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111 Office Spaces for Rent in South San Francisco, CA

  • 90 South Spruce - S San Francisco
    90 Spruce Ave, S., Orange Park, S San Francisco, CA
    For Lease
    • $25.8 - $33/SF/YR
    Property
    • Industrial
    • 36,410 SF
    Availability
    • 4 Spaces
    • 5,202 SF
    Year Built
    • 1900
    View Details
  • SPACES OYSTER POINT - San Francisco
    Coworking
    Spaces - California, South San Francisco - Oyster Point Suite 120, San Francisco, CA
    Services
    • Virtual Office
    • Open Workspace
    • Event Space
    • Meeting Room
    • Private Office
    Amenities
    View Details
  • The Gateway North Campus - 901 Gateway Blvd - South San Francisco
    901 Gateway Blvd, Gateway, South San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 110,428 SF
    Availability
    • 3 Spaces
    • 111,000 SF
    Year Built
    • 2000
    View Details
  • Oyster Point Marina Plaza II - S San Francisco
    395 Oyster Point Blvd, Oyster Point, S San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 232,733 SF
    Availability
    • 15 Spaces
    • 96,331 SF
    Year Built
    • 1986
    View Details
  • The Gateway North Campus - 951 Gateway Blvd - South San Francisco
    951 Gateway Blvd, Gateway, South San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 59,816 SF
    Availability
    • 2 Spaces
    • 39,000 SF
    Year Built
    • 2002
    View Details
  • 2400 Westborough Blvd - South San Francisco
    2400 Westborough Blvd, North Westborough, South San Francisco, CA
    For Lease
    • $2.75/SF/MO
    Property
    • Office
    • 32,214 SF
    Availability
    • 1 Space
    • 1,011 SF
    Year Built
    • 1976
    View Details
  • Gateway Commons - 651 Gateway - South San Francisco
    651 Gateway Blvd, Gateway, South San Francisco, CA
    For Lease
    • $7/SF/YR
    Property
    • Office
    • 325,216 SF
    Availability
    • 1 Space
    • 325,215 SF
    Year Built
    • 1986
    View Details
  • Gateway Crossing - 1 Corporate Drive - South San Francisco
    1 Corporate Drive, Gateway, South San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 71,479 SF
    Availability
    • 1 Space
    • 36,000 SF
    Year Built
    • 1999
    View Details
  • Britannia Pointe Grand - South San Francisco
    250 East Grand Avenue, The East Side, South San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 630,500 SF
    Availability
    • 4 Spaces
    • 154,724 SF
    Year Built
    • 1989
    View Details
  • Britannia Oyster Point I - C - South San Francisco
    1140 Veterans Blvd, Oyster Point, South San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 67,000 SF
    Availability
    • 3 Spaces
    • 69,058 SF
    Year Built
    • 2003
    View Details
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  • 701 Gateway - S San Francisco
    701 Gateway Blvd, Gateway, S San Francisco, CA
    For Lease
    • $39/SF/YR
    Property
    • Office
    • 176,036 SF
    Availability
    • 1 Space
    • 4,293 SF
    Year Built
    • 1999
    View Details
  • The Gateway Technology Center - 600 Gateway Blvd - South San Francisco
    600 Gateway Blvd, The East Side, South San Francisco, CA
    For Lease
    • $5.75/SF/MO
    Property
    • Office
    • 81,308 SF
    Availability
    • 2 Spaces
    • 14,000 SF
    Year Built
    • 1998
    View Details
  • 7000 Shoreline Court - South San Francisco
    7000 Shoreline Court, Paradise Valley, South San Francisco, CA
    For Lease
    • $84/SF/YR
    Property
    • Office
    • 136,395 SF
    Availability
    • 3 Spaces
    • 35,435 SF
    Year Built
    • 2003
    View Details
  • The Gateway Technology Center - 630 Gateway Blvd - South San Francisco
    630 Gateway Blvd, The East Side, South San Francisco, CA
    For Lease
    • $66/SF/YR
    Property
    • Office
    • 50,160 SF
    Availability
    • 1 Space
    • 61,160 SF
    Year Built
    • 2001
    View Details
  • Oyster Point Marina Plaza I - S San Francisco
    400 Oyster Point Blvd, Oyster Point, S San Francisco, CA
    For Lease
    • $45/SF/YR
    Property
    • Office
    • 231,769 SF
    Availability
    • 19 Spaces
    • 38,522 SF
    Year Built
    • 1986
    View Details
  • Gateway Commons - S San Francisco
    611 Gateway Blvd, Gateway, S San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 260,337 SF
    Availability
    • 1 Space
    • 24,512 SF
    Year Built
    • 2002
    View Details
  • SAPCES OYSTER POINT - South San Francisco
    Coworking
     
