Florida Keys, FL Commercial Real Estate for Lease and Sale
Explore 79 listing(s) of commercial real estate in Florida Keys, FL to find the best space for your business.
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74560 Overseas Hwy, Port Antigua, ISLAMORADA, FLProperty Type- Other
For Sale- $3,150,000
Built in 1983 / Property size 6,071 SF -
1215 Duval St, Upper Duval, Key West, FLProperty Type- Other
For Sale- $3,475,000
Built in 1953 / Property size 2,244 SF -
218 Whitehead St, Truman Annex, Key West, FLProperty Type- Retail
For Sale- $4,400,000
Built in 1942 / Property size 7,755 SF -
532 Margaret Street, Old Town Key West, Key West, FLProperty Type- Other
For Sale- $2,500,000
Built in 1958 / Property size 2,490 SF -

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97340 Overseas Highway, Mandalay, Key Largo, FLProperty Type- Unassigned
For Sale- $12,900,000
Built in 1994 / Property size 20,084 SF -
88701 Overseas Hwy, Plantation Beach, Tavernier, FLProperty Type- Other
For Sale- $2,400,000
Built in 1999 / Property size 1,957 SF -
27340 Overseas Highway, Ramrod Key, Cudjoe Key, FLProperty Type- Other
For Sale- $12,250,000
Built in 1958 / Property size 10,956 SF -
521 United St, Upper Duval, Key West, FLProperty Type- Other
For Sale- $20,350,000
Built in 1938 / Property size 12,183 SF -
22814 Overseas Hwy, Cudjoe Key, Cudjoe, FLProperty Type- Other
For Sale- $875,000
Built in 1976 / Property size 1,120 SF -
10095 Overseas Highway, Farara Shores, Marathon, FLSpace Type- Office
For Lease- $22.44 - $29.00/SF/YR
2 spaces available / 1,000 - 2,010 SF -
10035 Overseas Highway, Farara Shores, Marathon, FLSpace Type- Office
For Lease- $22.39 - $28.80/SF/YR
2 spaces available / 1,000 - 4,020 SF -
81900 Overseas Hwy, Stratton's, Islamorada, FLProperty Type- Retail
For Sale- $2,950,000
Built in 1975 / Property size 5,232 SF -
5701 Overseas Hwy, Sombrero Beach, MARATHON, FLProperty Type- Other
For Sale- $395,000
Built in 1979 / Property size 1,128 SF -
Boat Rental Business, Beachside, Key West, FLProperty Type- Other
For Sale- $150,000
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5701 Overseas Hwy, Sombrero Beach, MARATHON, FLProperty Type- Other
For Sale- $265,000
Built in 1979 / Property size 947 SF -
1421 First Street, New Town Key West, Key West, FLProperty Type- Office
For Sale- $1,250,000
Property size 1,393 SF -
221 Duval St, Historic Seaport, Key West, FLSpace Type- Retail
For Lease- $10,500.00/MO
1 space available / 635 SF -
421 - 423 Simonton Street, Historic Seaport, Key West, FLProperty Type- Other
For Sale- $5,850,000
Built in 2020 / Property size 3,010 SF -
30330 Overseas Hwy, Big Pine Key, Big Pine, FLProperty Type- Other
For Sale- $3,100,000
Built in 1979 / Property size 5,250 SF -
7070 Overseas Hwy, Roosevelt Point, MARATHON, FLProperty Type- Other
For Sale- $1,400,000
Built in 1954 / Property size 4,168 SF -
68200 Overseas Hwy, Layton, LAYTON, FLProperty Type- Other
For Sale- $415,000
Built in 1978 / Property size 800 SF -
951 Caroline St, Historic Seaport, Key West, FLSpace Type- Office
For Lease- $3,600.00/MO
1 space available / 1,200 SF -
518 Duval St, Downtown Key West, Key West, FLSpace Type- Office
For Lease- $15,500.00/SF/YR
1 space available / 2,155 SF -
1111 12th Street, New Town Key West, Key West, FLSpace Type- Office
For Lease- $4,635.00 - $26,276.25/MO
3 spaces available / 1,235 - 7,007 SF -
3140 Northside Dr # F, New Town Key West, Key West, FLProperty Type- Office
For Sale- $1,200,000
Built in 1991 / Property size 2,045 SF -
400 Duval Street , Historic Seaport, Key West, FLSpace Type- Retail
