Des Peres, MO Office Spaces for Rent

Find the best Des Peres, MO office space among 15 for rent listings currently on the market.

13075 Manchester Road

13075 Manchester Road, Des Peres, St. Louis, MO
Property

Office

132,736 SF
Availability

1 Space

5,630 SF
Year Built

1986
For Lease

$32.50/SF/YR
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1101 Des Peres Road

1101 Des Peres Road, Des Peres, St. Louis, MO
Property

Office

144,773 SF
Availability

2 Spaces

10,235 SF
Year Built

1996
For Lease Contact for pricing
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Des Peres Medical Pavilion

2325 Dougherty Ferry Rd, Des Peres, St. Louis, MO
Property

Office

50,156 SF
Availability Contact for availability
Year Built

2001
For Lease Contact for pricing
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1010 - 1090 Old Des Peres Road

1010 1090 Old Des Peres Road, Des Peres, MO
Property

Office

62,485 SF
Availability

2 Spaces

2,561 SF
Year Built

1979
For Lease Contact for pricing
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Topping Office Center

13100 Manchester Road, Des Peres, St. Louis, MO
Property

Office

26,547 SF
Availability

1 Space

2,173 SF
Year Built

1974
For Lease

$19.00/SF/YR
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Des Peres Place

1000 Des Peres Road, Des Peres, St. Louis, MO
Property

Office

75,000 SF
Availability

1 Space

13,515 SF
Year Built

1980
For Lease

$26.00/SF/YR
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Des Peres Shopping Center

12085 Manchester Road, Des Peres, MO
Property

Retail

56,319 SF
Availability

16 Spaces

5,414 SF
Year Built

1963
For Lease Contact for pricing
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1110 Westmark Drive

1110 Westmark Drive, Des Peres, St. Louis, MO
Property

Office

5,000 SF
Availability

1 Space

5,000 SF
For Lease

$27.50/SF/YR
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Des Peres Corners

12332 Manchester Road, Des Peres, MO
Property

Retail

120,673 SF
Availability

3 Spaces

8,468 SF
For Lease Contact for pricing
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BMO Bank Building

13205 Manchester Rd Des Peres MO 63131, Des Peres, MO
Property

Office

7,736 SF
Availability

1 Space

7,825 SF
For Lease

$23.50/SF/YR
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Frequently Asked Questions

Asking prices vary based on the property location, rating, amenities such as proximity to restaurants, cafes, and entertainment venues, as well as convenience of access to public transport, airports, and thoroughfares.

The minimum rental rate for office space in Des Peres is $23.5 per square foot. Among listings of office space currently available for lease in Des Peres, the maximum rental rate is $27.5 per square foot.
Most experts recommend an average of between 75 and 150 square feet of office space per person. However, it is important to keep in mind that how much office space you ultimately need depends on your activity and how you need to use the space, as much as it does on how many people it should accommodate. If you already know what size office would best suit your needs, use the available space size filter at the top of the search page to focus your search on the best fit for you.

You’ll find a home for almost any size of business in Des Peres, as the local office market offers a wide range of options. Office spaces currently on the market go up to as much as 13,515 square feet in size for an individual listing.
You can find 15 office listing(s) for lease in Des Peres, which add up to a total of 46,939 square feet. Availability on the market includes a variety of office use types, such as General Office, Medical Office.

The most common office use type currently available for lease in Des Peres is General Office, which is offered in 4 or 26.67% of listings. The second-most frequent office use type listed here is Medical Office, which account for 3 or 20.00% of office space currently available.
Sublease opportunities on the market include General Office, Medical Office.
The best choice of neighborhood for your office space will greatly depend on the elements that are most relevant to your business and your employees. However, a good criterion to start with is to look at the areas of the city that have the highest concentration of office properties, as these areas are generally well connected to transit options and have a good degree of amenity availability.
Each individual’s commuting experience will of course be different depending on a number of factors. Check the location description details for the office listings that catch your eye, to get an overview of walkability, access to public transport, the quality of infrastructure dedicated to biking commuters, as well as the proximity to parking facilities, fuel stations, and other essential amenities.
The Des Peres office market incorporates a mix of properties of various ages, ratings, construction grades, and other quality indicators. Class B office space accounts for 33.33% of spaces listed on the leasing market.

Buildings completed in and since the year 2000 account for 10% of office properties in the city and incorporate a total of 50,156 square feet.
There are, of course, a lot of things to factor in when you are looking for office space. Aspects including the accessibility of the location, the quality of the facility, the size of the space, the convenience of nearby amenities, the type and duration of the lease, and of course the cost are all part of the search and decision process. For a quick checklist of what you should take into account when researching the market, consider these seven tips for choosing the best office location for your business. Alternatively, for a comprehensive take on everything to consider when looking for office space, see our in-depth guide to finding office space for small or growing companies. The guide also includes insights from seasoned professionals and can serve as a helpful resource for growing companies, no matter their current size.
Are you looking to lease office space in the vicinity of your current location or in a particular neighborhood of Des Peres? Using the interactive map, you can easily navigate to your preferred location and customize your search area around a specific point of interest. Select “Radius” from the Search Mode options menu, click on the map to set your search reference point, and expand the radius to select your desired search area. Browse available listings to find the best office space that meets your location, as well as other business needs.

Des Peres, MO Office Inventory Breakdown

There are a number of factors that make a city attractive for businesses to relocate or expand, as well as for investors to enhance their portfolios through local acquisitions. Among the most important factors to consider are the size and quality of the local office market, which is an essential component of the local economy.

Total Office Space in Des Peres: 1,408,151 Sq. Ft.

In 2025 the Des Peres office market encompassed 1,408,151 square feet of space. Out of that total, 548,921 square feet were in office properties sized between 500,000 and 1,000,000 square feet. Meanwhile, 365,686 square feet were in office buildings sized between 50,000 and 100,000 square feet.
Class A office space makes up a 38.98% share of Des Peres office inventory, while Class B office assets represent roughly 58.99% of the market total.

Des Peres Office Market Breakdown by Building Size
Building Size Range	Total Square Feet	Share of Total Office
50k to 100k Sq. Ft.	365,686 Sq. Ft.	25.97%
100k to 500k Sq. Ft.	277,509 Sq. Ft.	19.71%
500k to 1M Sq. Ft.	548,921 Sq. Ft.	38.98%

Des Peres Office Market Breakdown by Building Quality Rating
Class	Total Square Feet	Share of Total Office
Class A	548,921 Sq. Ft.	38.98%
Class B	830,609 Sq. Ft.	58.99%
Class C	28,621 Sq. Ft.	2.03%

Data was provided by CommercialEdge, refers to properties larger than 50,000 square feet.

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Des Peres, MO Office Spaces for Rent

13075 Manchester Road

1101 Des Peres Road

Des Peres Medical Pavilion

1010 - 1090 Old Des Peres Road

Topping Office Center

Des Peres Place

Des Peres Shopping Center

1110 Westmark Drive

Des Peres Corners

BMO Bank Building

Frequently Asked Questions

Des Peres, MO Office Inventory Breakdown

Total Office Space in Des Peres: 1,408,151 Sq. Ft.

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