    Services
    • Virtual Office
    • Open Workspace
    • Event Space
    • Meeting Room
    • Private Office
    Amenities
    View Details
  • Genesis - South Tower - South San Francisco
    1 Tower Place, Paradise Valley, South San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 324,986 SF
    Availability
    • 1 Space
    • 14,997 SF
    Year Built
    • 2009
    View Details
  • Southline - Building 5 - South San Francisco
    NEC Tanforan Avenue & South Maple Avenue, Lindenville, South San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 319,365 SF
    Availability
    • 1 Space
    • 319,365 SF
    View Details
  • Cabot, Cabot & Forbes - S San Francisco
    434-436 Rozzi Pl, The East Side, S San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 9,810 SF
    Availability
    • 1 Space
    • 4,848 SF
    View Details
  • Southline - Building 6 - South San Francisco
    NEC Tanforan Avenue & South Maple Avenue, Lindenville, South San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 693,815 SF
    Availability
    • 1 Space
    • 693,815 SF
    View Details
  • Kilroy Oyster Point - Gravitate - San Francisco
    389 Oyster Point Blvd, Oyster Point, San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 860,000 SF
    Availability
    • 1 Space
    • 900,000 SF
    Year Built
    • 2024
    View Details
  • 192 Beacon St - South San Francisco
    192 Beacon St, San Bruno Canal, South San Francisco, CA
    For Lease
    • $2.75/SF/MO
    Property
    • Office
    • 8,000 SF
    Availability
    • 1 Space
    • 8,000 SF
    View Details
  • Gateway of Pacific III - South San Francisco
    700 Gateway Blvd, The East Side, South San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 360,000 SF
    Availability
    • 1 Space
    • 350,000 SF
    Year Built
    • 2022
    View Details
  • Southline - Building 7 - South San Francisco
    NEC Tanforan Avenue & South Maple Avenue, Lindenville, South San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 295,220 SF
    Availability
    • 1 Space
    • 295,220 SF
    View Details
  • 156 South Spruce - S San Francisco
    156 Spruce St, S., Orange Park, S San Francisco, CA
    For Lease
    • $29.4 - $33/SF/YR
    Property
    • Industrial
    • 17,614 SF
    Availability
    • 3 Spaces
    • 3,049 SF
    Year Built
    • 1900
    View Details

South San Francisco, CA Office Space Listings

There are currently 130 office listings available in South San Francisco, CA. These listings include 111 office spaces that encompass a total of 5,172,947 square feet. Available office spaces in South San Francisco, CA range in size from 667 square feet to 900,000 square feet. A total of 88 off-market office properties located in South San Francisco, CA are also available for research.

Look For Office Space Near Me

Are you still looking for the office space near you that’s perfect for your business? Browse through all available CommercialCafe listings in your area to find the right fit — the space that meets your requirements, right now and for the future. Easily compare sizes, prices, amenities and locations of office spaces for rent near me. Expand your search beyond your neighborhood and ZIP code and search our listings in any city or state to find the best fit for your needs, wherever you are in the U.S. The perfect office space for rent near South San Francisco, CA is only one search away.

South San Francisco, CA Office Inventory Breakdown

Office Spaces

Total: 22,576,291 SF

Data provided by Yardi Matrix, properties over 50k SF, includes office with retail
By square footage range:
50k to 100k SqFt 2,051,746 SqFt 9.09% of total office
100k to 500k SqFt 12,948,054 SqFt 57.35% of total office
500k to 1M SqFt 6,168,130 SqFt 27.32% of total office
> 1M SqFt 1,408,361 SqFt 6.24% of total office
By class:
Class A 12,938,551 SqFt 57.31% of total office
Class B 3,979,148 SqFt 17.63% of total office
In 2022 the South San Francisco, CA office market encompassed 22,576,291 square feet of space. Of these, 6,168,130 square feet were office properties between 500K to 1M square feet and 2,051,746 square feet were buildings between 50k to 100k.

Class A office space makes up a 57.31% share of South San Francisco, CA office inventory, while Class B office assets represent roughly 17.63%.

Frequently Asked Questions

How much does office space cost in South San Francisco, CA?

The average office rental rate in South San Francisco, CA is $59.72 per square foot. Asking prices vary based on the property’s location, overall rating, amenities, proximity to restaurants, cafes and entertainment venues, as well as public transport, airports and highways. Check South San Francisco Office Market Trends for more stats.

What is the size of available office spaces in South San Francisco, CA?

The South San Francisco, CA office market can accommodate various businesses, sporting a range of office space availabilities. The average size of office space availabilities is 450,334 square feet. If you’re just starting out as a company or as an entrepreneur, the smallest available office space in South San Francisco, CA is 667 square feet, while the maximum rentable space on the market now is 900,000 square feet.

How do I get office space in South San Francisco, CA?

Start your search for office space in South San Francisco, CA by using our filters that allow you to find the best space for your business needs. Filter listings by location, property size, available space or lease rate. Property pages will offer details about an office building’s rating, year built, availabilities, price per square foot and more. After drawing up a shortlist, make sure you contact the listed broker(s) to schedule a viewing and begin the negotiation process for your lease contract.

How many office listings are available in South San Francisco, CA?

There are 130 office listings on the South San Francisco, CA market. See all available office spaces for rent.

Where to rent an office space in South San Francisco, CA?

Popular South San Francisco neighbourhoods with available office spaces include The East Side, Oyster Point and Gateway.

What other property types are available for lease in South San Francisco, CA?

In addition to traditional office spaces, commercial real estate listings on our platform also include coworking & shared office space options, retail spaces, industrial buildings, warehouses, distribution facilities, and more.