South San Francisco, CA Office Spaces for Rent

Find your best South San Francisco, CA office space among 197 for rent listings, which average an asking price of $82.96 per square foot.

Office Market FAQs

Discovery Station - Building 2

182 El Camino Real, Lindenville, South San Francisco, CA
Space Type

Office
For Lease Contact for pricing

1 space available / 280,002 SF
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Gateway of Pacific IV

900 Gateway Blvd, The East Side, San Francisco, CA
Space Type

Office
For Lease Contact for pricing

9 spaces available / 27,777 SF
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101 Linden Ave

101 Linden Ave, Downtown South San Francisco, South San Francisco, CA
Space Type

Office
For Lease Contact for pricing

1 space available / 3,500 SF
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Discovery Station - Building 3

188 El Camino Real, Lindenville, South San Francisco, CA
Space Type

Office
For Lease Contact for pricing

1 space available / 259,998 SF
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458 Carlton Ct

458 Carlton Ct, The East Side, South San Francisco, CA
Space Type

Office
For Lease

$0.42/SF/MO
1 space available / 2,627 SF
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OFFICE SPACE FOR LEASE

220 S Spruce Ave, Orange Park, South San Francisco, CA
Space Type

Office
For Lease

$0.19/SF/MO
2 spaces available / 1,668 - 2,160 SF
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400 Oyster Point Blvd, Suite 335

400 Oyster Point Blvd, Suite 335, Oyster Point, South San Francisco, CA
Space Type

Office
For Lease

$43.92/SF/YR
1 space available / 3,105 SF
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Infinite

101 Terminal Court, Lindenville, South San Francisco, CA
Space Type

Office
For Lease Contact for pricing

1 space available / 2,500,000 SF
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425 Eccles Ave

425 Eccles Ave, The East Side, South San Francisco, CA
Space Type

Office
For Lease

$0.33/SF/MO
1 space available / 20,935 SF
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OFFICE SPACE FOR LEASE

301 Grand Ave, Downtown South San Francisco, South San Francisco, CA
Space Type

Office
For Lease

$0.14/SF/MO
1 space available / 3,689 SF
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216-218 Linden Ave

216-218 Linden Ave, Downtown South San Francisco, South San Francisco, CA
Space Type

Office
For Lease Contact for pricing

3 spaces available / 245 - 933 SF
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Frequently Asked Questions

In South San Francisco, office spaces range from smaller units to larger options. On average, office spaces in this area tend to be about 40,067 square feet. However, the largest listings can go up to 2,500,000 square feet for an individual listing. This can give you a good starting point to compare with your needs.
In South San Francisco, you have several options when it comes to leasing office space. To better understand what to look for, check out our definitive guide to finding office space for your small business or startup. Here is an overview of the most common types currently available:
- Most Common Office Type
  The most frequent subtype available for lease is Life Sciences, which makes up 59.34% of all listings in the city.
- Second-Most Common Office Type
  The second-most common office space type listed here is R&D - Office, accounting for 26.37% of available listings.
- Third-Most Common Office Type
  Up next, General Office also makes up a significant portion of listings, offering additional options for those seeking alternative spaces.
You can find a total of 197 listings for lease in South San Francisco, which add up to a total of 7,051,736 square feet. Out of these listings, 20 are sublease listings, with the highest concentration of sublease listings being located in The East Side

South San Francisco, CA Office Space for Rent

Office inventory

According to our listing data, South San Francisco's office market contains 18.2M square feet of space as of 2026.

South San Francisco Office Market Breakdown by Building Size
Building Size Range	Total Square Feet
50k to 100k Sq. Ft.	2.2M Sq. Ft.
100k to 500k Sq. Ft.	11.5M Sq. Ft.
500k to 1M Sq. Ft.	2.7M Sq. Ft.
> 1M Sq. Ft.	1.4M Sq. Ft.

Data was provided by Yardi Research Data, refers to properties larger than 50,000 square feet.

Properties sized 100k to 500k Sq. Ft. make up most of the local office inventory, amounting to 11.5M square feet.

Average Rent for Office Spaces

The average rent for office space in South San Francisco is $19 per square foot. However, you can find rental rates as low as $1 per square foot here, depending on what compromises you are willing to make. If you are looking for office space priced at a certain value, you can use the filters at the top of the page to look for properties within your optimal range.

The maximum rental rate is $48 per square foot among local listings currently available for lease.

For our detailed analysis of the latest rent and sale prices in South San Francisco, as well as overall market quality and new construction data, see South San Francisco Office Market Trends.

Office Spaces Classes

The office space market in South San Francisco incorporates a mix of properties of various ages, ratings, construction grades, and other quality indicators. 78.63% of total office listings in this city are in properties rated Class A. Class B accounts for 20.46% of traditional work spaces listed on the leasing market. Class C makes up 0.92% of such listings in South San Francisco. This data is current as of 2026.

South San Francisco Office Market Breakdown by Building Class
Class	Total Square Feet	Share of Total Office
A	14.3M	78.63%
B	3.7M	20.46%
C	167.2K	0.92%

Data was provided by Yardi Research Data, refers to properties larger than 50,000 square feet.

Top Neighborhoods for Office Space

Location is everything when it comes to office spaces. Tenants place great value on well positioned properties in amenity-rich areas, potentially boosting office attendance.

In South San Francisco, the greatest concentration of lease opportunities is in The East Side, Gateway and Oyster Point.

Office Classes in South San Francisco, California Neighborhoods

Gateway

Oyster Point

The East Side

Class A+/A
Class B
Class C

The Gateway neighborhood contains the most Class A office space, attracting premium tenants and corporate headquarters. Meanwhile, the neighborhood with the most Class B space is The East Side, offering quality space at affordable rates.

South San Francisco, CA in the news

South San Francisco Life Sciences Campus Gets Expansion Approval

Healthpeak Properties gets green light for Vantage Phase I and Vantage Phase II at massive South San Francisco life sciences campus.

South San Francisco, CA Office Spaces for Rent

Discovery Station - Building 2

Gateway of Pacific IV

101 Linden Ave

Discovery Station - Building 3

458 Carlton Ct

OFFICE SPACE FOR LEASE

400 Oyster Point Blvd, Suite 335

Infinite

425 Eccles Ave