Beaufort County, SC Commercial Real Estate for Lease and Sale
Explore 62 listing(s) of commercial real estate in Beaufort County, SC to find the best space for your business.
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109 Old Salem Rd, Beaufort, SCProperty Type- Other
For Sale- $4,000,000
Built in 1999 / Property size 34,897 SF -
5 Enterprise Ln, Hilton Head Island, SC -
1264 Ribaut Rd, Suite 302, Beaufort, SCSpace Type- Office
For Lease- $25.00/SF/YR
1 space available / 1,484 SF -
1101 - 1523 Main Street, Hilton Head Island, SC -

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435 William Hilton Pkwy, Hilton Head Island, SC -
336 Robert Smalls Parkway, Beaufort, SC -
5 Buck Island Rd, Bluffton, SCSpace Type- Office
For Lease- $25.00/SF/YR
1 space available / 17,525 SF -
Okatie Village Drive, Okatie, SCProperty Type- VacantLand
For Sale- $700,000
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100 Exchange Street, Hilton Head Island, SCSpace Type- Office
For Lease- $22.50/SF/YR
1 space available / 1,726 SF -
29 Hunter Rd, Hilton Head Island, SCSpace Type- Industrial
For Lease- $16.50/SF/YR
1 space available / 4,800 SF -
8 Lafayette Pl, Hilton Head Island, SCSpace Type- Office
For Lease- $17.00/SF/YR
1 space available / 3,025 SF -
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1 Carecore Drive, Bluffton, SCSpace Type- Office
For Lease- $25.00/SF/YR
1 space available / 3,706 SF -
27 Towne Drive, Bluffton, SCSpace Type- Office
For Lease- $23.00/SF/YR
2 spaces available / 2,313 - 2,516 SF -
109 & 111 Bluffton Road, Bluffton, SCProperty Type- VacantLand
For Sale- $6,750,000
Property size 100,000 SF -
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23B Shelter Cove Lane, Hilton Head Island, SC -
23 Main Street, Suite 303, Hilton Head Island, SCProperty Type- Office
For Sale- $375,000
Property size 1,213 SF -
12 Cardinal Rd, Hilton Head Island, SC -
4380 Bluffton Pkwy, Bluffton, SC -
1050 Fording Island Rd, Suite D, Bluffton, SCSpace Type- Retail
For Lease- $28.00/SF/YR
1 space available / 1,500 SF -
110 Traders Cross 1st Floor, Bluffton, SCRegus - Hilton Head
RegusSpace Type- Private Offices
For Lease-
From $599/month
Space for 1 to 15 people -
361 Shanklin Rd, Laurel Bay, Beaufort, SCProperty Type- Retail
For Sale- $1,000,000
Built in 2017 / Property size 8,000 SF -
4101 Main St, Suites E & F , Hilton Head Island, SCProperty Type- Office
For Sale- $1,348,000
Built in 2001 / Property size 3,600 SF -
303 Bleecker Street South, Bluffton, Bluffton,,, SCProperty Type- Other
For Sale- $6,300,000
Built in 2021 / Property size 10,656 SF -
21 New Orleans Rd Ste C & D, Hilton Head Island, SCProperty Type- Office
For Sale- $850,000
Built in 1984 / Property size 4,419 SF -
304, Beaufort, SC -
189 Sea Island Pkwy, Beaufort, SCSpace Type- Office
For Lease- $22.00/SF/YR
1 space available / 1,250 SF -
4101 Main St, Suites E & F , Hilton Head Island, SCSpace Type- Office
For Lease- $17.00 - $19.00/SF/YR
3 spaces available / 1,286 - 3,600 SF -
32 Office Park Road, Hilton Head Island, SCSpace Type- Private Offices
For Lease-
From $399/month
Space for 1 to 15 people -
Evan Way, Bluffton, SCProperty Type- VacantLand
For Sale- $1,376,000
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500 Carteret Street, Beaufort, SC -
1119 Pick Pocket Plantation Drive, Beaufort, SCProperty Type- Other
For Sale- $6,000,000
Built in 1999 / Property size 48,288 SF -
330 Robert Smalls Pkwy, Beaufort, SC -
2 Westbury Park Way, Bluffton, SCSpace Type- Office
For Lease- $30.00 - $32.00/SF/YR
2 spaces available / 1,790 - 3,870 SF -
350 Shanklin Rd, Laurel Bay, Beaufort, SC -
1127 Fording Island Rd, Bluffton, SC -
May River Rd & Hwy 170, Bluffton, SCProperty Type- VacantLand
For Sale- $1,595,000
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1556 Salem Rd, Beaufort, SCProperty Type- VacantLand
For Sale- $3,250,000
Built in 1973 / Property size 4.3 Acre -
11 Palmetto Bay Road, Hilton Head Island, SC -
1520 Ribaut Rd, Port Royal, SCProperty Type- VacantLand
For Sale- $540,825
Built in 1940 / Property size 1,020 SF -
386 Spanish Wells Rd, Unit B-3, Hilton Head Island, SCSpace Type- Office
For Lease- $3,000.00/MO
1 space available / 2,175 SF -
Ribaut Rd, Port Royal, SCProperty Type- VacantLand
For Sale- Subject To Offer
Built in 2016 / Property size 9,291 SF -
890 William Hilton Pkwy, Hilton Head Island, SC -
20 Capital Dr, Hilton Head Island, SCSpace Type- Industrial
For Lease- $16.00/SF/YR
1 space available / 13,500 SF -
101 Buckwalter Place Blvd, Bluffton, SC -
5 Blue Crab Street, Bluffton, SCProperty Type- VacantLand
For Sale- $439,000
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500 Carteret Street #D, Beaufort, SCBASEcamp - Beaufort
BASEcampSpace Type- Private Offices
For Lease-
From $500/month
Space for 1 to 4 people -
139 Robert Smalls Parkway, Beaufort, SC -
129 Towne Drive, Bluffton, SC -
70 Pope Avenue, Hilton Head Island, SC -
10 Target Rd, Hilton Head Island, SCProperty Type- Other
For Sale- $5,800,000
Property size 23,957 SF -
10 Hospital Center Commons #400, Hilton Head Island, SCThe Common Loft
The Common LoftSpace Type- Desks
For Lease-
From $40/day