Cambridge, MA Commercial Real Estate for Lease and Sale

Explore 167 listing(s) of commercial real estate in Cambridge, MA to find the best space for your business.

CRE Market FAQs

501 Massachusetts Avenue

501 Massachusetts Avenue, Cambridge, MA
Space Type

Private Offices
For Lease

Contact for pricing
Space for 1 to 6 people
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CambridgeSide - 100 Cambridgeside Place

100 Cambridgeside Place, East Cambridge, Cambridge, MA
Space Type

Office
For Lease Contact for pricing

1 space available / 165,000 SF
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59-63 Church Street

59 Church Street, West Cambridge, Cambridge, MA
Space Type

Office
For Lease Contact for pricing

4 spaces available / 777 - 2,021 SF
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128 & 137 Sidney Street

128 Sidney Street, Cambridgeport, Cambridge, MA
Space Type

Office
For Lease Contact for pricing

1 space available / 37,700 SF
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750 Main Street

750 Main Street, Cambridge, MA
Space Type

Private Offices
For Lease

Contact for pricing
Space for 10 to 75 people
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44 R Brattle Street

44 R Brattle Street, West Cambridge, Cambridge, MA
Space Type

Office
For Lease Contact for pricing

2 spaces available / 887 - 1,414 SF
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20 Brattle Street

20 Brattle Street, Riverside, Cambridge, MA
Space Type

Office
For Lease Contact for pricing

2 spaces available / 3,349 - 11,665 SF
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Eliot Square

104 Mount Auburn St, West Cambridge, Cambridge, MA
Space Type

Office
For Lease Contact for pricing

3 spaces available / 389 - 1,926 SF
View Details

Frequently Asked Questions

Here is a rundown of the primary commercial real estate property types currently available in Cambridge:
- Office Space: The market includes 8,643,252 square feet of office spaces in addition to 206 coworking locations.
- Retail Space: Between malls, restaurants and stores, Cambridge is home to 1,099,457 square feet of available retail space.
- Industrial Space: Warehouses, distribution centers, manufacturing facilities and other industrial types total 224,189 square feet of available space in Cambridge.
The average rent for commercial real estate in Cambridge is $43.73 per square foot. However, specific rates may vary widely by property type, class and quality. The cheapest commercial space in Cambridge costs $19.95, while the city’s premium locations ask up to $70.59.
Here is a breakdown of the average size of different property classes (also known as asset class or property type):
- Class A/A+ properties have an average size of 207,834 square feet.
- Class B properties are sized 66,305 square feet, on average.
- Class C properties span an average of 36,996 square feet.
The best area for commercial real estate in Cambridge will depend greatly on your needs. The neighborhood with the largest overall number of commercial listings is East Cambridge, home to no fewer than 65 listings for space of all types. If you're looking for office space, Cambridgeport has the highest concentration of office listings at 54.

Meanwhile, Cambridgeport has the highest number of industrial availabilities (3), while West Cambridge boasts the largest number of retail listings in the city (20).
CommercialCafe’s CRE offering in Cambridge is enabled by a network of 71 active brokers from 33 different firms, ensuring a wide variety of listings. Working with an experienced professional can make a real difference. Learn more about the benefits of working with a broker.

To get in touch with a broker, use the "Contact Property" button on this search page or fill in the contact form provided on each individual property’s listing page.
The profitability of a commercial real estate investment depends on a multitude of factors working together. These factors include the quality of the asset itself, local market conditions, the state of the local economy and the demand for that particular type of commercial property, to name a few.

Asking rents in the city can be as high as $70.59 per square foot. In particular, the property type commanding the highest lease rates in Cambridge is Office space.
The average size of a commercial property here stands at 39,174. However, different asset classes and zoning laws will result in vastly different property sizes. Here is a breakdown of the average size of different commercial asset classes in Cambridge:
Office properties:
- Average size: 109,409 square feet.
- Largest property: 1 Floor (155,823 square feet).
Retail properties:
- Average size: 28,192 square feet.
- Largest property: 625 Massachusetts Ave (28,880 square feet).
Industrial properties:
- Average size: 44,838 square feet.
- Largest property: 1st Floor (50,537 square feet).

Cambridge, MA Commercial Space Listings

Commercial Space for Lease - Breakdown

The 135 listings for commercial real estate currently available for rent in Cambridge add up to 3,010,224 square feet across various property types. Here's a breakdown of the available space by category:

Property Type	Count of Listings	Total Sq. Ft.
Office	84	2,582,553
Retail	44	243,462
Industrial	4	145,035
Other	3	39,174

Office properties:

The market has 84 active office listings, encompassing 2,582,553 square feet.
Cambridge office spaces currently listed on CommercialCafe represent 62% of the total commercial real estate market in Cambridge, compared to an average of 39% across all markets tracked by CommercialCafe.

Retail Space:

There are 44 retail listings available, adding up to a total of 243,462 square feet.
Retail spaces account for approximately 32% of the local commercial market, while the average share taken up by retail in all U.S. markets is 34%.

Industrial Space:

The industrial market in Cambridge offers 4 listings, amounting to 145,035 available square feet.
Industrial spaces, including warehouses and manufacturing sites, make up about 2% of the total commercial space available in the market, compared to a nationwide average of 25%.

The data presented in this section was last updated as of September 10, 2026

Commercial Space for Sale - Breakdown

There are currently 4 properties listed for sale in the Cambridge market, adding up to 18,719 square feet of space available for purchase. Here is a breakdown of the commercial space for sale listed locally:

1 office property
2 retail properties
1 industrial property

The data presented in this section was last updated as of September 10, 2026

Property Type	Count of Listings	Total Sq. Ft.
Office	1	4,332
Retail	2	7,745
Industrial	1	6,642

Cambridge, MA Commercial Real Estate Market Overview

Cambridge has a robust and diverse economy fueled by a host of major medical, biotech, and pharmaceutical companies, as well as its high concentration of successful startups originating in Kendall Square.

Home to both Harvard and MIT, the city boasts an impressive talent pool. As a result, companies such as Pfizer, Sanofi and Novartis — as well as nonprofit groups and think tanks, such as the Lincoln Institute of Land Policy, the National Bureau of Economic Research and the Smithsonian Astrophysical Observatory — drive the demand for commercial real estate properties in Cambridge.

Public transit in Cambridge is handled by the Massachusetts Bay Transportation Authority (MBTA), which operates an underground rapid transit system, buses and commuter rail networks, as well as water shuttles. The city also is serviced by the Charles River Transportation Management Agency (CRTMA). U.S. Route 1 and I-93, Route 2, Route 16 and the McGrath Highway (Route 28) also provide access into Cambridge.

Cambridge Commercial Real Estate Overview

Cambridge, MA Commercial Real Estate for Lease and Sale

501 Massachusetts Avenue

CambridgeSide - 100 Cambridgeside Place

59-63 Church Street

128 & 137 Sidney Street

750 Main Street

44 R Brattle Street

20 Brattle Street

Eliot Square

Frequently Asked Questions

Cambridge, MA Commercial Space Listings

Commercial Space for Lease - Breakdown

Commercial Space for Sale - Breakdown

Cambridge, MA Commercial Real Estate Market Overview

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