Otay Mesa, San Diego, CA Office Spaces for Rent

Find the best Otay Mesa, San Diego, CA office space among 16 for rent listings currently on the market.

Empire Centre - 7880 & 7920 Airway Road

7880 Airway Road, Otay Mesa, San Diego, CA
Property

Industrial

132,661 SF
Availability

2 Spaces

6,094 SF
Year Built

1999
For Lease

$2.50/SF/YR
View Details (opens in new window)
THINK Campus at Millenia Chula Vista - Building 1

SEC Millenia Avenue & Stylus Street, Otay Ranch, Chula Vista, CA
Property

Office

168,000 SF
Availability

4 Spaces

150,000 SF
Year Built

2025
For Lease Contact for pricing
View Details (opens in new window)
THINK Campus at Millenia Chula Vista - Building 2

1785 Millenia Avenue, Otay Ranch, Chula Vista, CA
Property

Office

168,000 SF
Availability

5 Spaces

168,000 SF
Year Built

2025
For Lease Contact for pricing
View Details (opens in new window)
Avalyn

1774 Metro Avenue, Otay Ranch, Chula Vista, CA
Property

Retail

16,000 SF
Availability

5 Spaces

7,559 SF
For Lease Contact for pricing
View Details (opens in new window)
1750 E Palomar St

1750 E Palomar St, Otay Ranch, Chula Vista, CA
Property

Retail

3,495 SF
Availability

1 Space

1,573 SF
Year Built

2005
For Lease Contact for pricing
View Details (opens in new window)

Otay Mesa, San Diego, CA Office Inventory Breakdown

There are a number of factors that make a city attractive for businesses to relocate or expand, as well as for investors to enhance their portfolios through local acquisitions. Among the most important factors to consider are the size and quality of the local office market, which is an essential component of the local economy.

Total Office Space in San Diego: 226,266 Sq. Ft.

In 2025 the San Diego office market encompassed 226,266 square feet of space.

San Diego Office Market Breakdown by Building Size
Building Size Range	Total Square Feet	Share of Total Office
50k to 100k Sq. Ft.	52,881 Sq. Ft.	23.37%
100k to 500k Sq. Ft.	107,000 Sq. Ft.	47.29%

San Diego Office Market Breakdown by Building Quality Rating
Class	Total Square Feet	Share of Total Office
Class B	119,266 Sq. Ft.	52.71%
Class C	107,000 Sq. Ft.	47.29%

Data was provided by CommercialEdge, refers to properties larger than 50,000 square feet.

About us

CommercialCafe is your go-to commercial real estate listing source. We partner with highly respected major brokerages from across the country to ensure high-quality listings that are updated frequently. Our online marketplace lists all commercial property types from office, coworking, retail, and industrial to special purpose properties.

CommercialCafe is a trusted Yardi brand and is an integral part of the CommercialEdge network — the fastest-growing network of online real estate marketplaces, which ranks on the 1st page of Google for all top markets, attracts more than 2 million monthly visits, and generates more than 350,000 broker contacts.

Otay Mesa, San Diego, CA Office Spaces for Rent

Empire Centre - 7880 & 7920 Airway Road

THINK Campus at Millenia Chula Vista - Building 1

THINK Campus at Millenia Chula Vista - Building 2

Avalyn

1750 E Palomar St

Otay Mesa, San Diego, CA Office Inventory Breakdown

Total Office Space in San Diego: 226,266 Sq. Ft.

Other Popular Searches

Popular Coworking Searches

Popular Commercial Searches

About us

About Us

Our Tools