Cape Girardeau, MO Commercial Real Estate for Lease and Sale

Explore 64 listing(s) of commercial real estate in Cape Girardeau, MO to find the best space for your business.

CRE Market FAQs

4,500 SF Lease Space in Historic Cape

731 Broadway St, Cape Girardeau, MO
Space Type

Retail
For Lease

$3,000.00/MO
1 space available / 4,500 SF
View Details
26.9 Acres of Prime Development Property

Route K, Cape Girardeau, MO
Property Type

VacantLand
For Sale

$2,100,000
View Details
1,600 SF Office Suite Available For Lease

760 S Kingshighway, Suite M, Cape Girardeau, MO
Space Type

Office
For Lease

$1,470.00/MO
1 space available / 1,600 SF
View Details
6,850 SF of Office & Warehouse Type Space

760 S Kingshighway, Suite H, Cape Girardeau, MO
Space Type

Industrial
For Lease

$4,500.00/MO
1 space available / 6,850 SF
View Details
Center Pointe Commons

151 S Mount Auburn Rd, Cape Girardeau, MO
Space Type

Office
For Lease Contact for pricing

1 space available / 1,250 SF
View Details
5.34 Acres of Prime Development Property

423 S Silver Springs Rd, Cape Girardeau, MO
Property Type

VacantLand
For Sale

$1,700,000
View Details
Lambert Plaza

155 Siemers Drive, Cape Girardeau, MO
Space Type

Retail
For Lease Contact for pricing

2 spaces available / 4,850 - 9,400 SF
View Details
2,880 SF of Office or Service Space

760 South Kingshighway, Suite K, Cape Girardeau, MO
Space Type

Office
For Lease

$3,120.00/MO
1 space available / 2,280 SF
View Details
Codefi - 338 Broadway Street

338 Broadway Street 6th Floor #601, Cape Girardeau, MO
Space Type

Private Offices
For Lease

From $300/month
View Details
West Park Mall - Outlot 4

3049 William Street, Cape Girardeau, MO
Property Type

VacantLand
For Sale Contact for pricing

Property size 1 Acre
View Details
3,500 SF Commercial Building

500 N Kingshighway St, Cape Girardeau, MO
Space Type

Retail
For Lease

$3,650.00/MO
1 space available / 3,500 SF
View Details

Frequently Asked Questions

Here is a rundown of the primary commercial real estate property types currently available in Cape Girardeau:
- Office Space: The market includes 178,106 square feet of office spaces in addition to 20 coworking locations.
- Retail Space: Between malls, restaurants and stores, Cape Girardeau is home to 720,143 square feet of available retail space.
- Industrial Space: Warehouses, distribution centers, manufacturing facilities and other industrial types total 59,853 square feet of available space in Cape Girardeau.
The average rent for commercial real estate in Cape Girardeau is $10.77 per square foot. However, specific rates may vary widely by property type, class and quality. The cheapest commercial space in Cape Girardeau costs $5.17, while the city’s premium locations ask up to $18.
Here is a breakdown of the average size of different property classes (also known as asset class or property type):
- Class A/A+ properties have an average size of 17,785 square feet.
- Class B properties are sized 7,430 square feet, on average.
- Class C properties span an average of 2,566 square feet.
CommercialCafe’s CRE offering in Cape Girardeau is enabled by a network of 6 active brokers from 3 different firms, ensuring a wide variety of listings. Working with an experienced professional can make a real difference. Learn more about the benefits of working with a broker.

To get in touch with a broker, use the "Contact Property" button on this search page or fill in the contact form provided on each individual property’s listing page.
The profitability of a commercial real estate investment depends on a multitude of factors working together. These factors include the quality of the asset itself, local market conditions, the state of the local economy and the demand for that particular type of commercial property, to name a few.

Asking rents in the city can be as high as $18 per square foot. In particular, the property type commanding the highest lease rates in Cape Girardeau is Office space.
The average size of a commercial property here stands at 50,530. However, different asset classes and zoning laws will result in vastly different property sizes. Here is a breakdown of the average size of different commercial asset classes in Cape Girardeau:
Office properties:
- Average size: 11,132 square feet.
- Largest property: 301 S. Broadview Street - 15,100 SF Office Space (15,100 square feet).
Retail properties:
- Average size: 34,293 square feet.
- Largest property: Former Trees & Trends (46,000 square feet).
Industrial properties:
- Average size: 11,971 square feet.

Cape Girardeau, MO Commercial Space Listings

Commercial Space for Lease - Breakdown

The 40 listings for commercial real estate currently available for rent in Cape Girardeau add up to 418,570 square feet across various property types. Here's a breakdown of the available space by category:

Property Type	Count of Listings	Total Sq. Ft.
Office	12	63,913
Retail	21	262,443
Industrial	5	41,685
Other	2	50,529

Office properties:

The market has 12 active office listings, encompassing 63,913 square feet.
Cape Girardeau office spaces currently listed on CommercialCafe represent 30% of the total commercial real estate market in Cape Girardeau, compared to an average of 39% across all markets tracked by CommercialCafe.

Retail Space:

There are 21 retail listings available, adding up to a total of 262,443 square feet.
Retail spaces account for approximately 52% of the local commercial market, while the average share taken up by retail in all U.S. markets is 34%.

Industrial Space:

The industrial market in Cape Girardeau offers 5 listings, amounting to 41,685 available square feet.
Industrial spaces, including warehouses and manufacturing sites, make up about 12% of the total commercial space available in the market, compared to a nationwide average of 25%.

The data presented in this section was last updated as of September 10, 2026

Commercial Space for Sale - Breakdown

There are currently 25 properties listed for sale in the Cape Girardeau market, adding up to 50,036 square feet of space available for purchase. Here is a breakdown of the commercial space for sale listed locally:

4 office properties
2 retail properties
1 industrial property

The data presented in this section was last updated as of September 10, 2026

Property Type	Count of Listings	Total Sq. Ft.
Office	4	31,227
Retail	2	8,405
Industrial	1	10,400
Other	18	4

Cape Girardeau, MO Commercial Real Estate for Lease and Sale

4,500 SF Lease Space in Historic Cape

26.9 Acres of Prime Development Property

1,600 SF Office Suite Available For Lease

6,850 SF of Office & Warehouse Type Space

Center Pointe Commons

5.34 Acres of Prime Development Property

Lambert Plaza

2,880 SF of Office or Service Space

Codefi - 338 Broadway Street

West Park Mall - Outlot 4

3,500 SF Commercial Building

Frequently Asked Questions

Cape Girardeau, MO Commercial Space Listings

Commercial Space for Lease - Breakdown

Commercial Space for Sale - Breakdown

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