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85 Office Spaces for Rent in South San Francisco, CA

  • 701 Gateway - S San Francisco
    701 Gateway Blvd, Gateway, S San Francisco, CA 94080
    For Lease $39 - $47.4/Sqft/Year
    Property
    • Office
    Availability
    • 2 Spaces
    • 14,501 Sqft
  • The Gateway Technology Center - 600 Gateway Blvd - South San Francisco
    600 Gateway Blvd, The East Side, South San Francisco, CA 94080
    For Lease $66/Sqft/Year
    Property
    • Office
    Availability
    • 1 Space
    • 50,400 Sqft
  • The Gateway Technology Center - 650 Gateway Blvd - South San Francisco
    650 Gateway Blvd, The East Side, South San Francisco, CA 94080
    For Lease $63/Sqft/Year
    Property
    • Office
    Availability
    • 1 Space
    • 50,400 Sqft
  • 90 South Spruce - S San Francisco
    90 Spruce Ave, S., Orange Park, S San Francisco, CA 94080
    For Lease $25.8 - $33/Sqft/Year
    Property
    • Industrial
    Availability
    • 4 Spaces
    • 5,202 Sqft
  • 220 South Spruce Avenue - South San Francisco
    220 South Spruce Avenue, Orange Park, South San Francisco, CA 94080
    For Lease $28.2/Sqft/Year
    Property
    • Office
    Availability
    • 2 Spaces
    • 4,870 Sqft
  • Gateway Commons - S San Francisco
    611 Gateway Blvd, Gateway, S San Francisco, CA 94080
    For Lease $45/Sqft/Year
    Property
    • Office
    Availability
    • 4 Spaces
    • 65,943 Sqft
  • Oyster Point Marina Plaza I - S San Francisco
    400 Oyster Point Blvd, Oyster Point, S San Francisco, CA 94080
    For Lease $42/Sqft/Year
    Property
    • Office
    Availability
    • 14 Spaces
    • 21,712 Sqft
  • 2400 Westborough Blvd - South San Francisco
    2400 Westborough Blvd, North Westborough, South San Francisco, CA 94080
    For Lease $33/Sqft/Year
    Property
    • Office
    Availability
    • 1 Space
    • 1,011 Sqft
  • Gateway Commons - S San Francisco
    651 Gateway Blvd, Gateway, S San Francisco, CA 94080
    For Lease $45/Sqft/Year
    Property
    • Office
    Availability
    • 5 Spaces
    • 92,660 Sqft
  • Gateway Commons - S San Francisco
    601 Gateway Blvd, Gateway, S San Francisco, CA 94080
    Contact for pricing
    Property
    • Office
    Availability
    • 9 Spaces
    • 125,023 Sqft
  • 11, 21, 31 & 61 Airport Blvd - South San Francisco
    21 Airport Blvd, Lindenville, South San Francisco, CA 94080
    For Lease $12.36 - $39/Sqft/Year
    Property
    • Office
    Availability
    • 4 Spaces
    • 3,990 Sqft
  • 100-130 Produce Avenue - South San Francisco
    100 Produce Avenue, Lindenville, South San Francisco, CA 94080
    For Lease $11.4 - $16.2/Sqft/Year
    Property
    • Office
    Availability
    • 5 Spaces
    • 9,105 Sqft
  • Oyster Point Marina Plaza II - S San Francisco
    395 Oyster Point Blvd, Oyster Point, S San Francisco, CA 94080
    Contact for pricing
    Property
    • Office
    Availability
    • 13 Spaces
    • 71,590 Sqft
  • The Gateway Technology Center - 630 Gateway Blvd - South San Francisco
    630 Gateway Blvd, The East Side, South San Francisco, CA 94080
    For Lease $66/Sqft/Year
    Property
    • Office
    Availability
    • 1 Space
    • 50,160 Sqft
  • Britannia Biotech Gateway Center II - South San Francisco
    225 Gateway Blvd, Gateway, South San Francisco, CA 94080
    Contact for pricing
    Property
    • Office
    Availability
    • 1 Space
    • 16,577 Sqft
  • Britannia Biotech Gateway Center I - 1 Corporate Drive - South San Francisco
    1 Corporate Drive, Gateway, South San Francisco, CA 94080
    Contact for pricing
    Property
    • Office
    Availability
    • 1 Space
    • 36,000 Sqft
  • 681 Gateway Blvd - South San Francisco
    681 Gateway Blvd, Gateway, South San Francisco, CA 94080
    Contact for pricing
    Property
    • Office
    Availability
    • 2 Spaces
    • 65,914 Sqft
  • Edgewater Business Park - South San Francisco
    260 Littlefield Avenue, The East Side, South San Francisco, CA 94080
    Contact for pricing
    Property
    • Office
    Availability
    • 1 Space
    • 14,943 Sqft
  • South San Francisco Business Center - South San Francisco
    800 Dubuque Avenue, Gateway, South San Francisco, CA 94080
    Contact for pricing
    Property
    • Office
    Availability
    • 1 Space
    • 5,741 Sqft
  • Britannia Pointe Grand - South San Francisco
    250 East Grand Avenue, The East Side, South San Francisco, CA 94080
    Contact for pricing
    Property
    • Office
    Availability
    • 1 Space
    • 23,000 Sqft
  • Britannia Modular Labs II - South San Francisco
    333 Allerton Avenue, The East Side, South San Francisco, CA 94080
    Contact for pricing
    Property
    • Office
    Availability
    • 2 Spaces
    • 50,910 Sqft
  • The Cove at Oyster Point III - South San Francisco
    151 Oyster Point Blvd, Oyster Point, South San Francisco, CA 94080
    Contact for pricing
    Property
    • Office
    Availability
    • 1 Space
    • 15,241 Sqft
  • Genesis - South Tower - South San Francisco
    1 Tower Place, Paradise Valley, South San Francisco, CA 94080
    Contact for pricing
    Property
    • Office
    Availability
    • 4 Spaces
    • 174,134 Sqft
  • Britannia Biotech Gateway Center I - 2 Corporate Drive - South San Francisco
    2 Corporate Drive, Gateway, South San Francisco, CA 94080
    Contact for pricing
    Property
    • Office
    Availability
    • 1 Space
    • 36,000 Sqft
  • The Cove at Oyster Point VII - South San Francisco
    131 Oyster Point Blvd, Oyster Point, South San Francisco, CA 94080
    Contact for pricing
    Property
    • Office
    Availability
    • 1 Space
    • 25,000 Sqft

