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103 Office Spaces for Rent in South San Francisco, CA

  • 405 Victory Avenue - South San Francisco
    405 Victory Avenue, Lindenville, South San Francisco, CA
    For Lease
    • $16.2 - $18.6/Sqft/Year
    Property
    • Industrial
    • 211,259 Sqft
    Availability
    • 6 Spaces
    • 129,208 Sqft
    Year Built
    • 1958
    View Details
  • 2400 Westborough Blvd - South San Francisco
    2400 Westborough Blvd, North Westborough, South San Francisco, CA
    For Lease
    • $2.75/Sqft/Month
    Property
    • Office
    • 32,214 Sqft
    Availability
    • 1 Space
    • 1,011 Sqft
    Year Built
    • 1976
    View Details
  • The Gateway Technology Center - 650 Gateway Blvd - South San Francisco
    650 Gateway Blvd, The East Side, South San Francisco, CA
    For Lease
    • $66/Sqft/Year
    Property
    • Office
    • 50,400 Sqft
    Availability
    • 1 Space
    • 50,400 Sqft
    Year Built
    • 1999
    View Details
  • Gateway Commons - S San Francisco
    611 Gateway Blvd, Gateway, S San Francisco, CA
    For Lease
    • $45/Sqft/Year
    Property
    • Office
    • 260,337 Sqft
    Availability
    • 1 Space
    • 13,943 Sqft
    Year Built
    • 2002
    View Details
  • 90 South Spruce - S San Francisco
    90 Spruce Ave, S., Orange Park, S San Francisco, CA
    For Lease
    • $25.8 - $33/Sqft/Year
    Property
    • Industrial
    • 36,410 Sqft
    Availability
    • 4 Spaces
    • 5,202 Sqft
    Year Built
    • 1900
    View Details
  • 100-130 Produce Avenue - South San Francisco
    100 Produce Avenue, Lindenville, South San Francisco, CA
    For Lease
    • $9.6 - $19.5/Sqft/Year
    Property
    • Office
    • 41,448 Sqft
    Availability
    • 2 Spaces
    • 3,917 Sqft
    Year Built
    • 1986
    View Details
  • Oyster Point Marina Plaza II - S San Francisco
    395 Oyster Point Blvd, Oyster Point, S San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 232,733 Sqft
    Availability
    • 16 Spaces
    • 90,911 Sqft
    Year Built
    • 1986
    View Details
  • The Gateway Technology Center - 630 Gateway Blvd - South San Francisco
    630 Gateway Blvd, The East Side, South San Francisco, CA
    For Lease
    • $66/Sqft/Year
    Property
    • Office
    • 50,160 Sqft
    Availability
    • 1 Space
    • 50,160 Sqft
    Year Built
    • 2001
    View Details
  • The Gateway Technology Center - 600 Gateway Blvd - South San Francisco
    600 Gateway Blvd, The East Side, South San Francisco, CA
    For Lease
    • $5.75/Sqft/Month
    Property
    • Office
    • 81,308 Sqft
    Availability
    • 2 Spaces
    • 14,000 Sqft
    Year Built
    • 1998
    View Details
  • 701 Gateway - South San Francisco
    701 Gateway Blvd, Gateway, South San Francisco, CA
    For Lease
    • $54/Sqft/Year
    Property
    • Office
    • 170,323 Sqft
    Availability
    • 2 Spaces
    • 13,709 Sqft
    Year Built
    • 1999
    View Details
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  • 7000 Shoreline Court - South San Francisco
    7000 Shoreline Court, Paradise Valley, South San Francisco, CA
    For Lease
    • $84/Sqft/Year
    Property
    • Office
    • 136,395 Sqft
    Availability
    • 3 Spaces
    • 39,430 Sqft
    Year Built
    • 2003
    View Details
  • 701 Gateway - S San Francisco
    701 Gateway Blvd, Gateway, S San Francisco, CA
    For Lease
    • $39/Sqft/Year
    Property
    • Office
    • 176,036 Sqft
    Availability
    • 1 Space
    • 4,293 Sqft
    Year Built
    • 1999
    View Details
  • Genesis - North Tower - South San Francisco
    2 Tower Place, Paradise Valley, South San Francisco, CA
