Sanibel, Lee County, FL Commercial Real Estate for Lease and Sale

Explore 6 listing(s) of commercial real estate in Sanibel, Lee County, FL to find the best space for your business.

Islander Center

2407 Periwinkle Way, Sanibel, FL
Space Type

Retail
For Lease

$25.00 - $35.00/SF/YR
2 spaces available / 843 - 2,214 SF
View Details
2491 Palm Ridge Road

2491 Palm Ridge Road, Sanibel, FL
Space Type

Office
For Lease

$20.00/SF/YR
1 space available / 1,467 SF
View Details
1,200 SF Available In Building #1. Move-in Ready.

1149 Periwinkle Way, Sanibel, FL
Space Type

Office
For Lease Contact for pricing

1 space available / 1,200 SF
View Details
Medical/Office space available for lease: 3,226 SF

4301 Sanibel Captiva Rd, Sanibel, FL
Space Type

Other
For Lease Contact for pricing

1 space available / 3,226 SF
View Details
1509 Periwinkle Way

1509 Periwinkle Way, Sanibel, FL
Space Type

Retail
For Lease Contact for pricing

1 space available / 3,834 SF
View Details
Sanbel-Captiva Medical Center

4301 Sanibel Captiva Road, Sanibel, FL
Space Type

Office
For Lease Contact for pricing

2 spaces available / 2,174 - 3,226 SF
View Details

Frequently Asked Questions

CommercialCafe’s CRE offering in Sanibel is enabled by a network of 3 active brokers from 3 different firms, ensuring a wide variety of listings. Working with an experienced professional can make a real difference. Learn more about the benefits of working with a broker.

To get in touch with a broker, use the "Contact Property" button on this search page or fill in the contact form provided on each individual property’s listing page.
The profitability of a commercial real estate investment depends on a multitude of factors working together. These factors include the quality of the asset itself, local market conditions, the state of the local economy and the demand for that particular type of commercial property, to name a few.

Sanibel, Lee County, FL Commercial Space Listings

Commercial Space for Lease - Breakdown

The 6 listings for commercial real estate currently available for rent in Sanibel add up to 12,176 square feet across various property types. Here's a breakdown of the available space by category:

Property Type	Count of Listings	Total Sq. Ft.
Office	4	5,893
Retail	1	3,057
Other	1	3,226

Office properties:

The market has 4 active office listings, encompassing 5,893 square feet.
Sanibel office spaces currently listed on CommercialCafe represent 66% of the total commercial real estate market in Sanibel, compared to an average of 53% across all markets tracked by CommercialCafe.

Retail Space:

There is 1 retail listing available, adding up to a total of 3,057 square feet.
Retail spaces account for approximately 16% of the local commercial market, while the average share taken up by retail in all U.S. markets is 46%.

The data presented in this section was last updated as of October 07, 2026

Sanibel, Lee County, FL Commercial Real Estate for Lease and Sale

Islander Center

2491 Palm Ridge Road

1,200 SF Available In Building #1. Move-in Ready.

Medical/Office space available for lease: 3,226 SF

1509 Periwinkle Way

Sanbel-Captiva Medical Center

Frequently Asked Questions

Sanibel, Lee County, FL Commercial Space Listings

Commercial Space for Lease - Breakdown

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