South San Francisco, CA Commercial Real Estate for Lease and Sale

Explore 114 listings of South San Francisco commercial real estate to find the best space for your business.

988 El Camino Real

988 El Camino Real, Orange Park, South San Francisco, CA
Property

Retail

10,000 SF
Availability

3 Spaces

2,231 SF
Year Built

2022
For Lease Contact for pricing
View Details (opens in new window)
340 Shaw

340 Shaw Rd, Lindenville, S San Francisco, CA
Property

Industrial

25,141 SF
Availability

1 Space

25,141 SF
For Lease Contact for pricing
View Details (opens in new window)
OFFICE SPACE FOR LEASE

220 S Spruce Ave, Orange Park, South San Francisco, CA
Property

Office
Availability

1 Space

1,550 SF
Year Built

1984
For Lease

$2.25/SF/MO
View Details (opens in new window)
121 Maple

121 Maple Ave, S., Lindenville, S San Francisco, CA
Property

Industrial

38,750 SF
Year Built

1978
For Sale

$1,250,000
View Details (opens in new window)
Gateway of Pacific V - North Building

475 Eccles Avenue, The East Side, South San Francisco, CA
Property

Office

160,000 SF
Availability

4 Spaces

129,600 SF
Year Built

2024
For Lease

$7.25/SF/MO
View Details (opens in new window)
Gateway of Pacific IV

900 Gateway Blvd, The East Side, San Francisco, CA
Property

Office

405,000 SF
Availability

9 Spaces

249,993 SF
For Lease Contact for pricing
View Details (opens in new window)
200 Airport Blvd

200 Airport Blvd, San Bruno Canal, South San Francisco, CA
Property

Retail

3,634 SF
Availability

1 Space

1,977 SF
For Lease Contact for pricing
View Details (opens in new window)
201 Cypress Ave

201 Cypress Ave, Downtown South San Francisco, South San Francisco, CA
Property

Industrial

10,067 SF
For Sale

$2,900,000
View Details (opens in new window)
OFFICE SPACE FOR LEASE

301 Grand Ave, Downtown South San Francisco, South San Francisco, CA
Property

Office
Availability

1 Space

3,689 SF
Year Built

1973
For Lease

$1.66/SF/MO
View Details (opens in new window)
100 Grand

100 Grand Ave, E., Downtown South San Francisco, S San Francisco, CA
Property

Industrial

70,728 SF
Availability

1 Space

20,728 SF
Year Built

1954
For Lease Contact for pricing
View Details (opens in new window)

Frequently Asked Questions

Commercial real estate is a broad category that includes a high variety of space types designed to meet the needs of various industries of the local economy and their specialized subsectors, as presented in our real estate 101 guide to types of commercial real estate. However, there are three main categories that you are most likely to come across: office, retail, and industrial space.
- Modern office space is typically organized over large floor plates bound by high ceilings and large windows for an abundance of natural light and is located in transit-oriented developments with good access to multiple modes of transportation, so as to facilitate employee commute. The South San Francisco commercial real estate market incorporates 6,795,487 square feet of office space across 40 buildings.
  
  Office buildings can also accommodate coworking spaces, which are shared office options that typically cater to the needs of small, startup businesses that require flexible workspaces, a concentration of amenities, and services that can be accessed on an occasional or short-term basis.
- Retail space includes shopping malls, department stores, street retail, or specialty stores dedicated to a narrow range of products. Such properties are typically located in high foot-traffic and/or car traffic areas, to facilitate customer access. The South San Francisco commercial real estate market includes 110,223 square feet of retail space in a variety of settings.
- Industrial property most often serves businesses operating in manufacturing or logistics and generally consists of large open spaces located within good access to roads, railways, freight airports or regional water ports. Industrial space listings can include warehouses, manufacturing plants, distribution centers, flexible industrial space, or even data center facilities. Across the South San Francisco market, there is a total of 2,634,126 square feet of industrial property.
The listing inventory in South San Francisco incorporates commercial real estate for lease and for sale of almost all property types and subtypes. However, you’ll find some categories offer more rental or investment opportunities than others.

The largest share of commercial real estate space for lease in South San Francisco is represented by Office space, which accounts for 3,325,940 square feet of available listings. Industrial space available in South San Francisco adds up to 792,489 square feet.

Meanwhile, most of the listings of commercial property for sale in South San Francisco are in the Industrial category.
The price of renting or buying commercial real estate is influenced by a variety of factors, including: the property type (for example, office space is priced higher than other property types in most locations); the condition and asset class rating (property rated class A or above will typically command a higher price than lower grade classifications); the quality or the development potential of the property location; whether or not there is high demand for the type of commercial asset in question; and what the state of supply is relative to demand.
The average rent for commercial real estate space listed for lease in South San Francisco is $28.57 per square foot. However, this value does not offer enough perspective on its own, as you will find significant variation in prices across property types, property classes, and location, as well as other impacting factors. For instance, rent per square foot of office space in South San Francisco can vary greatly depending on the rating of the property from Class A to Class C, as well as across the city depending on the location of the asset. What’s more, each commercial property type makes its own rent market: while the average rent for office space rested at $86.62 per square foot, industrial space in South San Francisco saw average rents of $22.35 per square foot.
Whether you are looking for commercial real estate for lease or commercial property for sale, the best choice of location depends on the factors that are most relevant to your business strategy. A good thing to look for at the start, however, is the areas of the city that have the highest concentration of your preferred type of property, as these areas are generally well connected to the amenities and points of interest that are most relevant to each property type.

