Port St. Lucie, FL Commercial Real Estate for Lease and Sale
Explore 98 listing(s) of commercial real estate in Port St. Lucie, FL to find the best space for your business.
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201 SW Port St Lucie Blvd, Thornhill, Port Saint Lucie, FLSpace Type- Office
For Lease- $26.00 - $71.40/SF/YR
2 spaces available / 100 - 900 SF -
584 NW University Blvd Suite 350 584 Northwest University Boulevard, Port St. Lucie, FL -
2134 Commerce Lakes Drive, Reserve Commerce Park, Port St. Lucie, FLProperty Type- Industrial
For Sale- $5,200,000
Property size 7,475 SF -
1309 SW Gatlin Boulevard, Oak Hammock, Port St. Lucie, FL -

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NW Lake Whitney Place, St. Lucie West, Port St. Lucie, FL -
870 St. Lucie W Blvd, Lake Forest Pointe, Port St. Lucie, FL -
7434 S Federal Hwy, Spanish Lakes, Port St. Lucie, FLSpace Type- Office
For Lease- $23.11/SF/YR
1 space available / 1,350 SF -
870-910 St Lucie W Blvd, Lake Forest Pointe, Port St. Lucie, FLSpace Type
- Retail
For Lease- $45.00/SF/YR
1 space available / 2,496 SF -
1801 SE Hillmoor Drive A-102, Downtown Port St. Lucie, Port Saint Lucie, FLSpace Type- Office
For Lease- $28.00/SF/YR
1 space available / 1,530 SF -
1380 Southwest Import Drive, Gatlin Commons, Port St. Lucie, FLSpace Type- Office
For Lease- $25.00/SF/YR
3 spaces available / 801 - 2,247 SF -
8241 Business Park Dr, River Park, Port Saint Lucie, FLSpace Type- Industrial
For Lease- $18.00/SF/MO
1 space available / 2,100 SF -
567 NW Lake Whitney Place, St. Lucie West, Port St. Lucie, FL -
544 NW University Boulevard Unit 103, St. Lucie West, Port St. Lucie, FLProperty Type- Office
For Sale- $275,000
Built in 2006 / Property size 1,056 SF -
1801 Southeast Hillmoor Drive-Unit A-107, Downtown Port St. Lucie, Port St. Lucie, FLSpace Type- Office
For Lease- $28.00/SF/YR
1 space available / 1,530 SF -
12051 SW Tom Mackie Blvd, Southern Grove, Port St. Lucie, FL -
2095 NW Commerce Lakes Dr, Reserve Commerce Park, Port Saint Lucie, FLProperty Type- Industrial
For Sale- $6,400,000
Built in 2026 / Property size 23,654 SF -
7121 S US Highway 1, River Park, Port Saint Lucie, FLSpace Type- Retail
For Lease- $12.00 - $17.00/SF/YR
4 spaces available / 6,480 - 21,126 SF -
10570 S US Highway 1, Downtown Port St. Lucie, Port Saint Lucie, FLSpace Type- Office
For Lease- $21.00/SF/YR
1 space available / 1,295 SF -
11325 Southwest Discovery Way, Southern Grove, Port St. Lucie, FL -
7630 South U.S. Highway 1, Spanish Lakes, Port St. Lucie, FLSpace Type- Retail
For Lease- $23.00 - $24.00/SF/YR
4 spaces available / 928 - 1,849 SF -
9520 S U.S. Hwy 1, Downtown Port St. Lucie, Port St. Lucie, FLProperty Type- Retail
For Sale- $2,700,000
Built in 1984 / Property size 2,817 SF -
870 St. Lucie W. Boulevard, Lake Forest Pointe, Port St. Lucie, FLSpace Type- Retail
For Lease- $45.00/SF/YR
1 space available / 3,437 SF -
145 NW Central Park Plz, Port Saint Lucie, FL 34986-2482, St. Lucie West, Port Saint Lucie, FLSpace Type- Office
For Lease- $1,350.00 - $4,277.50/MO
2 spaces available / 432 - 1,711 SF -
872 SE Becker Road, Tesoro, Port Saint Lucie, FLSpace Type- Retail
For Lease- $25.00/SF/YR
1 space available / 1,125 SF -
7630 S US Highway 1, Spanish Lakes, Port St. Lucie, FLSpace Type- Retail
For Lease- $23.00/SF/YR
4 spaces available / 928 - 1,849 SF -
266 NW Peacock Blvd Unit 204 -205, St. Lucie West, FLProperty Type- Office
For Sale- $950,000
