Florida Keys, FL Commercial Real Estate for Lease and Sale
Explore 82 listing(s) of commercial real estate in Florida Keys, FL to find the best space for your business.
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10035 Overseas Highway, Farara Shores, Marathon, FLSpace Type- Office
For Lease- $22.39 - $28.80/SF/YR
2 spaces available / 1,000 - 4,020 SF -
9141 Overseas Highway, Gulfstream Shore, Marathon, FLSpace Type- Office
For Lease- $850.00/MO
1 space available / 83 SF -
68200 Overseas Hwy, Layton, LAYTON, FLProperty Type- Other
For Sale- $415,000
Built in 1978 / Property size 800 SF -
11400 Overseas Hwy, Key Colony, MARATHON, FLProperty Type- Other
For Sale- $489,000
Built in 1973 / Property size 1,350 SF -

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5670 Laurel Avenue, Stock Island, Key West, FLProperty Type- Other
For Sale- $1,950,000
Property size 5,258 SF -
88701 Overseas Hwy, Plantation Beach, Tavernier, FLProperty Type- Other
For Sale- $2,400,000
Built in 1999 / Property size 1,957 SF -
701 Simonton St, Old Town Key West, Key West, FLProperty Type- Other
For Sale- $1,850,000
Built in 1938 / Property size 1,745 SF -
532 Margaret Street, Old Town Key West, Key West, FLProperty Type- Other
For Sale- $2,950,000
Built in 1958 / Property size 2,490 SF -
421 - 423 Simonton Street, Historic Seaport, Key West, FLProperty Type- Other
For Sale- $5,850,000
Built in 2020 / Property size 3,010 SF -
3140 Northside Dr # F, New Town Key West, Key West, FLProperty Type- Office
For Sale- $1,200,000
Built in 1991 / Property size 2,045 SF -
626 Josephine Parker Dr, Downtown Key West, Key West, FLSpace Type- Office
For Lease- $950.00 - $2,200.00/MO
2 spaces available / 330 - 340 SF -
Boat Rental Business, Beachside, Key West, FLProperty Type- Other
For Sale- $150,000
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62250 Overseas Hwy # 11, Duck Key, Conch Key, FLProperty Type- VacantLand
For Sale- $5,750,000
Built in 1997 / Property size 2,478 SF -
524 Eaton Street, Historic Seaport, Key West, FLSpace Type- Office
For Lease- $700.00 - $1,500.00/MO
3 spaces available / 70 - 320 SF -
419 Duval St, Historic Seaport, Key West, FLSpace Type- Retail
For Lease- $8,900.00/MO
1 space available / 900 SF -
5580 1st Avenue, Stock Island, Key West, FLProperty Type- Industrial
For Sale- $2,200,000
Built in 1964 / Property size 2,040 SF -
221 Duval St, Historic Seaport, Key West, FLSpace Type- Retail
For Lease- $12,000.00/MO
1 space available / 500 SF -
1301 SW 2nd Ave, Mandalay, Key Largo, FL -
103400 Overseas Hwy, Cross Key Waterway Estates, Key Largo, FL -
3706 North Roosevelt Boulevard #208, Key West, FLSpace Type- Private Offices
For Lease-
From $950/month
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91200 Overseas Hwy, Camp Pleasant, Tavernier, FL -
99603-99625, Port Largo, Key Largo, FL -
6011 Peninsular Ave, Stock Island, Key West, FL -
101499 Overseas Hwy, Hibiscus Park, Key Largo, FL -
1 Kyle Way S, Knights Key Village, Marathon, FLProperty Type- Multi-Family
For Sale- $1,450,000
Built in 2026 / Property size 44,100 SF -
6495 Overseas Hwy, Puerta Del Sol, Marathon, FLSpace Type- Land
For Lease- $175,000.00/YR
1 space available / 44,866.8 SF -
89015 Overseas Hwy, Indian Waterways, Islamorada, FLProperty Type- Industrial
For Sale- $149,000
Property size 1,948 SF -
86701 Overseas Hwy, Treasure Harbor, Islamorada, FLSpace Type- Retail
For Lease- $2.00 - $2.50/SF/YR
1 space available / 1,000 SF -
103400 Overseas Highway 1st & 2nd Floor, Key Largo, FL