South San Francisco, CA Office Spaces for Rent

Find your best South San Francisco, CA office space among 185 for rent listings, which average an asking price of $86.62 per square foot.

Office Market FAQs

Lilly Gateway Labs - South San Francisco
Lilly Gateway Labs
681 Gateway Boulevard, South San Francisco, CA
Space Type

Private Offices
For Lease

Contact for pricing
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Gateway of Pacific IV

900 Gateway Blvd, The East Side, San Francisco, CA
Space Type

Office
For Lease Contact for pricing

9 spaces available / 27,777 SF
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OFFICE SPACE FOR LEASE

220 S Spruce Ave, Orange Park, South San Francisco, CA
Space Type

Office
For Lease

$0.19/SF/MO
2 spaces available / 1,668 - 2,160 SF
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OFFICE SPACE FOR LEASE

301 Grand Ave, Downtown South San Francisco, South San Francisco, CA
Space Type

Office
For Lease

$0.14/SF/MO
1 space available / 3,689 SF
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1486 Huntington Avenue

1486 Huntington Ave, Lindenville, South San Francisco, CA
Space Type

Office
For Lease

$0.24/SF/MO
1 space available / 2,621 SF
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216-218 Linden Ave

216-218 Linden Ave, Downtown South San Francisco, South San Francisco, CA
Space Type

Office
For Lease Contact for pricing

3 spaces available / 245 - 933 SF
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South San Francisco, CA Office Space for Rent

Office inventory

According to our listing data, South San Francisco's office market contains 18.6M square feet of space as of 2026.

South San Francisco Office Market Breakdown by Building Size
Building Size Range	Total Square Feet
50k to 100k Sq. Ft.	2.1M Sq. Ft.
100k to 500k Sq. Ft.	12M Sq. Ft.
500k to 1M Sq. Ft.	2.7M Sq. Ft.
> 1M Sq. Ft.	1.4M Sq. Ft.

Data was provided by Yardi Research Data, refers to properties larger than 50,000 square feet.

Properties sized 100k to 500k Sq. Ft. make up most of the local office inventory, amounting to 12M square feet.

Average Rent for Office Spaces

The average rent for office space in South San Francisco is $18 per square foot. However, you can find rental rates as low as $1 per square foot here, depending on what compromises you are willing to make. If you are looking for office space priced at a certain value, you can use the filters at the top of the page to look for properties within your optimal range.

The maximum rental rate is $48 per square foot among local listings currently available for lease.

For our detailed analysis of the latest rent and sale prices in South San Francisco, as well as overall market quality and new construction data, see South San Francisco Office Market Trends.

Office Spaces Classes

The office space market in South San Francisco incorporates a mix of properties of various ages, ratings, construction grades, and other quality indicators. 76.98% of total office listings in this city are in properties rated Class A. Class B accounts for 20.03% of traditional work spaces listed on the leasing market. Class C makes up 2.99% of such listings in South San Francisco. This data is current as of 2026.

South San Francisco Office Market Breakdown by Building Class
Class	Total Square Feet	Share of Total Office
A	14.3M	76.98%
B	3.7M	20.03%
C	555.1K	2.99%

Data was provided by Yardi Research Data, refers to properties larger than 50,000 square feet.

Top Neighborhoods for Office Space

Location is everything when it comes to office spaces. Tenants place great value on well positioned properties in amenity-rich areas, potentially boosting office attendance.

In South San Francisco, the greatest concentration of lease opportunities is in The East Side, Gateway and Oyster Point.

Office Classes in South San Francisco, California Neighborhoods

Gateway

Oyster Point

The East Side

Class A+/A
Class B
Class C

The Gateway neighborhood contains the most Class A office space, attracting premium tenants and corporate headquarters. Meanwhile, the neighborhood with the most Class B space is The East Side, offering quality space at affordable rates.

South San Francisco, CA in the news

South San Francisco Life Sciences Campus Gets Expansion Approval

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South San Francisco, CA Office Spaces for Rent

Lilly Gateway Labs - South San Francisco

Gateway of Pacific IV

OFFICE SPACE FOR LEASE

OFFICE SPACE FOR LEASE

1486 Huntington Avenue

216-218 Linden Ave