Beaufort County, SC Commercial Real Estate for Lease and Sale
Explore 72 listing(s) of commercial real estate in Beaufort County, SC to find the best space for your business.
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2 Westbury Park Way, Bluffton, SCSpace Type- Office
For Lease- $30.00 - $32.00/SF/YR
2 spaces available / 1,790 - 3,870 SF -
1 Carecore Drive, Bluffton, SCSpace Type- Office
For Lease- $25.00/SF/YR
1 space available / 3,706 SF -
100 Exchange Street, Hilton Head Island, SCSpace Type- Office
For Lease- $22.50/SF/YR
1 space available / 1,726 SF -
2 Park Lane , Hilton Head Island, SCSpace Type- Office
For Lease- $17.00/SF/YR
1 space available / 2,615 SF -

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4101 Main St, Suites E & F , Hilton Head Island, SCProperty Type- Office
For Sale- $1,348,000
Built in 2001 / Property size 3,600 SF -
34 New Orleans Rd, Hilton Head Island, SCProperty Type- Office
For Sale- $1,650,000
Built in 2014 / Property size 3,788 SF -
1119 Pick Pocket Plantation Drive, Beaufort, SCProperty Type- Other
For Sale- $6,000,000
Built in 1999 / Property size 48,288 SF -
109 Old Salem Rd, Beaufort, SCProperty Type- Other
For Sale- $4,000,000
Built in 1999 / Property size 34,897 SF -
5 Enterprise Ln, Hilton Head Island, SC -
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29 Hunter Rd, Hilton Head Island, SCSpace Type- Industrial
For Lease- $16.50/SF/YR
1 space available / 4,800 SF -
1520 Ribaut Rd, Port Royal, SCProperty Type- VacantLand
For Sale- $540,825
Built in 1940 / Property size 1,020 SF -
110 Traders Cross 1st Floor, Bluffton, SCRegus - Hilton Head
RegusSpace Type- Private Offices
For Lease-
From $749/month
Space for 1 to 15 people -
701 Greene St, Beaufort, SCProperty Type- Other
For Sale- $2,100,000
Built in 1780 / Property size 2,737 SF -
435 William Hilton Pkwy, Hilton Head Island, SC -
5 Dunmore Court, Hilton Head Island, SCProperty Type- Office
For Sale- $1,950,000
Built in 1999 / Property size 9,600 SF -
225-235 Gibbet Rd, Bluffton, SCSpace Type- Industrial
For Lease- $21.00/SF/YR
1 space available / 1,236 SF -
21 New Orleans Rd Ste C & D, Hilton Head Island, SCProperty Type- Office
For Sale- $850,000
Built in 1984 / Property size 4,419 SF -
336 Robert Smalls Parkway, Beaufort, SC -
876, 878 and 880 Fording Island Road, Bluffton, SCSpace Type- Retail
For Lease- $24.00/SF/YR
1 space available / 1,575 SF -
27 Towne Drive, Bluffton, SCSpace Type- Office
For Lease- $23.00/SF/YR
2 spaces available / 2,313 - 2,516 SF -
4380 Bluffton Pkwy, Bluffton, SC -
16 Finch St, Hilton Head Island, SCSpace Type- Industrial
For Lease- $22.00/SF/YR
1 space available / 8,495 SF -
5 Buck Island Rd, Bluffton, SCSpace Type- Office
For Lease- $25.00/SF/YR
1 space available / 17,525 SF -
5 Blue Crab Street, Bluffton, SCProperty Type- VacantLand
For Sale- $439,000
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1101 - 1523 Main Street, Hilton Head Island, SC -
255 New Riverside Village Way, Bluffton, SCSpace Type- Office
For Lease- $43.00/SF/YR
1 space available / 1,899 SF -
303 Bleecker Street South, Bluffton, Bluffton,,, SCProperty Type- Other
For Sale- $6,300,000
Built in 2021 / Property size 10,656 SF -
386 Spanish Wells Rd, Unit B-3, Hilton Head Island, SCSpace Type- Office
For Lease- $3,000.00/MO
1 space available / 2,175 SF -
23B Shelter Cove Lane, Hilton Head Island, SC -
3 Regency Pkwy, Hilton Head Island, SCProperty Type- Retail
For Sale- $849,000
Built in 1987 / Property size 2,250 SF -
365 Red Cedar Street, Unit 501, Bluffton, SCSpace Type- Industrial
For Lease- $18.00/SF/YR
1 space available / 3,386 SF -
1264 Ribaut Rd, Suite 302, Beaufort, SCSpace Type- Office
For Lease- $25.00/SF/YR
1 space available / 1,484 SF -
375 Buckwalter Place Blvd, Bluffton, SCProperty Type- VacantLand
For Sale- $565,000
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235 Okatie Village Dr, Okatie, SCProperty Type- VacantLand
For Sale- $748,000
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109 & 111 Bluffton Road, Bluffton, SCProperty Type- VacantLand
For Sale- $6,750,000
Property size 100,000 SF -
304, Beaufort, SC -
20 Capital Dr, Hilton Head Island, SCSpace Type- Office
For Lease- $16.00/SF/YR
1 space available / 8,500 SF -
12 Cardinal Rd, Hilton Head Island, SC -
386 Spanish Wells Rd, Unit B-3, Hilton Head Island, SCProperty Type- Office
For Sale- $450,000
Built in 1986 / Property size 2,175 SF -
4101 Main St, Suites E & F , Hilton Head Island, SCSpace Type- Office
For Lease- $17.00 - $19.00/SF/YR
3 spaces available / 1,286 - 3,600 SF -
32 Office Park Road, Hilton Head Island, SCSpace Type- Private Offices
For Lease-
From $339/month
Space for 1 to 15 people -
190 Sea Island Pkwy, Beaufort, SC -
265 Sea Island Parkway, Beaufort, SC -
10 Hospital Center Commons #400, Hilton Head Island, SCThe Common Loft - 10 Hospital Center Commons
The Common LoftSpace Type- Desks
For Lease-
From $40/day
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2441 Boundary St, Beaufort, SCProperty Type- Industrial
For Sale- $2,710,000
Built in 1976 / Property size 10,000 SF -
Evan Way, Bluffton, SCProperty Type- VacantLand
For Sale- $1,376,000
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100 Lost Island Road, Beaufort, SCProperty Type- VacantLand
For Sale- $75,000
Property size 0.94 Acre -
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2441 Boundary St, Beaufort, SCSpace Type- Industrial
For Lease- $15.77/SF/YR
1 space available / 10,000 SF -
70 Pope Avenue, Hilton Head Island, SC -
1556 Salem Rd, Beaufort, SCProperty Type- VacantLand
For Sale- $3,250,000
Built in 1973 / Property size 4.3 Acre -
19 Market, Beaufort, SCSpace Type- Office
For Lease- $22.00/SF/YR
1 space available / 1,350 SF