    For Lease
    • $69/Sqft/Year
    Property
    • Office
    • 381,523 Sqft
    Availability
    • 3 Spaces
    • 34,267 Sqft
    Year Built
    • 2018
    View Details
  • Oyster Point Marina Plaza I - S San Francisco
    400 Oyster Point Blvd, Oyster Point, S San Francisco, CA
    For Lease
    • $40.8 - $42/Sqft/Year
    Property
    • Office
    • 231,769 Sqft
    Availability
    • 18 Spaces
    • 30,074 Sqft
    Year Built
    • 1986
    View Details
  • 400 Oyster Point Blvd - South San Francisco
    400 Oyster Point Blvd, Oyster Point, South San Francisco, CA
    For Lease
    • $33/Sqft/Year
    Property
    • Office
    • 234,480 Sqft
    Availability
    • 1 Space
    • 2,314 Sqft
    Year Built
    • 1985
    View Details
  • Airport Boulevard - South San Francisco
    11 Airport Blvd, Paradise Valley, South San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 52,327 Sqft
    Availability
    • 3 Spaces
    • 2,744 Sqft
    Year Built
    • 1987
    View Details
  • Britannia Modular Labs II - South San Francisco
    333 Allerton Avenue, The East Side, South San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 70,000 Sqft
    Availability
    • 2 Spaces
    • 34,409 Sqft
    Year Built
    • 1972
    View Details
  • Britannia Modular Labs I - 285 East Grand Avenue - South San Francisco
    285 East Grand Avenue, The East Side, South San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 61,770 Sqft
    Availability
    • 1 Space
    • 23,000 Sqft
    Year Built
    • 2006
    View Details
  • GENESIS TOWERS - South San Francisco
    1 Tower Pl South, Paradise Valley, South San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    Availability
    • 1 Space
    • 87,067 Sqft
    Year Built
    • 2008
    View Details
  • Produce Avenue - South San Francisco
    100 Produce Avenue, Lindenville, South San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 41,448 Sqft
    Availability
    • 4 Spaces
    • 8,199 Sqft
    Year Built
    • 1986
    View Details
  • 681 Gateway Blvd - South San Francisco
    681 Gateway Blvd, Gateway, South San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 126,971 Sqft
    Availability
    • 2 Spaces
    • 65,914 Sqft
    Year Built
    • 2006
    View Details
  • 343 Oyster Point Blvd - South San Francisco
    343 Oyster Point Blvd, Oyster Point, South San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 53,980 Sqft
    Availability
    • 1 Space
    • 20,315 Sqft
    Year Built
    • 2001
    View Details
  • Britannia Biotech Gateway Center I - 1 Corporate Drive - South San Francisco
    1 Corporate Drive, Gateway, South San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 71,479 Sqft
    Availability
    • 1 Space
    • 36,000 Sqft
    Year Built
    • 1999
    View Details
  • The Gateway North Campus - 951 Gateway Blvd - South San Francisco
    951 Gateway Blvd, Gateway, South San Francisco, CA
    For Lease
    • Contact for pricing
    Property
    • Office
    • 59,816 Sqft
    Availability
    • 2 Spaces
    • 39,000 Sqft
    Year Built
    • 2002
    View Details
  • Kilroy Oyster Point - Phase I - San Francisco
    379 Oyster Point Blvd, Oyster Point, San Francisco, CA
    For Lease
    • $1.45 - $2.5/Sqft/Month
    Property
    • Office
    • 656,000 Sqft
    Availability
    • 4 Spaces
    • 41,410 Sqft
    Year Built
    • 2021
    View Details
  • 192 Beacon St - South San Francisco
    192 Beacon St, San Bruno Canal, South San Francisco, CA
    For Lease
    • $2.75/Sqft/Month
    Property
    • Office
    • 8,000 Sqft
    Availability
    • 1 Space
    • 8,000 Sqft
    View Details

