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Saint Louis, MO Office Spaces for Rent

Find the best Saint Louis, MO office space among 304 for rent listings currently on the market.

1008 Locust Street

1008 Locust St, Downtown Saint Louis, Saint Louis, MO
Space Type

Office
For Lease

$12.95/SF/YR
1 space available / 12,600 SF
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Class A Office Spaces For Lease in the Heart of Downtown St. Louis

10 S Broadway, Downtown Saint Louis, St. Louis, MO
Space Type

Office
For Lease Contact for pricing

1 space available / 17,570 SF
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2333 S Grand Blvd

2333 S Grand Blvd, Shaw, St. Louis, MO
Space Type

Office
For Lease

$15.95/SF/YR
1 space available / 10,950 SF
View Details
Cortex 1 - Office/Lab Space For Lease

4320 Forest Park Ave, Central West End Saint Louis, St. Louis, MO
Space Type

Office
For Lease Contact for pricing

1 space available / 36,682 SF
View Details
3800 Gravois Ave

3800 Gravois Ave, Tower Grove South, St. Louis, MO
Space Type

Office
For Lease

$1,000.00/MO
1 space available / 1,918 SF
View Details
CLASS A OFFICE SPACE AVAILABLE WITHIN THE HUB OF THE CORTEX INNOVATION DISTRICT

4220 Duncan Ave, Central West End Saint Louis, St. Louis, MO
Space Type

Office
For Lease Contact for pricing

1 space available / 11,391 SF
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4513 Olive St

4513 Olive Street, Central West End Saint Louis, St. Louis, MO
Space Type

Office
For Lease

$16.50/SF/YR
1 space available / 1,200 SF
View Details

Frequently Asked Questions

In Saint Louis, office spaces range from smaller units to larger options. On average, office spaces in this area tend to be about 13,213 square feet. However, the largest listings can go up to 392,986 square feet for an individual listing. This can give you a good starting point to compare with your needs.
In Saint Louis, you have several options when it comes to leasing office space. To better understand what to look for, check out our definitive guide to finding office space for your small business or startup. Here is an overview of the most common types currently available:
- Most Common Office Type
  The most frequent subtype available for lease is General Office, which makes up 54.43% of all listings in the city.
- Second-Most Common Office Type
  The second-most common office space type listed here is Creative Office, accounting for 3.93% of available listings.
- Third-Most Common Office Type
  Up next, Data Center also makes up a significant portion of listings, offering additional options for those seeking alternative spaces.
- Rarest Office Type
  On the other end of the spectrum, the rarest type of office space among local listings is Street Retail, with only 1 listing currently available.
You can find a total of 304 listings for lease in Saint Louis, which add up to a total of 3.5 million square feet.
Generally, buildings completed since the year 2000 offer modern amenities, decor and services. This also applies to buildings that have been renovated within the same timeframe. Buildings completed in or after the year 2000 account for 6.98% of office properties in this city and incorporate a total of 234,060 square feet. Additionally, about 18.6% of office space in Saint Louis is in buildings that have been renovated at least once since 2000.

Saint Louis, MO Office Space for Rent

Office inventory

According to our listing data, Saint Louis's office market contains 23.8M square feet of space as of 2026.

Saint Louis Office Market Breakdown by Building Size
Building Size Range	Total Square Feet
50k to 100k Sq. Ft.	3.1M Sq. Ft.
100k to 500k Sq. Ft.	10.9M Sq. Ft.
500k to 1M Sq. Ft.	3.1M Sq. Ft.
> 1M Sq. Ft.	4.6M Sq. Ft.

Data was provided by Yardi Research Data, refers to properties larger than 50,000 square feet.

Properties sized 100k to 500k Sq. Ft. make up most of the local office inventory, amounting to 10.9M square feet.

Average Rent for Office Spaces

The average rent for office space in Saint Louis is $19 per square foot. However, you can find rental rates as low as $7 per square foot here, depending on what compromises you are willing to make. If you are looking for office space priced at a certain value, you can use the filters at the top of the page to look for properties within your optimal range.

The maximum rental rate is $58 per square foot among local listings currently available for lease.

Office Spaces Classes

The office space market in Saint Louis incorporates a mix of properties of various ages, ratings, construction grades, and other quality indicators. 54.53% of total office listings in this city are in properties rated Class A. Class B accounts for 37% of traditional work spaces listed on the leasing market. Class C makes up 8.46% of such listings in Saint Louis. This data is current as of 2026.

Saint Louis Office Market Breakdown by Building Class
Class	Total Square Feet	Share of Total Office
A	13M	54.53%
B	8.8M	37%
C	2M	8.46%

Data was provided by Yardi Research Data, refers to properties larger than 50,000 square feet.

The most common factor that influences the cost of renting space for your business in any location is the property class rating. For example, Saint Louis office space rated Class A asks an average of $21.21 per square foot. Class B space in Saint Louis costs $13.49 per square foot, on average. Listings of available space in Class C buildings asked an average of $12.8 per square foot.

Top Neighborhoods for Office Space

Location is everything when it comes to office spaces. Tenants place great value on well positioned properties in amenity-rich areas, potentially boosting office attendance.

In Saint Louis, the greatest concentration of lease opportunities is in Downtown Saint Louis, Forest Park South East and Downtown West Saint Louis.

Office Classes in Saint Louis, Missouri Neighborhoods

Downtown Saint Louis

Forest Park South East

Midtown Saint Louis

Class A+/A
Class B
Class C

The Downtown Saint Louis neighborhood contains the most Class A office space, attracting premium tenants and corporate headquarters. Meanwhile, the neighborhood with the most Class B space is Downtown Saint Louis, offering quality space at affordable rates.

St. Louis, MO Office Market Overview

The St. Louis office market is robust and evolving. The city is rooted in industry and manufacturing, but healthcare and services have also grown rapidly here in the last decade. Anheuser-Busch has been a staple of the city since 1852 and it remains the North American headquarters for the beverage behemoth ABInBev. St. Louis also has several universities that have given rise to a budding biotech industry, with Washington University’s McDonnell Genome Institute being an integral part of the Human Genome Project.

St. Louis, MO in the news

Business Group to Move into WeWork Offices in Downtown St. Louis

Greater St. Louis Inc. (GSL), a local business group founded in 2021, has announced the signing of a 10-year lease deal in a 1-million-square-foot office tower in downtown St. Louis.

Saint Louis, MO Office Spaces for Rent

1008 Locust Street

Class A Office Spaces For Lease in the Heart of Downtown St. Louis

2333 S Grand Blvd

Cortex 1 - Office/Lab Space For Lease

3800 Gravois Ave

CLASS A OFFICE SPACE AVAILABLE WITHIN THE HUB OF THE CORTEX INNOVATION DISTRICT

4513 Olive St