South San Francisco, CA Commercial Real Estate for Lease and Sale
Explore 125 listings of South San Francisco commercial real estate to find the best space for your business.
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274 Wattis Way, San Bruno Canal, South San Francisco, CAProperty- Industrial
- 50,000 SF
Availability- 1 Space
- 11,150 SF
Year Built- 1958
For Lease- $1.75/SF/MO
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310 Littlefield Avenue, The East Side, South San Francisco, CAProperty- Industrial
- 64,425 SF
Availability- 2 Spaces
- 22,260 SF
Year Built- 1975
For Lease- $0.89 - $1.15/SF/MO
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889 McLellan Drive, Sunshine Gardens, South San Francisco, CAProperty- Retail
- 5,481 SF
Year Built- 2025
For Sale- Call for Pricing
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260 Littlefield Avenue, The East Side, South San Francisco, CAProperty- Office
- 169,359 SF
Availability- 2 Spaces
- 46,668 SF
Year Built- 1988
For Lease Contact for pricing -
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611 Gateway Blvd, Gateway, S San Francisco, CAProperty- Office
- 260,337 SF
Availability- 1 Space
- 24,768 SF
Year Built- 2002
For Lease Contact for pricing -
238-242 Lawrence Ave, The East Side, S San Francisco, CAProperty- Industrial
- 80,524 SF
Availability- 1 Space
- 40,420 SF
Year Built- 1986
For Lease Contact for pricing -
30 Tanforan Avenue, Lindenville, South San Francisco, CAProperty- Office
- 375,000 SF
Availability- 1 Space
- 325,000 SF
Year Built- 2024
For Lease Contact for pricing -
453 Forbes Blvd, The East Side, South San Francisco, CAProperty- Industrial
- 38,102 SF
Availability- 1 Space
- 40,606 SF
Year Built- 1967
For Lease Contact for pricing -
400 S Airport Blvd, San Bruno Canal, South San Francisco, CAProperty- Retail
Availability- 1 Space
- 5,124 SF
Year Built- 1965
For Lease- $0.55/SF/MO
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1 Tower Place, Paradise Valley, South San Francisco, CAProperty- Office
- 324,986 SF
Availability- 6 Spaces
- 162,281 SF
Year Built- 2009
For Lease Contact for pricing -
915 Airport Boulevard, Paradise Valley, South San Francisco, CA -
901 Gateway Blvd, Gateway, South San Francisco, CAProperty- Office
- 110,428 SF
Availability- 3 Spaces
- 78,070 SF
Year Built- 2000
For Lease- $4.50/SF/MO
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90 South Spruce Avenue, Orange Park, South San Francisco, CAProperty- Office
- 36,000 SF
Availability- 1 Space
- 11,261 SF
Year Built- 1986
For Lease Contact for pricing -
229 Littlefield Ave, The East Side, S San Francisco, CAProperty- Industrial
- 315,000 SF
Availability- 1 Space
- 45,000 SF
Year Built- 1960
For Lease Contact for pricing -
111 Pine Ave, Downtown South San Francisco, South San Francisco, CAProperty- Office
Availability- 1 Space
- 6,425 SF
Year Built- 1956
For Lease- $2.45/SF/MO
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101 McLellan Drive, Sunshine Gardens, South San Francisco, CA -
400 East Jamie Court, The East Side, South San Francisco, CAProperty- Office
- 88,284 SF
Availability- 1 Space
- 7,833 SF
Year Built- 2009
For Lease Contact for pricing -
407 Cabot Rd, The East Side, South San Francisco, CAProperty- Flex Space
- 919 SF
Availability Contact for availabilityYear Built- 1965
For Lease Contact for pricing -
3573 Callan Blvd, North Westborough, South San Francisco, CAProperty- Retail
Availability- 1 Space
- 1,223 SF
Year Built- 1965
For Lease- $4.00/SF/MO
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611 Gateway Boulevard #120, South San Francisco, CAServices- Virtual Office
- Open Workspace
- Private Office
- Dedicated Desk
Amenities -
701-703 Linden Ave, Downtown South San Francisco, South San Francisco, CAProperty- Retail
Availability- 1 Space
- 2,800 SF
Year Built- 1930
For Lease- $3.95/SF/MO
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341 Swift Avenue, The East Side, South San Francisco, CAProperty- Industrial
- 67,058 SF
Availability- 2 Spaces
- 16,678 SF
Year Built- 1978
For Lease- $1.55 - $2.15/SF/MO
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161 El Camino Real, Brentwood Park, South San Francisco, CAProperty- Office
- 3,010 SF
Year Built- 2017
For Sale- $1,799,000
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494 Forbes Blvd, The East Side, South San Francisco, CAProperty- Office
- 188,000 SF
Availability- 5 Spaces
- 107,175 SF
Year Built- 2024
For Lease Contact for pricing -
1435-1475 Huntington Ave, Lindenville, S San Francisco, CA -
131 Oyster Point Blvd, Oyster Point, South San Francisco, CAProperty- Office
- 175,830 SF
Availability- 2 Spaces
- 49,093 SF