South San Francisco, CA Office Space Listings

There are currently 123 office listings available in South San Francisco, CA. These listings include 103 office spaces that encompass a total of 2,243,188 square feet. Available office spaces in South San Francisco, CA range in size from 305 square feet to 900,000 square feet. A total of 84 off-market office properties located in South San Francisco, CA are also available for research.

Look For Office Space Near Me

Are you still looking for the office space near you that’s perfect for your business? Browse through all available CommercialCafe listings in your area to find the right fit — the space that meets your requirements, right now and for the future. Easily compare sizes, prices, amenities and locations of office spaces for rent near me. Expand your search beyond your neighborhood and ZIP code and search our listings in any city or state to find the best fit for your needs, wherever you are in the U.S. The perfect office space for rent near South San Francisco, CA is only one search away.

South San Francisco, CA Commercial Inventory Breakdown

Office Spaces

Total: 20,097,392 SF

Data provided by Yardi Matrix, properties over 50k SF, includes office with retail

By square footage range:

  • 50k to 100k SF: 1,961,746 SF / 9.76% of total office
  • 100k to 500k SF: 12,787,655 SF / 63.63% of total office
  • 500k to 1M SF: 3,939,630 SF / 19.6% of total office
  • > 1M SF: 1,408,361 SF / 7.01% of total office

By class:

  • Class A: 11,316,183 SF / 56.31% of total office
  • Class B: 3,944,380 SF / 19.63% of total office

Top 10 Largest Office Buildings

in South San Francisco

Office building Address Sqft Year built
Genentech Headquarters - Lower Main Campus 1 DNA Way, 94080 1,408,361 1970
Kilroy Oyster Point - Phase I 379 Oyster Point Blvd, 94080 656,000 2021
Gateway of Pacific I 1000 Gateway Blvd, 94080 509,000 2021
Gateway of Pacific II 750 Gateway Blvd, 94080 440,000 2021
Genesis - North Tower 2 Tower Place, 94080 381,523 2018
Gateway of Pacific III 700 Gateway Blvd, 94080 360,000 2021
201 Haskins Way 201 Haskins Way, 94080 311,368 2021
The Merck Campus 221 East Grand Avenue, 94080 294,000 2019
Genentech Headquarters - Mid Main Campus - Buildings 13-15 340 Point San Bruno Blvd, 94080 277,814 2003
Genentech Headquarters - Mid Main Campus - Buildings 10-12 & 36 99 DNA Way, 94080 276,044 1975

Largest Office Properties Recently Completed

in South San Francisco

Office building Address Sqft Year built
Kilroy Oyster Point - Phase I 379 Oyster Point Blvd, 94080 656,000 2021
Gateway of Pacific I 1000 Gateway Blvd, 94080 509,000 2021
Gateway of Pacific II 750 Gateway Blvd, 94080 440,000 2021
Gateway of Pacific III 700 Gateway Blvd, 94080 360,000 2021
201 Haskins Way 201 Haskins Way, 94080 311,368 2021
The Cove at Oyster Point V 181 Oyster Point Blvd, 94080 164,150 2020
The Merck Campus 221 East Grand Avenue, 94080 294,000 2019
279 East Grand Avenue 279 East Grand Avenue, 94080 211,405 2019
The Cove at Oyster Point VII 131 Oyster Point Blvd, 94080 175,830 2019
Britannia East Grand: Genentech Headquarters - South Campus - Building 40 500 East Grand Avenue, 94080 160,582 2019

Frequently Asked Questions

How much does office space cost in South San Francisco, CA?

The average office rental rate in South San Francisco, CA is $43.12 per square foot. Asking prices vary based on the property’s location, overall rating, amenities, proximity to restaurants, cafes and entertainment venues, as well as public transport, airports and highways. Check South San Francisco Office Market Trends for more stats.

What is the size of available office spaces in South San Francisco, CA?

The South San Francisco, CA office market can accommodate various businesses, sporting a range of office space availabilities. The average size of office space availabilities is 450,153 square feet. If you’re just starting out as a company or as an entrepreneur, the smallest available office space in South San Francisco, CA is 305 square feet, while the maximum rentable space on the market now is 900,000 square feet.

How do I get office space in South San Francisco, CA?

Start your search for office space in South San Francisco, CA by using our filters that allow you to find the best space for your business needs. Filter listings by location, property size, available space or lease rate. Property pages will offer details about an office building’s rating, year built, availabilities, price per square foot and more. After drawing up a shortlist, make sure you contact the listed broker(s) to schedule a viewing and begin the negotiation process for your lease contract.

How many office listings are available in South San Francisco, CA?

There are 123 office listings on the South San Francisco, CA market. See all available office spaces for rent.

Where to rent an office space in South San Francisco, CA?

Popular South San Francisco neighbourhoods with available office spaces include The East Side, Oyster Point and Gateway.

What other property types are available for lease in South San Francisco, CA?

In addition to traditional office spaces, commercial real estate listings on our platform also include coworking & shared office space options, retail spaces, industrial buildings, warehouses, distribution facilities, and more.

South San Francisco Demographics

Population

  • Total Population67,408
  • Male Population(49.1 %) 33,121
  • Female Population(50.9 %) 34,287
  • Median Age40.40

Income/Financial

  • Average Household Income$129,300
  • Median Household Income$105,459
  • Median Income Under 25$97,100
  • Median Income 25-44$117,273
  • Median Income 45-64$122,594
  • Median Income Over 65$71,715