The American Twine Building - Sublease

222 Third Street, Cambridge, MA 02142

Property Information

  • For Lease Contact for pricing
  • Property Type Office - General Office
  • Property Size 120,668 SF
  • Building Class B
  • Date Updated Jul 7, 2026

Description

The American Twine Building in the heart of Cambridge, MA. This vibrant area is home to prestigious universities, including the renowned Massachusetts Institute of Technology, and an array of tech companies, creating a hub of innovation and collaboration. Enjoy convenient access to the serene Charles River for moments of relaxation, while nearby restaurants and cafes offer an array of culinary delights. Experience the rich cultural scene with world-class museums and theaters just a short distance away. The location provides an inspiring environment for Office / Office Building tenants, with its blend of academic, technological, and cultural influences.Located in the heart of East Cambridge’s Kendall Square submarket, the American Twine Building is a historic brick and beam office building just a short walk from the Kendall Square Red Line and Lechmere Green Line MBTA stations, surrounded by new restaurant and retail offerings. Originally an industrial property, the approximately 122,000 SF building sits on a nearly two-acre site, placing tenants steps from world-class universities and a thriving ecosystem of biotech and technology companies, with close proximity to both MIT and Harvard providing access to a deep pool of elite talent. This ±1,691 SF suite offers the building’s signature character, exposed brick and beams with large windows that allow an abundance of natural light throughout. The space is ideally suited for a growing technology, professional services, or life science administrative user seeking a creative office environment with built-in flexibility and a defined term

1 Space Available

2242

Space Type

General Office

Lease Rate

Contact for pricing

Total Space

1,691 SF

Floor

2

Divisible Space

1,691 - 1,691 SF

Available Date

Immediate

Lease Type

Modified Gross

Sublease

Yes

Sublease Expiry

Sep 01, 2026

- Historic brick and beam construction with abundant natural light • Building amenities include on-site reserved parking, 24-hour security, a grab-and-go café, showers, and a shared conference room • Steps from CambridgeSide and East Cambridge’s restaurant and retail corridor • Walkable to both Kendall/MIT (Red Line) and Lechmere (Green Line) stations; approximately one mile from I-93

Contacts

Location

Located at 222 Third Street, Cambridge, MA 02142, this property is part of the East Cambridge neighborhood and Boston market.

Contact Listing Broker
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