Port St. Lucie, FL Commercial Real Estate for Lease and Sale
Explore 100 listing(s) of commercial real estate in Port St. Lucie, FL to find the best space for your business.
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1901 SW Biltmore St, Thornhill, Port Saint Lucie, FLSpace Type- Industrial
For Lease- $1,000.00/MO
1 space available / 1,000 SF -
870 St. Lucie W Blvd, Lake Forest Pointe, Port St. Lucie, FLSpace Type
- Health Care, Retail
For Lease- $30.00 - $45.00/SF/YR
3 spaces available / 1,965 - 3,437 SF -
8443 S US 1, River Park, Port St. Lucie, FLSpace Type- Retail
For Lease- $15.75/SF/YR
1 space available / 2,500 SF -
1309 SW Gatlin Boulevard, Oak Hammock, Port St. Lucie, FL -

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2095 NW Commerce Lakes Dr, Reserve Commerce Park, Port Saint Lucie, FLSpace Type- Flex Space
For Lease- $19.50/SF/YR
2 spaces available / 11,827 SF -
1801 SE Hillmoor Drive A-102, Downtown Port St. Lucie, Port Saint Lucie, FLSpace Type- Office
For Lease- $24.00/SF/YR
1 space available / 1,530 SF -
1250 - 1264 Southwest Biltmore Street, River Park, Port St. Lucie, FLProperty Type- Industrial
For Sale- $950,000
Built in 2006 / Property size 10,922 SF -
1401 Southeast Huffman Road, Port St. Lucie Industrial Park, Port St. Lucie, FLSpace Type- Land
For Lease- $2.06/SF/YR
1 space available / 46,609 SF -
774 SE Port St Lucie Blvd, Thornhill, Port Saint Lucie, FLProperty Type- VacantLand
For Sale- $1,300,000
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Tuckpoint Business Park - 660-664 NW Enterprise Dr, St. Lucie West, Port St. Lucie, FL -
7630 South U.S. Highway 1, Spanish Lakes, Port St. Lucie, FLSpace Type- Retail
For Lease- $23.00 - $24.00/SF/MO
4 spaces available / 928 - 1,849 SF -
SW Port St Lucie Blvd, Oak Hammock, Port Saint Lucie, FLSpace Type- Retail
For Lease- $22.00 - $31.00/SF/YR
2 spaces available / 1,165 - 2,124 SF -
6560 South Federal Highway, Oleander Pines, Port St. Lucie, FLSpace Type- Office
For Lease- $20.00/SF/YR
2 spaces available / 1,625 - 3,250 SF -
1260 SE Industrial Blvd, Port St. Lucie Industrial Park, Port Saint Lucie, FLSpace Type- Industrial
For Lease- $1,450.00/SF/MO
1 space available / 1,000 SF -
7121 S US Highway 1, River Park, Port Saint Lucie, FLSpace Type- Retail
For Lease- $12.00 - $14.00/SF/YR
3 spaces available / 8,300 - 21,126 SF -
1250 - 1264 Southwest Biltmore Street, River Park, Port St. Lucie, FLSpace Type- Industrial
For Lease- $1,750.00/MO
1 space available / 1,235 SF -
10460 Southwest Fellowship Way, Tradition, Port St. Lucie, FLProperty Type- VacantLand
For Sale- Subject To Offer
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10460 Southwest Fellowship Way, Tradition, Port St. Lucie, FL -
482 NW Lake Whitney Pl, St. Lucie West, Port Saint Lucie, FLSpace Type- Industrial
For Lease- $19.00/SF/YR
1 space available / 1,776 SF -
266 NW Peacock Blvd Unit 204 -205, St. Lucie West, FLProperty Type- Office
For Sale- $1,000,000
Built in 2007 / Property size 4,324 SF -
10111 U.S. 1, Morningside, Port St. Lucie, FLSpace Type- Retail
For Lease- $175,000.00/YR
1 space available / 4,352 SF -
5505 West Midway Road, St. James, Port St. Lucie, FLProperty Type- VacantLand
For Sale- $3,950,000
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870 St. Lucie W Blvd, Lake Forest Pointe, Port St. Lucie, FL -
870-910 SW St. Lucie Blvd., Lake Forest Pointe, PSL, FLSpace Type- Retail
For Lease- $45.00/SF/YR
1 space available / 2,496 SF -
2400 Southeast Leithgow Street, Eastport St. Lucie, Port St. Lucie, FL -
264 NW Peacock Blvd, St. Lucie West, Port Saint Lucie, FLSpace Type- Office
For Lease- $18.00/SF/YR
1 space available / 935 SF -