Year Built- 2019
For Lease Contact for pricing -
240-242 Lawrence Ave, The East Side, S San Francisco, CAProperty- Industrial
- 40,000 SF
Availability- 1 Space
- 9,796 SF
For Lease- $24.00/SF/YR
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400 Oyster Point Blvd, Oyster Point, South San Francisco, CAProperty- Office
- 234,480 SF
Availability- 1 Space
- 40,000 SF
Year Built- 1985
For Lease Contact for pricing -
201 Haskins Way, The East Side, South San Francisco, CAProperty- Office
- 311,368 SF
Availability- 2 Spaces
- 36,163 SF
Year Built- 2021
For Lease- $72.00/SF/YR
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263 Utah Avenue, The East Side, South San Francisco, CAProperty- Industrial
- 33,280 SF
Availability- 1 Space
- 12,104 SF
Year Built- 1965
For Lease- $1.50/SF/MO
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229 Harbor Way, The East Side, South San Francisco, CA -
7000 Shoreline Court, Paradise Valley, South San Francisco, CAProperty- Office
- 136,395 SF
Availability- 1 Space
- 4,746 SF
Year Built- 2003
For Lease Contact for pricing -
250 East Grand Avenue, The East Side, South San Francisco, CAProperty- Office
- 630,500 SF
Availability- 9 Spaces
- 316,970 SF
Year Built- 1989
For Lease Contact for pricing -
650 Gateway Blvd, The East Side, South San Francisco, CAProperty- Office
- 50,400 SF
Availability- 2 Spaces
- 15,234 SF
Year Built- 1999
For Lease Contact for pricing -
225 Gateway Blvd, Gateway, South San Francisco, CAProperty- Office
- 106,076 SF
Availability- 5 Spaces
- 113,979 SF
Year Built- 1998
For Lease Contact for pricing -
343 Oyster Point Blvd, Oyster Point, South San Francisco, CAProperty- Office
- 53,980 SF
Availability- 2 Spaces
- 34,090 SF
Year Built- 2001
For Lease- $6.75/SF/MO
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570-586 Eccles Ave, The East Side, S San Francisco, CAProperty- Industrial
- 375,000 SF
Availability- 2 Spaces
- 137,730 SF
Year Built- 1965
For Lease Contact for pricing -
250 Hillside Blvd, Paradise Valley, South San Francisco, CAProperty- Industrial
- 28,726 SF
Availability- 1 Space
- 29,800 SF
Year Built- 1951
For Lease- $1.50 - $1.75/SF/MO
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233 East Grand Avenue, The East Side, South San Francisco, CAProperty- Office
- 148,500 SF
Availability- 2 Spaces
- 54,000 SF
Year Built- 2023
For Lease Contact for pricing -
285 East Grand Avenue, The East Side, South San Francisco, CAProperty- Office
- 61,770 SF
Availability- 2 Spaces
- 62,000 SF
Year Built- 2006
For Lease Contact for pricing -
333 Oyster Point Blvd, Oyster Point, South San Francisco, CAProperty- Office
- 121,760 SF
Availability- 1 Space
- 30,140 SF
Year Built- 2008
For Lease Contact for pricing -
233 E Harris Ave, The East Side, South San Francisco, CAProperty- Industrial
Availability- 1 Space
- 60,000 SF
Year Built- 1979
For Lease- $1.55/SF/MO
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499 Forbes Blvd, The East Side, South San Francisco, CAProperty- Flex Space
- 144,209 SF
Availability Contact for availabilityYear Built- 2022
For Lease Contact for pricing -
419 Grand Ave, Downtown South San Francisco, South San Francisco, CAProperty- Retail
Availability- 1 Space
- 1,166 SF
Year Built- 1960
For Lease- $3.30/SF/MO
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100 Kimball Way, The East Side, South San Francisco, CAProperty- Office
- 104,930 SF
Availability- 2 Spaces
- 25,991 SF
Year Built- 1968
For Lease Contact for pricing -
2 Corporate Dr, Gateway, S San Francisco, CAProperty- Unassigned
- 83,411 SF
Availability- 1 Space
- 46,280 SF
Year Built- 1998
For Lease Contact for pricing -
501 Airport Blvd, Downtown South San Francisco, South San Francisco, CAProperty- Retail
Availability- 1 Space
- 3,750 SF
Year Built- 1985
For Lease- $1.95/SF/MO
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2 Tower Place, Paradise Valley, S San Francisco, CAProperty- Unassigned
- 374,433 SF
Availability- 4 Spaces
- 78,093 SF
Year Built- 2018
For Lease Contact for pricing -
434 N Canal St, Lindenville, South San Francisco, CAProperty- Industrial
Availability- 1 Space
- 2,550 SF
Year Built- 1990
For Lease- $2.50/SF/MO
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390 Swift Ave, The East Side, S San Francisco, CA -
245 South Spruce Avenue, Lindenville, South San Francisco, CAProperty- Industrial
- 559,605 SF
Availability- 5 Spaces
- 10,250 SF
Year Built- 1957
For Lease- $26.28 - $37.32/SF/YR
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619 Airport Blvd, Downtown South San Francisco, South San Francisco, CAProperty- Office
Availability- 1 Space
- 7,662 SF
Year Built- 1956
For Lease- $2.45/SF/MO