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Office Space for Rent in San Diego, CA - 808 Listings

San Diego, CA - Office Space for Lease

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San Diego, CA Office Overview

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Among sunny San Diego’s most prosperous commercial real estate scenes are the Central City, Central Coast, Downtown Business District and South Bay submarkets. With a metropolitan population of over 3.3 million people, the economy is dynamic and robust, and the San Diego commercial real estate market continues to expand around a vibrant mix of business and industry.

As of mid-2017, the Greater San Diego office market encompasses nearly 61 million square feet of existing office space in properties larger than 50,000 square feet. Due to the city's unique geographic location between Southern California and Mexico, the market continues to see strong demand.

San Diego, CA Office Inventory Description

The city's Pacific Coast location and proximity to Mexico plays a major role in the culture of the business community and office property development. Nearly 60% of the office space in San Diego is Class A, while Class B office properties make up another 39% of San Diego's office inventory.

Located along the I-8 and Friars Road, the Mission Valley East office scene is one of San Diego’s densest markets and home to Pacific Center I & II, and the Centerside 3111 & 3131 office properties. Businesses such as General Dynamics and First American Title Insurance Company are located in Mission Valley.

Other growing San Diego office submarkets include the Kearny Mesa area, Rancho Bernardo commercial real estate along the I-15 South, and the Scripps Ranch area, which is home to trophy office buildings such as the Scripps Corporate Plaza.

San Diego, CA Commercial Inventory Breakdown

Office Spaces

Total: 81,451,840 SF

Data provided by Yardi Matrix, properties over 50k SF, includes office with retail

By square footage range:

  • 50k to 100k SF: 22,164,889 SF / 27.21% of total office
  • 100k to 500k SF: 53,138,718 SF / 65.24% of total office
  • 500k to 1M SF: 6,148,233 SF / 7.55% of total office

By class:

  • Class A+: 1,502,699 SF / 1.84% of total office
  • Class A: 41,444,327 SF / 50.88% of total office
  • Class B: 32,259,551 SF / 39.61% of total office
  • Class C: 521,353 SF / 0.64% of total office

Top 10 Largest Office Buildings

in San Diego

Office building Address Sqft Year built
Manchester Pacific Gateway - Building 1B - Manchester Pacific Gateway Tower SEC West Broadway Street & North Harbor Drive, 92132 804,122 2020
Makers Quarter - Block C NEC F Street & 14th Street, 92101 796,000 n/a
One America Plaza 600 West Broadway, 92101 623,000 1991
Rancho Vista Corporate Center - Hewlett-Packard Campus 16399 West Bernardo Drive, 92127 622,211 1970
Makers Quarter - Block A 1500 Broadway, 92101 591,300 n/a
701 B Street 701 B Street, 92101 560,329 1982
1 Columbia Place 401 West A Street, 92101 556,943 1983
Summit Rancho Bernardo - 16550 West Bernardo Drive 16550 West Bernardo Drive, 92127 542,328 2016
Symphony Towers 750 B Street, 92101 530,000 1990
9800 & 9855 Summers Ridge Road 9800 Summers Ridge Road, 92121 522,000 n/a

Most Recently-Built Office Buildings

in San Diego

Office building Address Sqft Year built
i3 4775 Executive Drive, 92121 316,000 2017
Illumina Worldwide Headquarters - Buildings 6 5200 Ilumina Way, 92122 295,609 2017
Rancho Bernardo Medical Center 16899 West Bernardo Drive, 92127 100,000 2017
Eastgate Terrace 9779 Towne Centre Drive, 92121 96,435 2017
Torrey Point 3420 Carmel Valley Road, 92121 89,940 2017
ARE Spectrum - 3013 Science Park Road 3013 Science Park Road, 92121 63,000 2017
Summit Rancho Bernardo - 16550 West Bernardo Drive 16550 West Bernardo Drive, 92127 542,328 2016
Alexandria Center for Life Science at Campus Pointe - 10290 Campus Point Drive 10290 Campus Point Drive, 92121 304,326 2016
Eastgate Summit 4850 Eastgate Mall, 92121 65,000 2016
Otonomy Headquarters 4796 Executive Drive, 92121 61,755 2016

San Diego, CA Green Office Space


Of the Top 30 Green Office Markets in the U.S., San Diego ranks 19th for energy efficient office buildings. While just over 3% of the office buildings larger than 50,000 square feet are LEED Certified, over 6% rank as Energy Star Certified and over 8% are recognized as green buildings.

As both tenants and investors seek out green certified assets to complete their portfolios, the green office trend continues to accelerate. According to the most recent report from the San Diego U.S. Green Building Council, there are nearly 600 LEED-certified Projects with a total of more than 59 million square feet of space in the San Diego metropolitan area.

The 2017 National Green Building Adoption Index looked at commercial office properties in 30 major U.S. markets and found that, including EPA Energy Star-labeled buildings, the percentage of green certification has increased, from just under 5% in 2005 to 38% as of mid-2017. San Diego has most recently placed 19th on this survey.

San Diego, CA's Top Office-Using Sectors

Major users of San Diego office space include the defense & military, tourism, international trade and technology & manufacturing industries. This diverse mix of business combined with a growing number of small businesses and start-up companies continue to attract both national and global office investors, contributing to the San Diego area's nearly $220 billion in annual gross metropolitan product.

  • Defense & Military – San Diego is home to a deep-water seaport that includes the only major submarine and shipbuilding yard on the West Coast. Defense contractors such as General Atomics, Cubic, and NASSCO are headquartered here and contribute to the demand for Class A office space in San Diego.
  • Tourism – With over 34 million annual visitors spending $1 billion tourism plays a major role in the San Diego economy and job market, with Marriott International and Club Med North America located in the city.
  • International Trade – With its commercial seaport and prime location relative to Mexico international trade companies play a significant role in the demand for San Diego office space, such as Mitchell International and UTC Aerospace Systems.
  • Technology – San Diego is home to technology companies such as Qualcomm, Nokia, LG Electronics, and Kyocera International.

San Diego Demographics


  • Total Population1,359,791
  • Male Population(50.2 %) 682,040
  • Female Population(49.8 %) 677,751
  • Median Age34.00


  • Average Household Income$90,052
  • Median Household Income$66,116
  • Median Income Under 25$31,263
  • Median Income 25-44$71,144
  • Median Income 45-64$78,569
  • Median Income Over 65$49,185


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