O'Fallon, MO Office Spaces for Rent

Find the best O'Fallon, MO office space among 10 for rent listings currently on the market.

Waterbury Falls

856 Waterbury Falls Dr, O'Fallon, MO
Property Type

Office
For Lease

$22.50/SF/YR
3 spaces available / 3,000 - 13,000 SF
View Details (opens in new window)
80 Twenty Studios
80 Twenty Studios
2528 State Highway K, O'Fallon, MO
Property Type

Private Offices
For Lease

From $570/month
View Details (opens in new window)
1630 Market Center Blvd

1630 Market Center Blvd, O'Fallon, MO
Property Type

Office
For Lease

$22.00/SF/YR
1 space available / 9,033 SF
View Details (opens in new window)
1001 Boardwalk Springs Place
LifeWorks
1001 Boardwalk Springs Place #111, O'Fallon, MO
Property Type

Private Offices
For Lease

Contact for pricing
View Details (opens in new window)
1000-1021 Rondale Ct

1000-1021 Rondale Ct, Dardenne Prairie, MO
Property Type

Office
For Lease

$20.00/SF/YR
1 space available / 4,450 SF
View Details (opens in new window)
Lakeside Shoppes

4002 Winghaven Blvd, Winghaven Country Club, O'Fallon, MO
Property Type

Retail
For Lease Contact for pricing

1 space available / 2,454 SF
View Details (opens in new window)
216 Sonderen St O'Fallon

216 Sonderen St O'Fallon, O'Fallon, MO
Property Type

Office
For Lease

$1,800.00/YR
1 space available / 2,400 SF
View Details (opens in new window)
364 Veterans Memorial Pkwy

364 Veterans Memorial Pkwy, O Fallon, MO
Property Type

Office
For Lease

$21.00/SF/YR
1 space available / 2,400 SF
View Details (opens in new window)
Peruque Crossing

1061 Peruque Crossing Court, O'Fallon, MO
Property Type

Office
For Lease

$3.84 - $22.80/SF/YR
2 spaces available / 2,185 - 2,700 SF
View Details (opens in new window)
6700 Keaton Corporate Parkway

6700 Keaton Corporate Parkway, O'Fallon, MO
Property Type

Office
For Lease

$17.00/SF/YR
1 space available / 2,275 SF
View Details (opens in new window)
Single-Tenant, Class A Office Building For Lease in O’Fallon

5555 Winghaven Blvd, Winghaven Country Club, O'Fallon, MO
Property Type

Office
For Lease Contact for pricing

1 space available / 73,840 SF
View Details (opens in new window)

Frequently Asked Questions

Asking prices vary based on the property location, rating, amenities such as proximity to restaurants, cafes, and entertainment venues, as well as convenience of access to public transport, airports, and thoroughfares.

The minimum rental rate for office space in O'Fallon is $17 per square foot. Among listings of office space currently available for lease in O'Fallon, the maximum rental rate is $22.8 per square foot.
Most experts recommend an average of between 75 and 150 square feet of office space per person. However, it is important to keep in mind that how much office space you ultimately need depends on your activity and how you need to use the space, as much as it does on how many people it should accommodate. If you already know what size office would best suit your needs, use the available space size filter at the top of the search page to focus your search on the best fit for you.

You’ll find a home for almost any size of business in O'Fallon, as the local office market offers a wide range of options. Office spaces currently on the market go up to as much as 73,840 square feet in size for an individual listing.
However, there is a variety of differently sized opportunities below that maximum. For your consideration, the median size of an office space for lease in O'Fallon is 3,000 square feet, and the average office space size here is 11,639 square feet.
You can find 10 office listing(s) for lease in O'Fallon, which add up to a total of 118,783 square feet. Availability on the market includes a variety of office use types, such as General Office, Medical Office.

