Saint Louis, MO Commercial Real Estate for Lease and Sale

Explore 382 listing(s) of commercial real estate in Saint Louis, MO to find the best space for your business.

1320 Pierce Avenue

1320 Pierce Avenue, Cheltenham, St. Louis, MO
Property Type

VacantLand
For Sale

$49,000
Property size 0.13 Acre
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1311 S 39th Street

1311 S 39th Street, Botanical Heights, St. Louis, MO
Property Type

Industrial
For Sale

$5,250,000
Property size 210,000 SF
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3952 Clayton Ave st Louis

3952 Clayton Ave st Louis, Forest Park South East, St. Louis, MO
Space Type

Industrial
For Lease

$8.50/SF/YR
1 space available / 16,370 SF
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4421 Ridgewood Avenue

4421 Ridgewood Avenue, Bevo Mill, St. Louis, MO
Space Type

Industrial
For Lease

$6.00/SF/YR
1 space available / 25,900 SF
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1320, 1326, 1330 Hughes Place

1330 Hughes Place, Cheltenham, St. Louis, MO
Property Type

Industrial
For Sale

$215,000
Property size 950 SF
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The Dreamer's Loft - 2710 Lafayette Avenue

2710 Lafayette Avenue, St. Louis, MO
Space Type

Desks
For Lease

From $20/day
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5737-5743 W Park Ave

5737-5743 W Park Ave, Cheltenham, Saint Louis, MO
Space Type

Industrial
For Lease

$8.00/SF/YR
1 space available / 4,667 SF
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1053-1057 South Vandeventer Ave

1053-1057 South Vandeventer Ave, Forest Park South East, St. Louis, MO
Property Type

Multi-Family
For Sale

$995,000
Property size 5,708 SF
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3601 Blair Avenue

3601 Blair Avenue, Hyde Park, St Louis, MO
Property Type

Industrial
For Sale

$295,000
Property size 7,700 SF
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5137 Southwest Avenue

5137 Southwest Ave, The Hill, Saint Louis, MO
Property Type

Office
For Sale

$595,000
Property size 30,252 SF
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3201 Washington Avenue

3201 Washington Avenue, Covenant Blu - Grand Center, St. Louis, MO
Property Type

Office
For Sale

$625,000
Property size 5,885 SF
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Frequently Asked Questions

Here is a rundown of the primary commercial real estate property types currently available in Saint Louis:
- Office Space: The market includes 8,833,259 square feet of office spaces in addition to 322 coworking locations.
- Retail Space: Between malls, restaurants and stores, Saint Louis is home to 3,045,524 square feet of available retail space.
- Industrial Space: Warehouses, distribution centers, manufacturing facilities and other industrial types total 4,508,599 square feet of available space in Saint Louis.
The average rent for commercial real estate in Saint Louis is $15.87 per square foot. However, specific rates may vary widely by property type, class and quality. The cheapest commercial space in Saint Louis costs $1.24, while the city’s premium locations ask up to $47.71.
Here is a breakdown of the average size of different property classes (also known as asset class or property type):
- Class A/A+ properties have an average size of 190,355 square feet.
- Class B properties are sized 106,478 square feet, on average.
- Class C properties span an average of 26,637 square feet.
The best area for commercial real estate in Saint Louis will depend greatly on your needs. The neighborhood with the largest overall number of commercial listings is Downtown Saint Louis, home to no fewer than 256 listings for space of all types. If you're looking for office space, Downtown Saint Louis has the highest concentration of office listings at 224.

Meanwhile, North Riverfront has the highest number of industrial availabilities (7), while Downtown Saint Louis boasts the largest number of retail listings in the city (29).
CommercialCafe’s CRE offering in Saint Louis is enabled by a network of 166 active brokers from 71 different firms, ensuring a wide variety of listings. Working with an experienced professional can make a real difference. Learn more about the benefits of working with a broker.

To get in touch with a broker, use the "Contact Property" button on this search page or fill in the contact form provided on each individual property’s listing page.
The profitability of a commercial real estate investment depends on a multitude of factors working together. These factors include the quality of the asset itself, local market conditions, the state of the local economy and the demand for that particular type of commercial property, to name a few.

Asking rents in the city can be as high as $47.71 per square foot. In particular, the property type commanding the highest lease rates in Saint Louis is Office space.
The average size of a commercial property here stands at 3,208,918. However, different asset classes and zoning laws will result in vastly different property sizes. Here is a breakdown of the average size of different commercial asset classes in Saint Louis:
Office properties:
- Average size: 93,971 square feet.
- Largest property: Space Available (392,986 square feet).
Retail properties:
- Average size: 33,840 square feet.
- Largest property: 4930 Christy Blvd #3B (39,165 square feet).
Industrial properties:
- Average size: 77,735 square feet.
- Largest property: 520 Carondelet Commons Blvd (160,000 square feet).

Saint Louis, MO Commercial Space Listings

Commercial Space for Lease - Breakdown

The 229 listings for commercial real estate currently available for rent in Saint Louis add up to 8,713,852 square feet across various property types. Here's a breakdown of the available space by category:

Property Type	Count of Listings	Total Sq. Ft.
Office	91	3,502,814
Retail	81	607,817
Industrial	30	1,394,304
Other	27	3,208,917

Office properties:

The market has 91 active office listings, encompassing 3,502,814 square feet.
Saint Louis office spaces currently listed on CommercialCafe represent 39% of the total commercial real estate market in Saint Louis, compared to an average of 39% across all markets tracked by CommercialCafe.

Retail Space:

There are 81 retail listings available, adding up to a total of 607,817 square feet.
Retail spaces account for approximately 35% of the local commercial market, while the average share taken up by retail in all U.S. markets is 34%.

Industrial Space:

The industrial market in Saint Louis offers 30 listings, amounting to 1,394,304 available square feet.
Industrial spaces, including warehouses and manufacturing sites, make up about 13% of the total commercial space available in the market, compared to a nationwide average of 25%.

The data presented in this section was last updated as of November 04, 2026

Commercial Space for Sale - Breakdown

There are currently 149 properties listed for sale in the Saint Louis market, adding up to 2,958,298 square feet of space available for purchase. Here is a breakdown of the commercial space for sale listed locally:

28 office properties
25 retail properties
31 industrial properties

The data presented in this section was last updated as of November 04, 2026

Property Type	Count of Listings	Total Sq. Ft.
Office	28	713,586
Retail	25	168,314
Industrial	31	1,308,790
Other	65	767,608

Saint Louis, MO Commercial Real Estate for Lease and Sale

1320 Pierce Avenue

1311 S 39th Street

3952 Clayton Ave st Louis

4421 Ridgewood Avenue

1320, 1326, 1330 Hughes Place

The Dreamer's Loft - 2710 Lafayette Avenue

5737-5743 W Park Ave

1053-1057 South Vandeventer Ave

3601 Blair Avenue

5137 Southwest Avenue

3201 Washington Avenue

Frequently Asked Questions

Saint Louis, MO Commercial Space Listings

Commercial Space for Lease - Breakdown

Commercial Space for Sale - Breakdown

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