6645 Main Street

6645 Main Street, Buffalo, NY 14221

Property Information

  • For Lease $18.00/SF/YR
  • Property Type Office - Medical Office
  • Property Size 10,500 SF
  • Lot Size 0.48 Acre
  • Date Updated May 8, 2026

Description

This medical office property at 6645 Main Street totals 10,500 square feet on a 0.48-acre lot in Buffalo. With its professional layout, it is well-suited for healthcare practitioners seeking a convenient and functional space to operate their practice. The property benefits from its proximity to nearby parking lots, enhancing accessibility for staff and patients alike.

The surrounding area offers a mix of amenities that add value for tenants and visitors. Restaurants such as Williamsville Bar and Grill, Arby's, and Salsarita's Fresh Cantina are all within walking distance, providing convenient options for meals or quick breaks. Hotels like Hawthorn Suites by Wyndham and Salvatore's Grand Hotel, just over a mile away, are ideal for accommodating visiting professionals or out-of-town patients. Additionally, educational institutions like Erie Community College North Campus, just 0.84 miles away, and multiple fuel stations, including a Tesla Supercharger approximately 0.6 miles from the property, contribute to the area's utility and convenience.

1 Space Available

Full Building

Space Type

Medical Office

Lease Rate

$18.00/SF/YR

Total Space

10,500 SF

Divisible Space

10,500 - 10,500 SF

# Of Parking Spaces

60

Available Date

Immediate

Renewal Option

Yes

Sublease

No

  • Main Street Williamsville Medical Office Space for Sale or Lease
  • 6645 Main Street is situated in densely populated Williamsville, just west of Transit Rd
  • Offering ample exam rooms, new HVAC (2023) 60+ car parks, and high visibility and accessibility for businesses or medical professionals seeking a strategic location
  • Current owner user is willing to stay in place with a new lease

Contacts

Emily Cornwell

Hanna Commercial Real Estate

Location

Contact Listing Broker
Emily Cornwell

Hanna Commercial Real Estate

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.