The most common office use type currently available for lease in O'Fallon is General Office, which is offered in 5 or 50.00% of listings. The second-most frequent office use type listed here is Medical Office, which account for 2 or 20.00% of office space currently available.
Sublease opportunities on the market include General Office, Medical Office.
The best choice of neighborhood for your office space will greatly depend on the elements that are most relevant to your business and your employees. However, a good criterion to start with is to look at the areas of the city that have the highest concentration of office properties, as these areas are generally well connected to transit options and have a good degree of amenity availability.
Each individual’s commuting experience will of course be different depending on a number of factors. Check the location description details for the office listings that catch your eye, to get an overview of walkability, access to public transport, the quality of infrastructure dedicated to biking commuters, as well as the proximity to parking facilities, fuel stations, and other essential amenities.
The O'Fallon office market incorporates a mix of properties of various ages, ratings, construction grades, and other quality indicators. Roughly 40% of total office space listings in the city are in properties rated Class A. Class B office space accounts for 10% of spaces listed on the leasing market. Class C office space makes up 20% of office space available in O'Fallon.

Buildings completed in and since the year 2000 account for 100% of office properties in the city and incorporate a total of 90,869 square feet.
There are, of course, a lot of things to factor in when you are looking for office space. Aspects including the accessibility of the location, the quality of the facility, the size of the space, the convenience of nearby amenities, the type and duration of the lease, and of course the cost are all part of the search and decision process. For a quick checklist of what you should take into account when researching the market, consider these seven tips for choosing the best office location for your business. Alternatively, for a comprehensive take on everything to consider when looking for office space, see our in-depth guide to finding office space for small or growing companies. The guide also includes insights from seasoned professionals and can serve as a helpful resource for growing companies, no matter their current size.
Are you looking to lease office space in the vicinity of your current location or in a particular neighborhood of O'Fallon? Using the interactive map, you can easily navigate to your preferred location and customize your search area around a specific point of interest. Select “Radius” from the Search Mode options menu, click on the map to set your search reference point, and expand the radius to select your desired search area. Browse available listings to find the best office space that meets your location, as well as other business needs.

O'Fallon, MO Office Inventory Breakdown

There are a number of factors that make a city attractive for businesses to relocate or expand, as well as for investors to enhance their portfolios through local acquisitions. Among the most important factors to consider are the size and quality of the local office market, which is an essential component of the local economy.

Total Office Space in O'Fallon: 1,450,336 Sq. Ft.

In 2025 the O'Fallon office market encompassed 1,450,336 square feet of space. Out of that total, 502,176 square feet were in office properties sized between 500,000 and 1,000,000 square feet. Meanwhile, 589,615 square feet were in office buildings sized between 50,000 and 100,000 square feet.
Class A office space makes up a 70.27% share of O'Fallon office inventory, while Class B office assets represent roughly 23.24% of the market total.

O'Fallon Office Market Breakdown by Building Size
Building Size Range	Total Square Feet	Share of Total Office
50k to 100k Sq. Ft.	589,615 Sq. Ft.	40.65%
100k to 500k Sq. Ft.	123,540 Sq. Ft.	8.52%
500k to 1M Sq. Ft.	502,176 Sq. Ft.	34.62%

O'Fallon Office Market Breakdown by Building Quality Rating
Class	Total Square Feet	Share of Total Office
Class A	1,019,172 Sq. Ft.	70.27%
Class B	337,008 Sq. Ft.	23.24%
Class C	27,374 Sq. Ft.	1.89%

Data was provided by CommercialEdge, refers to properties larger than 50,000 square feet.

About us

CommercialCafe is your go-to commercial real estate listing source. We partner with highly respected major brokerages from across the country to ensure high-quality listings that are updated frequently. Our online marketplace lists all commercial property types from office, coworking, retail, and industrial to special purpose properties.

CommercialCafe is a trusted Yardi brand and is an integral part of the CommercialEdge network — the fastest-growing network of online real estate marketplaces, which ranks on the 1st page of Google for all top markets, attracts more than 2 million monthly visits, and generates more than 350,000 broker contacts.

O'Fallon, MO Office Spaces for Rent

Waterbury Falls

80 Twenty Studios

1630 Market Center Blvd

1001 Boardwalk Springs Place

1000-1021 Rondale Ct

Lakeside Shoppes

216 Sonderen St O'Fallon

364 Veterans Memorial Pkwy

Peruque Crossing

6700 Keaton Corporate Parkway

Single-Tenant, Class A Office Building For Lease in O’Fallon

Frequently Asked Questions

O'Fallon, MO Office Inventory Breakdown

Total Office Space in O'Fallon: 1,450,336 Sq. Ft.

Other Popular Searches

Popular Coworking Searches

Popular Commercial Searches

About us

About Us

Our Tools