St. Louis City County, MO Office Spaces for Rent

Find the best St. Louis City County, MO office space among 260 for rent listings currently on the market.

Office Condo For Sale or Lease in Downtown St. Louis’ Terra Cotta Lofts Building

1501 Locust St, Downtown West Saint Louis, St. Louis, MO
Property

Office
Availability

1 Space

3,823 SF
For Lease Contact for pricing
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Hampton Village Plaza

60 Hampton Village Plaza, South Hampton, St. Louis, MO
Property

Retail

217,702 SF
Availability

11 Spaces

15,941 SF
Year Built

1950
For Lease

$12.00/SF/YR
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42,956 SF Available for Lease - Prime Cortex Location

4300 Duncan Avenue, Central West End Saint Louis, St. Louis, MO
Property

Office
Availability

1 Space

42,956 SF
Year Built

2008
For Lease Contact for pricing
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760 South 2nd Street

760 South 2nd Street, Downtown Saint Louis, St. Louis, MO
Property

Industrial

511,341 SF
Availability

1 Space

500,000 SF
Year Built

1906
For Lease Contact for pricing
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2220-2222 S Vandeventer Ave

2220-2222 S Vandeventer Ave, Southwest Garden, St. Louis, MO
Property

Retail

2,700 SF
Availability

2 Spaces

2,700 SF
For Lease

$13.00/SF/YR
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7110 Oakland Avenue
Hi-Pointe Business Center
7110 Oakland Avenue #200 & 210, Richmond Heights, MO
Services

Meeting Room

Private Office
Amenities

Espresso bar

High-speed internet

Office furniture

Parking

Window view
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4200 Sarpy Ave

4200 Sarpy Ave, Central West End Saint Louis, Saint Louis, MO
Property

Office

1,352 SF
Availability

1 Space

1,352 SF
Year Built

1988
For Lease

$1,402.70/MO
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St. Louis City County, MO Office Inventory Breakdown

There are a number of factors that make a city attractive for businesses to relocate or expand, as well as for investors to enhance their portfolios through local acquisitions. Among the most important factors to consider are the size and quality of the local office market, which is an essential component of the local economy.

Total Office Space in Saint Louis: 24,794,965 Sq. Ft.

In 2025 the Saint Louis office market encompassed 24,794,965 square feet of space. Out of that total, 4,143,526 square feet were in office properties sized between 500,000 and 1,000,000 square feet. Meanwhile, 3,255,434 square feet were in office buildings sized between 50,000 and 100,000 square feet.
Class A office space makes up a 54.6% share of Saint Louis office inventory, while Class B office assets represent roughly 36.16% of the market total.

Saint Louis Office Market Breakdown by Building Size
Building Size Range	Total Square Feet	Share of Total Office
50k to 100k Sq. Ft.	3,255,434 Sq. Ft.	13.13%
100k to 500k Sq. Ft.	10,811,414 Sq. Ft.	43.6%
500k to 1M Sq. Ft.	4,143,526 Sq. Ft.	16.71%
> 1M Sq. Ft.	4,587,327 Sq. Ft.	18.5%

Saint Louis Office Market Breakdown by Building Quality Rating
Class	Total Square Feet	Share of Total Office
Class A	13,538,384 Sq. Ft.	54.6%
Class B	8,964,947 Sq. Ft.	36.16%
Class C	1,919,053 Sq. Ft.	7.74%

Data was provided by CommercialEdge, refers to properties larger than 50,000 square feet.

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St. Louis City County, MO Office Spaces for Rent

Office Condo For Sale or Lease in Downtown St. Louis’ Terra Cotta Lofts Building

Hampton Village Plaza

42,956 SF Available for Lease - Prime Cortex Location

760 South 2nd Street

2220-2222 S Vandeventer Ave

7110 Oakland Avenue

4200 Sarpy Ave

St. Louis City County, MO Office Inventory Breakdown

Total Office Space in Saint Louis: 24,794,965 Sq. Ft.

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