South San Francisco, CA Office Space Listings

There are currently 109 office listings available in South San Francisco, CA. These listings include 85 office spaces that encompass a total of 2,161,255 square feet. Available office spaces in South San Francisco, CA range in size from 350 square feet to 900,000 square feet. A total of 80 off-market office properties located in South San Francisco, CA are also available for research.

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South San Francisco, CA Commercial Inventory Breakdown

Office Spaces

Total: 20,202,972 SF

Data provided by Yardi Matrix, properties over 50k SF, includes office with retail

By square footage range:

  • 50k to 100k SF: 2,038,982 SF / 10.09% of total office
  • 100k to 500k SF: 13,130,629 SF / 64.99% of total office
  • 500k to 1M SF: 2,555,000 SF / 12.65% of total office
  • > 1M SF: 2,478,361 SF / 12.27% of total office

By class:

  • Class A: 10,802,788 SF / 53.47% of total office
  • Class B: 3,944,380 SF / 19.52% of total office

Top 10 Largest Office Buildings

in South San Francisco

Office building Address Sqft Year built
Genentech Headquarters - Lower Main Campus 1 DNA Way, 94080 1,408,361 1970
Kilroy Oyster Point - Phase II 389 Oyster Point Blvd, 94080 1,070,000 n/a
Southline - Phase III - Building 6 NEC Tanforan Avenue & South Maple Avenue, 94080 707,975 n/a
Kilroy Oyster Point - Phase I 379 Oyster Point Blvd, 94080 656,000 2021
Britannia Pointe Grand 250 East Grand Avenue, 94080 630,500 1989
Southline - Phase I - Building 3 NEC Tanforan Avenue & South Maple Avenue, 94080 560,525 n/a
Southline - Phase II - Building 4 NEC Tanforan Avenue & South Maple Avenue, 94080 439,175 n/a
Gateway Boulevard Project - Future Offices SWC Gateway Blvd & Oyster Point Blvd, 94080 431,200 n/a
Genesis - North Tower 2 Tower Place, 94080 381,523 2018
Gateway of Pacific - Building 1000A 1000 Gateway Blvd, 94080 350,000 2021

Most Recently-Built Office Buildings

in South San Francisco

Office building Address Sqft Year built
The Merck Campus 221 East Grand Avenue, 94080 294,000 2019
279 East Grand Avenue 279 East Grand Avenue, 94080 211,405 2019
The Cove at Oyster Point VII 131 Oyster Point Blvd, 94080 175,830 2019
Britannia East Grand: Genentech Headquarters - South Campus - Building 40 500 East Grand Avenue, 94080 160,582 2019
The Cove at Oyster Point VI 161 Oyster Point Blvd, 94080 148,020 2019
Genesis - North Tower 2 Tower Place, 94080 381,523 2018
The Cove at Oyster Point I 111 Oyster Point Blvd, 94080 115,697 2017
The Cove at Oyster Point II 121 Oyster Point Blvd, 94080 102,737 2017
The Cove at Oyster Point III 151 Oyster Point Blvd, 94080 153,047 2016
The Cove at Oyster Point IV 171 Oyster Point Blvd, 94080 140,053 2016

South San Francisco Demographics

Population

  • Total Population67,294
  • Male Population(49.0 %) 33,005
  • Female Population(51.0 %) 34,289
  • Median Age40.00

Income/Financial

  • Average Household Income$120,721
  • Median Household Income$96,930
  • Median Income Under 25$93,841
  • Median Income 25-44$106,611
  • Median Income 45-64$113,412
  • Median Income Over 65$63,643