Port St. Lucie, FL Commercial Real Estate for Lease and Sale
Explore 100 listing(s) of commercial real estate in Port St. Lucie, FL to find the best space for your business.
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1901 SW Biltmore St, Thornhill, Port Saint Lucie, FLSpace Type- Industrial
For Lease- $1,000.00/MO
1 space available / 1,000 SF -
584 Northwest University Boulevard, St. Lucie West, Port St. Lucie, FLSpace Type- Office
For Lease- $27.00/SF/YR
1 space available / 4,200 SF -
130 Southeast Entrada Avenue, River Park, Port St. Lucie, FLProperty Type- Retail
For Sale- $1,300,000
Built in 1980 / Property size 3,044 SF -
302 SW Tulip Boulevard, Windmill Point, Port St. Lucie, FLProperty Type- Retail
For Sale- $7,000,000
Property size 4,840 SF -

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1060 Southwest Bayshore Boulevard, River Park, Port St. Lucie, FLProperty Type- Retail
For Sale- $255,000
Built in 1998 / Property size 800 SF -
6940 Heritage Dr, Oleander Pines, Port Saint Lucie, FLProperty Type- Industrial
For Sale- $650,000
Built in 2002 / Property size 3,213 SF -
6450 US Highway 1, Oleander Pines, Port St Lucie, FLProperty Type- VacantLand
For Sale- $599,000
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544 NW University Boulevard Unit 103, St. Lucie West, Port St. Lucie, FLProperty Type- Office
For Sale- $275,000
Built in 2006 / Property size 1,056 SF -
585 NW Lake Whitney Place, St. Lucie West, Port St. Lucie, FLSpace Type- Office
For Lease- $25.00/SF/YR
1 space available / 6,619 SF -
SW Port St Lucie Blvd, Oak Hammock, Port Saint Lucie, FLSpace Type- Retail
For Lease- $22.00 - $31.00/SF/YR
2 spaces available / 1,165 - 2,124 SF -
870 St. Lucie W Blvd, Lake Forest Pointe, Port St. Lucie, FL -
Tuckpoint Business Park - 660-664 NW Enterprise Dr, St. Lucie West, Port St. Lucie, FL -
300 NW Bethany Drive # 320, St. Lucie West, Port St. Lucie, FLSpace Type- Office
For Lease- $18.00/SF/YR
1 space available / 2,000 SF -
584 NW University Blvd Suite 350 584 Northwest University Boulevard, Port St. Lucie, FLProsperity Business Suites
Prosperity Business Suites -
1459 SE Village Green Dr # A12, Port St. Lucie Industrial Park, Port Saint Lucie, FLProperty Type- Industrial
For Sale- $198,000
Built in 1984 / Property size 814 SF -
7630 S US Highway 1, Spanish Lakes, Port St. Lucie, FLSpace Type- Retail
For Lease- $23.00 - $24.00/SF/YR
4 spaces available / 928 - 1,849 SF -
1901 Southwest Biltmore Street, Thornhill, Port St. Lucie, FLSpace Type- Industrial
For Lease- $1,450.00/MO
1 space available / 1,000 SF -
1401-1421 Southwest Biltmore Street, River Park, Port St. Lucie, FLSpace Type- Industrial
For Lease- $1,300.00/SF/MO
2 spaces available / 1,000 SF -
NW Lake Whitney Place, St. Lucie West, Port St. Lucie, FL -
751 NW Airoso Blvd, River Park, Port Saint Lucie, FL -
1801 Southeast Hillmoor Drive-Unit A-107, Downtown Port St. Lucie, Port St. Lucie, FLSpace Type- Office
For Lease- $28.00/SF/YR
1 space available / 1,530 SF -
201 SW Port St Lucie Blvd, Thornhill, Port Saint Lucie, FLSpace Type- Office
For Lease- $595.00/MO
1 space available / 100 SF -
10570 S US Highway 1, Downtown Port St. Lucie, Port Saint Lucie, FLSpace Type- Office
For Lease- $21.00/SF/YR
1 space available / 1,295 SF -
8443 S US 1, River Park, Port St. Lucie, FLSpace Type- Retail
For Lease- $15.75/SF/YR
1 space available / 2,500 SF -
10111 U.S. 1, Morningside, Port St. Lucie, FLSpace Type- Retail
For Lease- $175,000.00/YR
1 space available / 4,352 SF -
