San Ysidro, CA Commercial Real Estate for Lease and Sale

Explore 12 listing(s) of commercial real estate in San Ysidro, CA to find the best space for your business.

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San Ysidro Village

4330 Camino De La Plaza, San Ysidro, CA
Space Type

Retail
For Lease Contact for pricing

8 spaces available / 1,117 - 89,300 SF
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Executive Offices

524 Calle Primera, Suite 1005-1006, San Ysidro, CA
Space Type

Private Offices
For Lease

From $1,400/month
Space for up to 2 people
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309 Sycamore Road

309 Sycamore Rd, San Ysidro, CA
Property Type

Other
For Sale Contact for pricing

Built in 1955 / Property size 2 SF
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424 West San Ysidro Boulevard

424 West San Ysidro Boulevard, San Ysidro, San Diego, CA
Space Type

Retail
For Lease Contact for pricing

1 space available / 3,000 SF
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628 E San Ysidro Blvd

628 E San Ysidro Blvd, San Ysidro, CA
Space Type

Retail
For Lease Contact for pricing

5 spaces available / 1,000 - 7,530 SF
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307 Sycamore Road

307 Sycamore Rd, San Ysidro, CA
Property Type

Other
For Sale

$9,250,000
Built in 2016 / Property size 18 SF
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674 E San Ysidro Blvd

674 E San Ysidro Blvd, San Ysidro, CA
Space Type

Retail
For Lease Contact for pricing

1 space available / 3,919 SF
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2345 Via Segundo

2345 Via Segundo, San Ysidro, San Diego, CA
Property Type

Industrial
For Sale

$2,650,000
Built in 1984 / Property size 10,410 SF
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Border Business Center

464 West Calle Primera, San Ysidro, CA
Space Type

Industrial
For Lease Contact for pricing

3 spaces available / 960 - 1,200 SF
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4575 Camino De La Plaza

4575 Camino De La Plaza, San Ysidro, San Diego, CA
Space Type

Retail
For Lease Contact for pricing

5 spaces available / 1,075 - 1,556 SF
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674B E San Ysidro Blvd

674B E SAN YSIDRO BLVD, San Ysidro, San Diego, CA
Space Type

Retail
For Lease Contact for pricing

1 space available / 3,919 SF
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502 E San Ysidro Blvd

502 E San Ysidro Blvd, San Ysidro, San Diego, CA
Space Type

Retail
For Lease Contact for pricing

1 space available / 1,690 SF
View Details

Frequently Asked Questions

CommercialCafe’s CRE offering in San Ysidro is enabled by a network of 4 active brokers from 3 different firms, ensuring a wide variety of listings. Working with an experienced professional can make a real difference. Learn more about the benefits of working with a broker.

To get in touch with a broker, use the "Contact Property" button on this search page or fill in the contact form provided on each individual property’s listing page.
The profitability of a commercial real estate investment depends on a multitude of factors working together. These factors include the quality of the asset itself, local market conditions, the state of the local economy and the demand for that particular type of commercial property, to name a few.

San Ysidro, CA Commercial Space Listings

Commercial Space for Lease - Breakdown

The 8 listings for commercial real estate currently available for rent in San Ysidro add up to 157,280 square feet across various property types. Here's a breakdown of the available space by category:

Property Type	Count of Listings	Total Sq. Ft.
Retail	7	154,160
Industrial	1	3,120

Retail Space:

There are 7 retail listings available, adding up to a total of 154,160 square feet.
Retail spaces account for approximately 87% of the local commercial market, while the average share taken up by retail in all U.S. markets is 57%.

Industrial Space:

The industrial market in San Ysidro offers 1 listing, amounting to 3,120 available square feet.
Industrial spaces, including warehouses and manufacturing sites, make up about 12% of the total commercial space available in the market, compared to a nationwide average of 42%.

The data presented in this section was last updated as of October 14, 2026

Commercial Space for Sale - Breakdown

There is currently 1 property listed for sale in the San Ysidro market, adding up to 10,410 square feet of space available for purchase. Here is a breakdown of the commercial space for sale listed locally:

1 industrial property

The data presented in this section was last updated as of October 14, 2026

Property Type	Count of Listings	Total Sq. Ft.
Industrial	1	10,410

San Ysidro, CA Commercial Real Estate for Lease and Sale

San Ysidro Village

Executive Offices

309 Sycamore Road

424 West San Ysidro Boulevard

628 E San Ysidro Blvd

307 Sycamore Road

674 E San Ysidro Blvd

2345 Via Segundo

Border Business Center

4575 Camino De La Plaza

674B E San Ysidro Blvd

502 E San Ysidro Blvd

Frequently Asked Questions

San Ysidro, CA Commercial Space Listings

Commercial Space for Lease - Breakdown

Commercial Space for Sale - Breakdown

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