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South San Francisco Office Rent Price & Sales Report

Highlights

  • The average rent for office space in South San Francisco is $82.96 per square foot, 4.23% lower compared to the previous year.
  • The market’s vacancy rate stands at 26.01%, higher than the state average of California, which is 18.44%.

2025 Office Space Rent & Sales

  • $82.96 2025 Avg. Asking Rent
  • -4.23% Y-o-Y Avg. Asking Rent Change
  • 26.01% 2025 Office Vacancy Rate

What is the average asking rent price for office space in South San Francisco?

Average asking rents for office space here stand at $82.96 per square foot. The local office market recorded an average vacancy rate of 26.01% in 2025, unchanged from 26.01% in 2024.

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Browse 184 available office listings in South San Francisco and narrow down options by price, size and location.

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South San Francisco, CA Office Asking Rents by Class

What is the average office rent per square foot by property class in CA?

  • Avg. Asking Rent Class A & A+$58.81
  • Avg. Asking Rent Class B$37.82
  • Avg. Asking Rent Class C$22.26

For comparison, the average rent for Class A and A+ office space in California was $58.81 per square foot. The state-wide average for Class B space was $37.82 per square foot, and Class C office spaces averaged $22.26 per square foot.

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2025 Office Construction in South San Francisco, CA

  • South San Francisco, CA Total SF completed in 2025 330,300

How much office space was built in South San Francisco in 2025?

330,300 square feet of new office space was delivered across the market in the previous year. New construction included 1 properties, with an average new property size of 330,300 square feet.

What are the largest recent office completions in South San Francisco?

The largest recent office completion here is Kilroy Oyster Point - II at 865,000 square feet, completed in 2025. The next largest completions are Gateway of Pacific II and Genesis - North Tower.

Office building Address SF Completed
Kilroy Oyster Point - II 373 Oyster Point Blvd, 94080 865,000 2025
Vantage - Building B 490 Forbes Blvd, 94080 188,000 2024
Gateway of Pacific V - North Building 475 Eccles Avenue, 94080 160,000 2024
Gateway of Pacific V - South Building 485 Eccles Avenue, 94080 160,000 2024
Gateway of Pacific II 750 Gateway Blvd, 94080 440,000 2021
201 Haskins Way 201 Haskins Way, 94080 311,368 2021
279 East Grand Avenue 279 East Grand Avenue, 94080 211,405 2019
The Cove at Oyster Point VII 131 Oyster Point Blvd, 94080 175,830 2019
Genesis - North Tower 2 Tower Place, 94080 381,523 2018
The Cove at Oyster Point I 111 Oyster Point Blvd, 94080 115,697 2017
Data provided by Yardi Research

See reports for other markets

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  • San Francisco Office Rent Price
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Disclaimer

All information on this page is based on city-level data that includes properties equal to or larger than 25,000 square feet.
Averages were calculated based on values dated between January 1st and December 31st 2025. Construction pipeline data represented herein is valid as of January 2026.

While every effort was made to ensure the accuracy of the data presented in this report, the information is provided “as is” and neither CommercialCafe nor Yardi Research Data can guarantee that the information provided is complete.

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