Port St. Lucie, FL Commercial Real Estate for Lease and Sale
Explore 102 listing(s) of commercial real estate in Port St. Lucie, FL to find the best space for your business.
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300 NW Bethany Drive # 320, St. Lucie West, Port St. Lucie, FLSpace Type- Office
For Lease- $18.00/SF/YR
1 space available / 2,000 SF -
584 NW University Blvd Suite 350 584 Northwest University Boulevard, Port St. Lucie, FLProsperity Business Suites
Prosperity Business Suites -
1401-1421 Southwest Biltmore Street, River Park, Port St. Lucie, FLSpace Type- Industrial
For Lease- $1,300.00/SF/MO
2 spaces available / 1,000 SF -
10460 Southwest Fellowship Way, Tradition, Port St. Lucie, FL -

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145 NW Central Park Plz, Port Saint Lucie, FL 34986-2482, St. Lucie West, Port Saint Lucie, FLSpace Type- Office
For Lease- $1,350.00 - $4,277.50/MO
2 spaces available / 432 - 1,711 SF -
10570 S US Highway 1, Downtown Port St. Lucie, Port Saint Lucie, FLSpace Type- Office
For Lease- $21.00/SF/YR
1 space available / 1,295 SF -
2095 NW Commerce Lakes Dr, Reserve Commerce Park, Port Saint Lucie, FLSpace Type- Flex Space
For Lease- $19.50/SF/YR
2 spaces available / 11,827 SF -
870 St. Lucie W. Boulevard, Lake Forest Pointe, Port St. Lucie, FLSpace Type- Retail
For Lease- $30.00 - $45.00/SF/YR
3 spaces available / 1,965 - 3,437 SF -
7630 South U.S. Highway 1, Spanish Lakes, Port St. Lucie, FLSpace Type- Retail
For Lease- $23.00 - $24.00/SF/MO
4 spaces available / 928 - 1,849 SF -
1290 SE Port St Lucie Blvd, Sandpiper Bay, Port Saint Lucie, FL -
Hegener Dr, Southern Grove, Port St. Lucie, FL -
1860 Southwest Fountainview Boulevard #100, Port St. Lucie, FLW Executive Suites - 1860 SW Fountainview Boulevard
W Executive Suites -
SW Becker Rd & SW Village Pkwy, Southern Grove, Port St. Lucie, FL -
2120-2130 SW Gatlin Blvd, Newport Isle, Port St. Lucie, FL -
1880 SW Fountainview Blvd., The Belmont at St Lucie West, Port St. Lucie, FL -
US-1 & Saegar Avenue, Lake Charles, Port St Lucie, FL -
2155 Settle Avenue, Reserve Commerce Park, Port St. Lucie, FLSpace Type- Industrial
For Lease- $16.00 - $16.50/SF/YR
2 spaces available / 1,700 - 2,550 SF -
605 NW Prima Vista Blvd, River Park, Port St. Lucie, FL -
826 NE Camino St, River Park, Port St. Lucie, FL -
2120-2130 SW Gatlin Blvd, Newport Isle, Port St. Lucie, FL -
SW Becker Rd & SW Village Pkwy, Southern Grove, Port St. Lucie, FL -
247-295 Port St. Lucie Boulevard, Thornhill, Port St. Lucie, FL -
10512-10914 Southwest Village Pkwy, Tradition, Port St. Lucie, FL -
200 SW Peacock Blvd Port St, Lake Charles, Port St. Lucie, FL -
2250 SW Gatlin Blvd, Portofino Isles, Port Saint Lucie, FL -
3201 SW PORT ST LUCIE, Villas of Windmill Point, Port St. Lucie, FL -
7528 US-1, Spanish Lakes, Port St. Lucie, FLSpace Type- Retail
For Lease- $21.00/SF/YR
4 spaces available / 1,283 - 1,750 SF -
1125 SE Port St. Lucie Blvd, Morningside, Port St. Lucie, FLSpace Type- Retail
For Lease- $20.00 - $27.08/SF/YR
2 spaces available / 1,000 - 2,400 SF -
3001 SW Port St Lucie Blvd, Parks Edge, Port St. Lucie, FLProperty Type- Retail
For Sale- $4,580,000
Built in 2018 / Property size 7,250 SF -
11530 SW Village Pkwy, Southern Grove, Port St. Lucie, FL -
202-204 SW Port Street Lucie Blvd, Thornhill, Port St. Lucie, FL -
1333 St Lucie W Blvd, St. Lucie West, Port St. Lucie, FL -
3453 SW Darwin Blvd, Sawgrass Lakes, Port Saint Lucie, FLProperty Type- Other
For Sale- $125,000
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648 Southwest Port Saint Lucie Boulevard, Port St. Lucie, FL -
2250 SW Gatlin Boulevard, Newport Isle, Port St. Lucie, FL -
9100-9198 US Highway 1, Port St. Lucie Industrial Park, Port St. Lucie, FL -
Tilton Road, Spanish Lakes, Port St. Lucie, FL -
905 E Prima Vista Blvd, River Park, Port St. Lucie, FL -
501 Southwest Port Saint Lucie Boulevard, Oak Hammock, Port St. Lucie, FLSpace Type- Office
For Lease- $24.00/SF/YR
1 space available / 1,000 SF -
1880 SW Fountainview Blvd., The Belmont at St Lucie West, Port St. Lucie, FL -
St Lucie West, St. Lucie West, Port St. Lucie, FL -
7528 US-1, Spanish Lakes, Port St. Lucie, FL -
12050 SW Tom Mackie Blvd, Southern Grove, Port St. Lucie, FLSpace Type- Industrial
For Lease- $11.00 - $20.00/SF/YR
8 spaces available / 6,017 - 127,634 SF -
10753 S US Highway 1, Sandpiper Bay, Port Saint Lucie, FL -
3203 SW Port St. Lucie Boulevard, Gatlin, Port St. Lucie, FLSpace Type- Retail
For Lease- $22.00/SF/YR
3 spaces available / 900 - 1,256 SF -
Becker Rd & I-95 Port St Lucie, Tesoro, Port St. Lucie, FL -
1631 SW Gatlin Blvd, Oak Hammock, Port St. Lucie, FLSpace Type- Office
For Lease- $25.00/SF/YR
1 space available / 1,288 SF -
10570 South Federal Highway, Port St. Lucie, FLW Executive Suites - 10570 South Federal Highway
W Executive Suites -
10753 S US Highway 1, Sandpiper Bay, Port Saint Lucie, FL