As such, there are several areas that you could consider to be the best location for commercial real estate in South San Francisco, depending on the property type you are interested in. The highest concentration of commercial space listings of any kind in South San Francisco is in the The East Side neighborhood. But if we look at each commercial property type, we find that for office space, the best location is the The East Side area.

Meanwhile, retail space opportunities are most abundant in the Downtown South San Francisco submarket. Alternatively, if you are looking for warehouse or other industrial space, consider looking at listings in The East Side.

Select your preferred property type from the search filters menu at the top of the search page and then navigate the interactive map for a better view of commercial real estate availability in the locations most suited to your needs.
Regardless of whether buying or leasing commercial space is a new experience for you, there are significant benefits to working with a commercial real estate broker. In addition to saving you time and money, an experienced broker will contribute specialist knowledge of the local market, the property type you need representation for, and will handle negotiations on your behalf in your best interest.

To start, it is important for you to have a good understanding of what kind of broker you need. For instance, there are differences between a tenant broker and a listing broker. Also important at the start is to have a clear idea of what kind of space (or tenant) you are looking for and what (if any) particular needs and requirements you might have. And, while it is good to get a referral, you should interview several brokers to better gauge who you feel would best represent your interests.

CommercialCafe hosts listings from some of the most trusted commercial real estate brokerages in the country. Use the contact form available on each listing page or the contact details for the property representatives to reach out and start your search!
The profitability of a commercial real estate investment depends on a multitude of factors working together. These factors include the quality of the asset itself — which itself includes aspects such as location, property class, amenities, and the quality of the property management — to the local market conditions, the state of the local economy, the demand for that particular type of commercial property, and of course the costs of owning and maintaining it relative to what leasing rate or sale price you get from the property. Asking rents in the city went as high as $60 per square foot. In particular, the property type commanding the highest lease rates in South San Francisco was Office space.
The average size of a commercial property in South San Francisco depends greatly on the property type and the location — geographical possibilities and zoning allowances have significant influence on how big developers can build. While there are outliers that break height or volume records in the city, we can look at some average sizes by property use:
- In South San Francisco, the average size of an office property is 212,359 square feet.
- Retail properties here incorporate an average of 15,747 square feet.
- Industrial space in South San Francisco is in buildings that are, on average 69,320 square feet in size.

South San Francisco, CA Currently Available Listings

Commercial Space for Lease Breakdown

Commercial real estate listings for rent in South San Francisco currently add up to 4,599,895 square feet. The market offers 38 active office listing(s), which amount to 3,325,940 square feet and account for 44% of commercial spaces on the market. Local retail availability includes 91,398 square feet across 12 retail space(s). Industrial space for rent opportunities in South San Francisco amount to 792,489 square feet across a total of 32 warehouse and other industrial listing(s).

Property Type	Count of Listings	Total SF
Office	38	3,325,940
Retail	12	91,398
Industrial	32	792,489
Other	4	390,068

Commercial Space for Sale Breakdown

What’s more, if you are interested in making an investment in the local market, you can also find commercial real estate for sale in South San Francisco, CA. Currently, there is 409,891 square feet of commercial property for sale here , which includes 2 office building(s) for sale , 2 retail investment opportunity listing(s) , and 15 listing(s) of industrial real estate property for sale .

Property Type	Count of Listings	Total SF
Office	2	30,018
Retail	2	10,979
Industrial	15	363,454
Other	2	5,440

About us

CommercialCafe is your go-to commercial real estate listing source. We partner with highly respected major brokerages from across the country to ensure high-quality listings that are updated frequently. Our online marketplace lists all commercial property types from office, coworking, retail, and industrial to special purpose properties.

CommercialCafe is a trusted Yardi brand and is an integral part of the CommercialEdge network — the fastest-growing network of online real estate marketplaces, which ranks on the 1st page of Google for all top markets, attracts more than 2 million monthly visits, and generates more than 350,000 broker contacts.

South San Francisco, CA Commercial Real Estate for Lease and Sale

988 El Camino Real

340 Shaw

OFFICE SPACE FOR LEASE

121 Maple

Gateway of Pacific V - North Building

Gateway of Pacific IV

200 Airport Blvd

201 Cypress Ave

OFFICE SPACE FOR LEASE

100 Grand

Frequently Asked Questions

South San Francisco, CA Currently Available Listings

Commercial Space for Lease Breakdown

Commercial Space for Sale Breakdown

Other Popular Searches

Popular Coworking Searches

Popular Office Searches

Popular Retail Searches

Popular Industrial Searches

About us

About Us

Our Tools