CURE.

345 Park Avenue South, New York, NY 10010

Property Information

  • For Lease Contact for pricing
  • Property Type Office - Life Sciences
  • Property Size 309,000 SF
  • Lot Size 0.48 Acre
  • Property Tenancy Multi-Tenant
  • Building Class A
  • Year Built 1912
  • Date Updated May 7, 2026

Description

CURE. is a Class A office building totaling 309,000 square feet on a 0.48-acre lot at 345 Park Avenue South. Built in 1912, the property showcases timeless architecture and sits in a prime location within Manhattan's NoMad neighborhood. The building is surrounded by top-tier amenities, including fine dining options, boutique hotels, and cultural landmarks, making it an ideal setting for companies seeking an exceptional business environment.

Nestled in the vibrant NoMad district, the property is within walking distance of multiple subway stations, including 28th Street and Union Square. Nearby conveniences include acclaimed restaurants like Upland and Park Avenue Summer, both just steps away, as well as hotels like Hotel Giraffe and Park South Hotel, all within approximately 0.1 miles. Iconic attractions such as Madison Square Park and Broadway are also close by, contributing to the area's dynamic appeal for tenants and visitors alike.

3 Spaces Available

5th Floor

Space Type

Life Sciences

Lease Rate

Contact for pricing

Total Space

11,596 SF

Floor

5

Divisible Space

11,596 - 11,596 SF

Available Date

Immediate

Renewal Option

Yes

Sublease

No

Build Type

Shell

Partial 5th floor measures 11,596 RSF and is available in warm lab ready shell condition. Owner occupied Life Science Ecosystem that has recently completed a full building renovation inclusive of all base building infrastructure to support wet lab users. The available space are able to accommodate both office and life science users. Lab spaces will be delivered in lab-ready shell condition. For further information please visit

6th Floor

Space Type

Life Sciences

Lease Rate

Contact for pricing

Total Space

11,588 SF

Floor

6

Divisible Space

11,588 - 11,588 SF

Available Date

Immediate

Renewal Option

Yes

Sublease

No

Build Type

Shell

Owner occupied Life Science Ecosystem that has recently completed a full building renovation inclusive of all base building infrastructure to support wet lab users. The available spaces are able to accommodate both office and life science users. Lab spaces will be delivered in lab-ready shell condition.

7th Floor

Space Type

Life Sciences

Lease Rate

Contact for pricing

Total Space

27,500 SF

Floor

7

Divisible Space

27,500 - 27,500 SF

Available Date

Immediate

Renewal Option

Yes

Sublease

No

Building has 4 side of light with expansive views north and south over Park Avenue South. Life infrastructure spec sheet is available upon request.

Contacts

Paul J. Amrich

CBRE

Neil V. King III

CBRE

Matthew Dichter

CBRE

Location

Located at 345 Park Avenue South, New York, NY 10010, this property is part of the NoMad neighborhood and Manhattan market.

Contact CURE.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.