460-466 SW Port St Lucie Blvd, Oak Hammock, Port Saint Lucie, FLSpace Type- Retail
For Lease- $14.00 - $29.00/SF/YR
3 spaces available / 654 - 1,739 SF -
1260 SE Industrial Blvd, Port St. Lucie Industrial Park, Port Saint Lucie, FLProperty Type- Industrial
For Sale- $2,200,000
Built in 2003 / Property size 10,000 SF -
10460 Southwest Fellowship Way, Tradition, Port St. Lucie, FLProperty Type- VacantLand
For Sale- Subject To Offer
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870-910 St Lucie W Blvd, Lake Forest Pointe, Port St. Lucie, FLSpace Type
- Retail
For Lease- $45.00/SF/YR
1 space available / 2,496 SF -
567 NW Lake Whitney Place, St. Lucie West, Port St. Lucie, FL -
6901 - 6945 NW LTC Parkway, Torino, Port Saint Lucie, FLSpace Type- Industrial
For Lease- $16.00/SF/YR
2 spaces available / 2,225 SF -
1380 Southwest Import Drive, Gatlin Commons, Port St. Lucie, FL -
870 St. Lucie W Blvd, Lake Forest Pointe, Port St. Lucie, FLSpace Type
- Health Care, Retail
For Lease- $30.00 - $45.00/SF/YR
3 spaces available / 1,965 - 3,437 SF -
10460 Southwest Fellowship Way, Tradition, Port St. Lucie, FL -
2095 NW Commerce Lakes Dr, Reserve Commerce Park, Port Saint Lucie, FLSpace Type- Flex Space
For Lease- $19.50/SF/YR
2 spaces available / 11,827 SF -
2400 SE Leithgow St, Eastport St. Lucie, Port St. Lucie, FLProperty Type- VacantLand
For Sale- $2,350,000
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Crosstown Pkwy, Southern Grove, Port St. Lucie, FL -
1309 SW Gatlin Boulevard, Oak Hammock, Port St. Lucie, FL -
2200 Southwest Del Rio Boulevard, Oak Hammock, Port St. Lucie, FLProperty Type- Unassigned
For Sale- $7,900,000
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7041 & 7043 S US Highway 1, River Park, Port St. Lucie, FLSpace Type- Office
For Lease- $23.00/SF/YR
2 spaces available / 2,242 - 2,979 SF -
266 NW Peacock Blvd Unit 204 -205, St. Lucie West, FLProperty Type- Office
For Sale- $950,000
Built in 2007 / Property size 4,324 SF -
375 SW Becker Rd, Paar, Port Saint Lucie, FLProperty Type- VacantLand
For Sale- Subject To Offer
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1260 SE Industrial Blvd, Port St. Lucie Industrial Park, Port Saint Lucie, FLSpace Type- Industrial
For Lease- $1,450.00/SF/MO
1 space available / 1,000 SF -
7630 South U.S. Highway 1, Spanish Lakes, Port St. Lucie, FLSpace Type- Retail
For Lease- $23.00 - $24.00/SF/MO
4 spaces available / 928 - 1,849 SF -
2400 Southeast Leithgow Street, Eastport St. Lucie, Port St. Lucie, FL -
TBD SW California Blvd, SLW Country Club Estates, Port St. Lucie, FLProperty Type- VacantLand
For Sale- $1,150,000
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870-910 SW St. Lucie West Blvd, Westbrook Isles, Port St. Lucie, FL -
145 NW Central Park Plz, Port Saint Lucie, FL 34986-2482, St. Lucie West, Port Saint Lucie, FLSpace Type- Office
For Lease- $1,350.00 - $4,277.50/MO
2 spaces available / 432 - 1,711 SF -
Hegener Dr, Southern Grove, Port St. Lucie, FL -
870-910 SW St. Lucie Blvd., Lake Forest Pointe, PSL, FLSpace Type- Retail
For Lease- $45.00/SF/YR
1 space available / 2,496 SF -
7121 S US Highway 1, River Park, Port Saint Lucie, FLSpace Type- Retail
For Lease- $12.00 - $14.00/SF/YR
3 spaces available / 8,300 - 21,126 SF -
8241 Business Park Dr, River Park, Port Saint Lucie, FLSpace Type- Industrial
For Lease- $18.00/SF/MO
1 space available / 2,100 SF -
NW Lake Whitney Place, St. Lucie West, Port St. Lucie, FLProperty Type- Office
For Sale- Call Agent for OM
Built in 2015 / Property size 165,722 SF