45 South Street

45 South Street, Hopkinton, MA 01748

Property Information

  • For Lease Contact for pricing
  • Property Type Industrial - Flex - Industrial
  • Property Size 66,024 SF
  • Year Built 1984
  • Date Updated Oct 26, 2026
  • Dock High Doors 8
  • HVAC None

Description

45 South Street sits just a few hundred yards off Interstate 495 at the Exit 54A on-ramp (formerly Exit 21) — one exit south of the I-495 / I-90 Mass Pike junction, making it very convenient for commuters. Join nearly companies including EMC Corporation, Caliper Life Sciences, Lonza, Liberty Mutual & more.NAI Parsons Commercial Group Boston is pleased to announce the availability of flex space at 45 South Street in Hopkinton, MA — from ±4,719 SF of first floor flex with 16′ clear up to 29,644 SF of built-out office, lab and warehouse.

Highlights

  • First Floor Flex Space: ±4,719 SF, 50% office / 50% warehouse, 16 clear, 1 loading dock. Ideal for flex, R&D, and light assembly.
  • Lab/Flex Space: ±9,534 29,644 SF with 28 private offices, back of house lab/warehouse, up to 16' clear, and 6 tailboard loading docks.
  • Sits just a few hundred yards off Interstate 495 at the Exit 54A on-ramp (formerly Exit 21) one exit south of the I-495 / I-90 Mass Pike junction.

2 Spaces Available

45 South St

Space Type

Flex - Industrial

Lease Rate

Contact for pricing

Total Space

4,719 SF

Floor

First Floor

Divisible Space

4,719 - 4,719 SF

Available Date

Immediate

Renewal Option

Yes

Sublease

No

50% office / 50% warehouse with 1 loading dock.

45 South St

Space Type

Flex - Industrial

Lease Rate

Contact for pricing

Total Space

29,644 SF

Divisible Space

9,534 - 29,644 SF

Available Date

Immediate

Renewal Option

Yes

Sublease

No

±9,534 – 29,644 SF lab/flex space with 6 tailboard loading docks, 28 private offices, and up to 16' ceilings.

Contacts

Location

Located at 45 South Street, Hopkinton, MA 01748, this property is part of the Hopkinton neighborhood and Boston market.

Contact Listing Broker
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