Built in 2007 / Property size 4,324 SF -
1060 Southwest Bayshore Boulevard, River Park, Port St. Lucie, FLProperty Type- Retail
For Sale- $255,000
Built in 1998 / Property size 800 SF -
2095 NW Commerce Lakes Dr, Reserve Commerce Park, Port Saint Lucie, FLSpace Type- Flex Space
For Lease- $17.50 - $21.50/SF/YR
2 spaces available / 11,827 SF -
870 St. Lucie W Blvd, Lake Forest Pointe, Port St. Lucie, FLSpace Type
- Health Care
For Lease- $45.00/SF/YR
1 space available / 3,437 SF -
2400 SE Leithgow St, Eastport St. Lucie, Port St. Lucie, FLProperty Type- VacantLand
For Sale- $2,200,000
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673 NW Enterprise Dr, St. Lucie West, Port St. Lucie, FL -
751 NW Airoso Blvd, River Park, Port Saint Lucie, FL -
525 NW Lake Whitney Place, St. Lucie West, Port St. Lucie, FLSpace Type- Office
For Lease- $21.00/SF/YR
2 spaces available / 1,133 SF -
2100 SE Hillmoor Drive Unit 204A, Eastlake Village, Port St. Lucie, FLSpace Type- Office
For Lease- $29.20/SF/YR
1 space available / 940 SF -
NW Lake Whitney Place, St. Lucie West, Port St. Lucie, FLProperty Type- Office
For Sale- Call Broker
Built in 2015 / Property size 165,722 SF -
1285 SW Del Rio Blvd, Oak Hammock, Port St. Lucie, FLProperty Type- Retail
For Sale- $95,000
Built in 2007 / Property size 1,100 SF -
Crosstown Pkwy, Southern Grove, Port St. Lucie, FL -
460-466 SW Port St Lucie Blvd, Oak Hammock, Port Saint Lucie, FLSpace Type- Retail
For Lease- $14.00 - $29.00/SF/YR
3 spaces available / 654 - 1,739 SF -
1857 SE Port St Lucie Blvd, Morningside, Port St. Lucie, FLSpace Type- Office
For Lease- $2.10/SF/MO
1 space available / 1,058 SF -
761 E Prima Vista Blvd, River Park, Port St. Lucie, FLSpace Type- Office
For Lease- $35.50/SF/YR
1 space available / 1,425 SF -
375 SW Becker Rd, Paar, Port Saint Lucie, FLProperty Type- VacantLand
For Sale- Subject To Offer
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6450 US Highway 1, Oleander Pines, Port St Lucie, FLProperty Type- VacantLand
For Sale- $599,000
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870-910 SW St. Lucie West Blvd, Westbrook Isles, Port St. Lucie, FL -
1260 SE Industrial Blvd, Port St. Lucie Industrial Park, Port Saint Lucie, FLSpace Type- Industrial
For Lease- $1,450.00/MO
1 space available / 1,000 SF -
302 SW Tulip Boulevard, Windmill Point, Port St. Lucie, FLProperty Type- Retail
For Sale- $7,000,000
Property size 4,840 SF -
TBD SW California Blvd, SLW Country Club Estates, Port St. Lucie, FLProperty Type- VacantLand
For Sale- $1,150,000
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870-910 SW St. Lucie Blvd., Lake Forest Pointe, PSL, FLSpace Type- Retail
For Lease- $45.00/SF/YR
1 space available / 2,496 SF -
300 NW Bethany Drive # 320, St. Lucie West, Port St. Lucie, FLSpace Type- Office
For Lease- $18.00/SF/YR
1 space available / 2,000 SF -
8443 S US 1, River Park, Port St. Lucie, FLSpace Type- Retail
For Lease- $15.75/SF/YR
1 space available / 2,500 SF -
Tuckpoint Business Park - 660-664 NW Enterprise Dr, St. Lucie West, Port St. Lucie, FL -
6632 S US Highway 1, Spanish Lakes, Port St. Lucie, FLSpace Type- Retail
For Lease- $25.00/SF/YR
1 space available / 1,255 SF -
7444 S. Federal Highway, Spanish Lakes, Port Saint Lucie, FLSpace Type- Office
For Lease- $26.40/SF/YR
1 space available / 1,000 SF -
6901 - 6945 NW LTC Parkway, Torino, Port Saint Lucie, FLSpace Type- Industrial
For Lease- $16.00/SF/YR
2 spaces available / 2,225 - 4,344 SF