2100 SE Hillmoor Drive Unit 205B, Eastlake Village, Port St. Lucie, FLSpace Type- Office
For Lease- $22.00/SF/YR
1 space available / 833 SF -
1260 SE Industrial Blvd, Port St. Lucie Industrial Park, Port Saint Lucie, FLProperty Type- Industrial
For Sale- $2,200,000
Built in 2003 / Property size 10,000 SF -
2200 Southwest Del Rio Boulevard, Oak Hammock, Port St. Lucie, FLProperty Type- Unassigned
For Sale- $7,900,000
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460-466 SW Port St Lucie Blvd, Oak Hammock, Port Saint Lucie, FLSpace Type- Retail
For Lease- $14.00 - $29.00/SF/YR
3 spaces available / 654 - 1,739 SF -
300 NW Bethany Drive # 320, St. Lucie West, Port St. Lucie, FLSpace Type- Office
For Lease- $18.00/SF/YR
1 space available / 2,000 SF -
1060 Southwest Bayshore Boulevard, River Park, Port St. Lucie, FLProperty Type- Retail
For Sale- $255,000
Built in 1998 / Property size 800 SF -
8241 Business Park Dr, River Park, Port Saint Lucie, FLSpace Type- Industrial
For Lease- $18.00/SF/MO
1 space available / 2,100 SF -
130 Southeast Entrada Avenue, River Park, Port St. Lucie, FLProperty Type- Retail
For Sale- $1,300,000
Built in 1980 / Property size 3,044 SF -
1887 Southeast Port Saint Lucie Boulevard, Morningside, Port St. Lucie, FLSpace Type- Office
For Lease- $25.00/SF/YR
1 space available / 3,674 SF -
1901 Southwest Biltmore Street, Thornhill, Port St. Lucie, FLSpace Type- Industrial
For Lease- $1,600.00/MO
1 space available / 1,000 SF -
584 Northwest University Boulevard, St. Lucie West, Port St. Lucie, FLSpace Type- Office
For Lease- $27.00/SF/YR
1 space available / 4,200 SF -
12801 Williams Road, Egan Grove, Port St. Lucie, FLProperty Type- VacantLand
For Sale- Call for Offers
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2100 SE Hillmoor Drive Unit 204A, Eastlake Village, Port St. Lucie, FLSpace Type- Office
For Lease- $29.20/SF/YR
1 space available / 940 SF -
Crosstown Pkwy, Southern Grove, Port St. Lucie, FL -
870 St. Lucie W. Boulevard, Lake Forest Pointe, Port St. Lucie, FLSpace Type- Retail
For Lease- $30.00 - $45.00/SF/YR
3 spaces available / 1,965 - 3,437 SF -
751 NW Airoso Blvd, River Park, Port Saint Lucie, FL -
544 NW University Boulevard Unit 103, St. Lucie West, Port St. Lucie, FLProperty Type- Office
For Sale- $275,000
Built in 2006 / Property size 1,056 SF -
NWC of Becker Rd & SW Village Pkwy, Southern Grove, Port St Lucie, FL -
2400 SE Leithgow St, Eastport St. Lucie, Port St. Lucie, FLProperty Type- VacantLand
For Sale- $2,350,000
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1401-1421 Southwest Biltmore Street, River Park, Port St. Lucie, FLSpace Type- Industrial
For Lease- $1,300.00/SF/MO
2 spaces available / 1,000 SF -
1285 SW Del Rio Blvd, Oak Hammock, Port St. Lucie, FLProperty Type- Retail
For Sale- $95,000
Built in 2007 / Property size 1,100 SF -
Hegener Dr, Southern Grove, Port St. Lucie, FL -
145 NW Central Park Plz, Port Saint Lucie, FL 34986-2482, St. Lucie West, Port Saint Lucie, FLSpace Type- Office
For Lease- $1,350.00 - $4,277.50/MO
2 spaces available / 432 - 1,711 SF -
201 SW Port St Lucie Blvd, Thornhill, Port Saint Lucie, FLSpace Type- Office
For Lease- $595.00/MO
1 space available / 100 SF -
584 NW University Blvd Suite 350 584 Northwest University Boulevard, Port St. Lucie, FLProsperity Business Suites
Prosperity Business Suites -
7630 S US Highway 1, Spanish Lakes, Port St. Lucie, FLSpace Type- Retail
For Lease- $23.00 - $24.00/SF/YR
4 spaces available / 928 - 1,849 SF -
1459 SE Village Green Dr # A12, Port St. Lucie Industrial Park, Port Saint Lucie, FLProperty Type- Industrial
For Sale- $235,000
Built in 1984 / Property size 814 SF