For Lease- $18,052.00/MO
1 space available / 1,733 SF -
607 Fleming St, Historic Seaport, Key West, FLSpace Type- Retail
For Lease- $4,550.00 - $4,650.00/MO
2 spaces available / 805 - 1,496 SF -
802 White Street, Old Town Key West, Key West, FLSpace Type- Office
For Lease- $3,250.00/MO
1 space available / 994 SF -
701 Simonton St, Old Town Key West, Key West, FLProperty Type- Other
For Sale- $1,850,000
Built in 1938 / Property size 1,745 SF -
90311 Old Hwy, Tropical Atlantic Shores, Tavernier, FLProperty Type- Other
For Sale- $6,800,000
Built in 1981 / Property size 14,400 SF -
323 Overseas Hwy, Big Coppitt Key, Key West, FLProperty Type- Other
For Sale- $3,600,000
Built in 2020 / Property size 6,912 SF -
6150 2nd St, Stock Island, Key West, FLSpace Type- Retail
For Lease- $4,500.00/MO
1 space available / 2,118 SF -
200 Treasure Harbor Drive, Treasure Harbor, Islamorada, FLProperty Type- Other
For Sale- $6,995,000
Built in 1948 / Property size 1,069 SF -
314 Simonton St, Historic Seaport, Key West, FLProperty Type- Multi-Family
For Sale- $4,950,000
Built in 1921 / Property size 8,472 SF -
718-720 Caroline Street, Historic Seaport, Key West, FLProperty Type- Retail
For Sale- $1,995,000
Built in 1918 / Property size 3,424 SF -
100 Duval Street, Historic Seaport, Key West, FLSpace Type- Retail
For Lease- $41,000.00/MO
1 space available / 5,500 SF -
210-216 Duval Street, Historic Seaport, Key West, FLSpace Type- Retail
For Lease- $16,500.00 - $48,683.00/MO
2 spaces available / 2,000 - 5,901 SF -
408 Greene St, Historic Seaport, Key West, FLSpace Type- Retail
For Lease- $7,500.00/MO
1 space available / 1,398 SF -
38 Coco Plum Drive, Coco Plum, Marathon, FLProperty Type- Unassigned
For Sale- $4,950,000
Built in 1994 / Property size 5,439 SF -
30200 Overseas Highway, Big Pine Key, FLProperty Type- Unassigned
For Sale- $999,000
Built in 1970 / Property size 3,200 SF -
425 Eaton St, Historic Seaport, Key West, FLSpace Type- Office
For Lease- $2,250.00/MO
1 space available / 385 SF -
218 Whitehead St, Truman Annex, Key West, FLSpace Type- Mixed Use
For Lease- $2,750.00 - $5,250.00/MO
3 spaces available / 501 - 1,407 SF -
524 Eaton Street, Historic Seaport, Key West, FLSpace Type- Office
For Lease- $700.00 - $1,600.00/MO
5 spaces available / 70 - 320 SF -
99202 Overseas Highway, Sunset Cove, Key Largo, FLProperty Type- Other
For Sale- $15,000,000
Built in 1953 / Property size 23,092 SF -
11400 Overseas Hwy, Key Colony, MARATHON, FLProperty Type- Other
For Sale- $489,000
Built in 1973 / Property size 1,350 SF -
818 Elizabeth St, Old Town Key West, Key West, FLProperty Type- Multi-Family
For Sale- $4,549,000
Built in 1944 / Property size 5,317 SF -
88101 Overseas Highway, Plantation Beach, Islamorada, FLSpace Type- Office
For Lease- $5.56 - $7.00/SF/MO
3 spaces available / 100 - 125 SF -
626 Josephine Parker Dr, Downtown Key West, Key West, FLSpace Type- Office
For Lease- $950.00 - $2,200.00/MO
2 spaces available / 330 - 340 SF -
1213 Truman Ave, The Meadows, Key West, FLSpace Type- Office
For Lease- $3,900.00/MO
1 space available / 1,020 SF -
5300 Overseas Highway, Stock Island, FLSpace Type- Retail
For Lease- $5,000.00/MO
1 space available / 789 SF -
81901 Overseas Highway, Stratton's, Islamorada, FLProperty Type- Unassigned
For Sale- $2,699,000
Property size 4,943 SF -
431 Front Street, Historic Seaport, Key West, FLSpace Type- Retail
For Lease- $5,300.00 - $5,828.00/MO
2 spaces available / 326 - 657 SF -
701 Simonton St, Old Town Key West, KEY WEST, FLProperty Type- Other
For Sale- $1,850,000
Built in 1938 / Property size 1,745 SF