which account for 13 or 5.06% of office space currently available. On the other end of the spectrum, the office use type least common among local listings is Street Retail, which is available in 1 listing(s).
You can search 6 office sublease listing(s) in Saint Louis, which amount to a total of 28,216 square feet. Sublease opportunities on the market include General Office, Creative Office, Medical Office. The Saint Louis neighborhood or submarket with the most sublease listings available is Downtown Saint Louis.
The best choice of neighborhood for your office space will greatly depend on the elements that are most relevant to your business and your employees. However, a good criterion to start with is to look at the areas of the city that have the highest concentration of office properties, as these areas are generally well connected to transit options and have a good degree of amenity availability.

In Saint Louis, the greatest concentration of office space for lease opportunities is in Downtown Saint Louis, Downtown West Saint Louis, Central West End Saint Louis.
Each individual’s commuting experience will of course be different depending on a number of factors. Check the location description details for the office listings that catch your eye, to get an overview of walkability, access to public transport, the quality of infrastructure dedicated to biking commuters, as well as the proximity to parking facilities, fuel stations, and other essential amenities.
The Saint Louis office market incorporates a mix of properties of various ages, ratings, construction grades, and other quality indicators. Roughly 47.86% of total office space listings in the city are in properties rated Class A. You will find the highest concentration of Class A office space in the Downtown Saint Louis neighborhood of Saint Louis. Class B office space accounts for 28.02% of spaces listed on the leasing market. The neighborhood with the most Class B office space is Downtown Saint Louis. Class C office space makes up 3.89% of office space available in Saint Louis.

Buildings completed in and since the year 2000 account for 3.7% of office properties in the city and incorporate a total of 150,785 square feet. About 14.81% of office space in Saint Louis is in buildings that have been renovated at least once since 2000.

Out of the office space listings currently available in Saint Louis, you can find 3 LEED-certified or LEED-proposed option(s). A total of 1 building(s) here earned a LEED-certification — certification level Silver (1).
There are, of course, a lot of things to factor in when you are looking for office space. Aspects including the accessibility of the location, the quality of the facility, the size of the space, the convenience of nearby amenities, the type and duration of the lease, and of course the cost are all part of the search and decision process. For a quick checklist of what you should take into account when researching the market, consider these seven tips for choosing the best office location for your business. Alternatively, for a comprehensive take on everything to consider when looking for office space, see our in-depth guide to finding office space for small or growing companies. The guide also includes insights from seasoned professionals and can serve as a helpful resource for growing companies, no matter their current size.
Are you looking to lease office space in the vicinity of your current location or in a particular neighborhood of Saint Louis? Using the interactive map, you can easily navigate to your preferred location and customize your search area around a specific point of interest. Select “Radius” from the Search Mode options menu, click on the map to set your search reference point, and expand the radius to select your desired search area. Browse available listings to find the best office space that meets your location, as well as other business needs.

Saint Louis, MO Office Inventory Breakdown

There are a number of factors that make a city attractive for businesses to relocate or expand, as well as for investors to enhance their portfolios through local acquisitions. Among the most important factors to consider are the size and quality of the local office market, which is an essential component of the local economy.

Total Office Space in Saint Louis: 24,577,474 Sq. Ft.

In 2025 the Saint Louis office market encompassed 24,577,474 square feet of space. Out of that total, 4,143,526 square feet were in office properties sized between 500,000 and 1,000,000 square feet. Meanwhile, 3,037,943 square feet were in office buildings sized between 50,000 and 100,000 square feet.
Class A office space makes up a 54.81% share of Saint Louis office inventory, while Class B office assets represent roughly 36.26% of the market total.

Saint Louis Office Market Breakdown by Building Size
Building Size Range	Total Square Feet	Share of Total Office
50k to 100k Sq. Ft.	3,037,943 Sq. Ft.	12.36%
100k to 500k Sq. Ft.	10,811,414 Sq. Ft.	43.99%
500k to 1M Sq. Ft.	4,143,526 Sq. Ft.	16.86%
> 1M Sq. Ft.	4,587,327 Sq. Ft.	18.66%

Saint Louis Office Market Breakdown by Building Quality Rating
Class	Total Square Feet	Share of Total Office
Class A	13,471,053 Sq. Ft.	54.81%
Class B	8,912,947 Sq. Ft.	36.26%
Class C	1,820,893 Sq. Ft.	7.41%

Data was provided by CommercialEdge, refers to properties larger than 50,000 square feet.

St. Louis, MO Office Market Overview

The St. Louis office market is robust and evolving. The city is rooted in industry and manufacturing, but healthcare and services have also grown rapidly here in the last decade. Anheuser-Busch has been a staple of the city since 1852 and it remains the North American headquarters for the beverage behemoth ABInBev. St. Louis also has several universities that have given rise to a budding biotech industry, with Washington University’s McDonnell Genome Institute being an integral part of the Human Genome Project.

St. Louis, MO in the news

Business Group to Move into WeWork Offices in Downtown St. Louis

Greater St. Louis Inc. (GSL), a local business group founded in 2021, has announced the signing of a 10-year lease deal in a 1-million-square-foot office tower in downtown St. Louis.

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Saint Louis, MO Office Spaces for Rent

2220-2222 S Vandeventer Ave

462 North Taylor St.

350 North Skinker Blvd

5595 Pershing Avenue

Frequently Asked Questions

Saint Louis, MO Office Inventory Breakdown

Total Office Space in Saint Louis: 24,577,474 Sq. Ft.

St. Louis, MO Office Market Overview

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St. Louis, MO in the news

Business Group to Move into WeWork Offices in Downtown St. Louis

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